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Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

Lee SJ, Oh ST, Park GM, Kim TS, Ryu JS, Choi HK

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to...
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