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Chronological effects of atherogenic diets on the aorta, liver and spleen of rabbits

Song SH, Min BI, Lee JH, Cho KS

To investigate the temporal progression of atherogenesis on the aorta and involvement of the monocyte-macrophage system in the liver and spleen, we fed 74 rabbits with high fat (14 or...
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Spontaneous Disruption of Mycotic Aneurysm Involving Innominate Artery

Oh S, Yoon YW, Jang GJ, Ahn JB, Hong GP, Gang GH, Gang MS, Hong YU, Gee JH

We report a case of ruptured mycotic aneurysm involving innominate artery requiring an urgent surgical treatment. A 62-yr-old woman presented with fever and dyspnea. Previously, she was diagnosed with colon...
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Weissella confusa Bacteremia in an Immune-Competent Patient with Underlying Intramural Hematomas of the Aorta

Lee W, Cho SM, Kim M, Ko YG, Yong D, Lee K

No abstract available.
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Development of an Animal Experimental Model for a Bileaflet Mechanical Heart Valve Prosthesis

Choo SJ, Kim KI, Park NH, Song JM, Choi IC, Shim JY, Lee SK, Kwon YJ, Kim CN, Lee JW

The objective of this study was to develop a pre-clinical large animal model for the in vivo hemodynamic testing of prosthetic valves in the aortic position without the need for...
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Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways

Lim JH, Um HJ, Park JW, Lee IK, Kwon TK

Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this...
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Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants

Kim DK, Huh JE, Lee SH, Hong KP, Park JE, Seo JD, Lee WR

It has been proposed that the local renin-angiotensin system is activated in the adventitia after vascular injury. However, the physiological role of Angiotensin II (Ang II) in the adventitia has...
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Genistein Supplementation Inhibits Atherosclerosis with Stabilization of the Lesions in Hypercholesterolemic Rabbits

Lee CS, Kwon SJ, Na SY, Lim SP, Lee JH

The effect of genistein on aortic atherosclerosis was studied by immunohistochemistry with RAM-11 and HHF-35 antibodies and western blotting for matrix metalloproteinase-3 (MMP-3) in New Zealand White rabbits. After provocation...
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KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model

Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT

  • KMID: 1402317
  • Exp Mol Med.
  • 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive...
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Visceral Fat Thickness Predicts Fatty Liver in Koreans with Type 2 Diabetes Mellitus

Kim HJ, Cho MH, Park JS, Nam JS, Kang ES, Ahn CW, Cha BS, Lee EJ, Lim SK, Kim KR, Lee HC, Huh KB

Our aim was to study whether visceral adiposity is a predictor of diabetic fatty liver in Korean type 2 diabetes mellitus. In this study, abdominal ultrasonography was used to assess...
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The Beneficial Effect of Renin-Angiotensin-Aldosterone System Blockade in Marfan Syndrome Patients after Aortic Root Replacement

Lee SJ, Oh J, Ko YG, Lee S, Chang BC, Lee DY, Kwak YR, Choi D

PURPOSE: In this study, we evaluated the long term beneficial effect of Renin-Angiotensin-Aldosterone System (RAAS) blockade therapy in treatment of Marfan aortopathy. MATERIALS AND METHODS: We reviewed Marfan syndrome (MFS) patients...
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