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Apoptosis in Vero cells infected with Akabane, Aino and Chuzan virus

Lim SI, Kweon CH, Yang DK, Tark DS, Kweon JH

  • KMID: 1091209
  • J Vet Sci.
  • 2005 Sep;6(3):251-254.
Akabane, Aino and Chuzan virus are arthropod-borne (arbo)viruses mainly associated with reproductive failures in cattle. We investigated apoptosis in Vero cells (C-1586) infected with Akabane, Aino and Chuzan virus. The...
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Mechanisms of Apoptosis on Human Lens Epithelium after Ultraviolet Light Exposure

Kim ST, Koh JW

PURPOSE: The purpose of this study is to understand the mechanism of apoptosis occurring on a cultured human lens epithelial cell line after exposure to ultraviolet (UV) light. We intended...
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Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis

Chung HS, Park SR, Choi EK, Park HJ, Griffin RJ, Song CW, Park H

  • KMID: 1094699
  • Exp Mol Med.
  • 2003 Jun;35(3):181-188.
The role of sphingomyelinase (SMase) activation and mitogen activated protein kinases (MAPKs) activation in cellular apoptosis was investigated during the hyperthermic treatment of HL-60 human leukemia cells. Treating the cells...
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Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis

Wang Z, Bhattacharya N, Weaver M, Petersen K, Meyer M, Gapter L, Magnuson N

  • KMID: 1119212
  • J Vet Sci.
  • 2001 Dec;2(3):167-179.
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice,...
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Ultrastructural observation of human neutrophils during apoptotic cell death triggered by Entamoeba histolytica

Sim S, Kim KA, Yong TS, Park SJ, Im KI, Shin MH

Neutrophils are important effector cells against protozoan extracellular parasite Entamoeba histolytica, which causes amoebic colitis and liver abscess in human beings. Apoptotic cell death of neutrophils is an important event...
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Sensitivity of CD95-induced apoptosis in different proliferative status of human retinal pigment epithelial cells

Chang JH, Kang SW, Ham DI

It is known that CD95 (APO-1/Fas) is expressed on the cell surface, and apoptotic cell death can be induced by the CD95 ligation in the cultured, proliferating human retinal pigment...
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Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells

Lee WJ, Yoo HS, Suh PG, Lim JS, Oh S, Lee YM

  • KMID: 1123763
  • Exp Mol Med.
  • 2004 Oct;36(5):420-427.
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 micrometer of FTY720, sphingosine accumulated in...
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Toxoplasma gondi Inhibits Apoptosis in Infected Cells by Caspase Inactivation and NF-kappaB Activation

Kim JY, Ahn MH, Jun HS, Jung JW, Ryu JS, Min DY

Our experiments aimed to clarify the mechanism by which host cell apoptosis is inhibited by infection with the intracellular protozoan parasite, Toxoplasma gondii (T. gondii). Mouse spleen cells were cultured...
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Phagocytosis induces superoxide formation and apoptosis in macrophages

Park JB

  • KMID: 1093604
  • Exp Mol Med.
  • 2003 Oct;35(5):325-335.
Phagocytosis by inflammatory cells is an essential step and a part of innate immunity for protection against foreign pathogens, microorganism or dead cells. Phagocytosis, endocytotic events sequel to binding particle...
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Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes

Farooq M, Kim YH, Im SU, Chung EJ, Hwang SY, Sohn MY, Kim MK, Kim JC

  • KMID: 938882
  • Exp Mol Med.
  • 2001 Sep;33(3):169-173.
Apoptosis is regulated by interaction of antiapoptotic Bcl-2 family proteins with various proapoptotic proteins, several of which are also members of the Bcl-2 family. BNIP3 (formerly NIP3) is a proapoptotic...
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Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro

Zhang XH, Wu H, Tang S, Li QN, Xu J, Zhang M, Su YN, Yin B, Zhao QL, Kemper N, Hartung J, Bao ED

To determine heat-shock protein (Hsp)90 expression is connected with cellular apoptotic response to heat stress and its mechanism, chicken (Gallus gallus) primary myocardial cells were treated with the Hsp90 promoter,...
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Norcantharidin Induces Human Melanoma A375-S2 Cell Apoptosis through Mitochondrial and Caspase Pathways

An WW, Wang MW, Tashiro SI, Onodera S, Ikejima T

Norcantharidin (NCTD) is the demethylated form of cantharidin, which is the active substance of mylabris. To examine the pathway of NCTD-induced A375-S2 cell death, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide (MTT) assay,...
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The Role of Barrier Dysfunction and Change of Claudin Expression in Inflammatory Bowel Disease

Kim TI

No abstract available.
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Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system

Fukaya Y, Kuroda M, Aoyagi Y, Asada S, Kubota Y, Okamoto Y, Nakayama T, Saito Y, Satoh K, Bujo H

  • KMID: 1383794
  • Exp Mol Med.
  • 2012 May;44(5):330-339.
Auto-transplantation of adipose tissue is commonly used for the treatment of tissue defects in plastic surgery. The survival of the transplanted adipose tissue is not always constant, and one of...
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Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells

Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS

  • KMID: 1090961
  • Exp Mol Med.
  • 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as...
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Human Papilloma Virus Type 16 E7 Genes Protect Astrocytes against Apoptotic and Necrotic Death Induced by Hydrogen Peroxide

Lee WT, Lee JE, Lee SH, Jang HS, Giffard RG, Park KA

Hydrogen peroxide is considered to be a dose- and time-dependent mediator in apoptotic and necrotic death. In this study, we examined the signaling of the E6 and E7 proteins with...
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Cytochrome C-dependent Fas-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2

Kim BE, Roh SR, Kim JW, Jeong SW, Kim IK

  • KMID: 1109319
  • Exp Mol Med.
  • 2003 Aug;35(4):293-300.
Cyclopentenone prostaglandins (PGs) have antiproliferative activity on various tumor cell growth in vitro. Particularly, 9-deoxy-(9,12)-13,14-dihydro PGD2( delta12-PGJ2) was reported for its antineoplastic and apoptotic effects on various cancer cells, but...
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p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells

Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters

  • KMID: 1457532
  • Exp Mol Med.
  • 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1...
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Expression of CD40 and Apoptosis Related Molecules in Autoimmune Thyroid Diseases

Kie JH, Cho MS, Yang WI

Apoptosis is responsible for the loss of thyrocytes in autoimmune thyroiditis. Recent investigations into the pathogenesis of apoptosis have revealed that the important roles of suicide molecules expression on both...
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Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis

Yuan B, Zhou S, Lu Y, Liu J, Jin X, Wan H, Wang F

BACKGROUND/AIMS: This animal study aimed to define the underlying cellular mechanisms of intestinal barrier dysfunction. METHODS: Rats were fed 4% with dextran sodium sulfate (DSS) to induce experimental colitis. We analyzed...
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