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Drug Resistance and in Vitro Susceptibility of Plasmodium falciparum in Thailand during 1988-2003

Suwandittakul N, Chaijaroenkul W, Harnyuttanakorn P, Mungthin M, Na Bangchang K

The aim of the present study was to investigate antimalarial drug pressure resulting from the clinical use of different antimalarials in Thailand. The phenotypic diversity of the susceptibility profiles of...
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Plasmodium vivax Drug Resistance Genes; Pvmdr1 and Pvcrt-o Polymorphisms in Relation to Chloroquine Sensitivity from a Malaria Endemic Area of Thailand

Rungsihirunrat K, Muhamad P, Chaijaroenkul W, Kuesap J, Na-Bangchang K

The aim of the study was to explore the possible molecular markers of chloroquine resistance in Plasmodium vivax isolates in Thailand. A total of 30 P. vivax isolates were collected...
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Effect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparum

Ha YR, Hwang BG, Hong Y, Yang HW, Lee SJ

The parasite Plasmodium falciparum causes severe malaria and is the most dangerous to humans. However, it exhibits resistance to their drugs. Farnesyltransferase has been identified in pathogenic protozoa of the...
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Prevalence of Drug Resistance-Associated Gene Mutations in Plasmodium vivax in Central China

Lu F, Wang B, Cao J, Sattabongkot J, Zhou H, Zhu G, Kim K, Gao Q, Han ET

  • KMID: 1792136
  • Korean J Parasitol.
  • 2012 Dec;50(4):379-384.
Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fight against malaria, and molecular markers for the drug resistance have been applied as an adjunct in...
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Plasmodium vivax dhfr Mutations among Isolates from Malarious Areas of Iran

Zaman J, Shahbazi A, Asgharzadeh M

The use of sulfadoxine and pyrimethamine (SP) for treatment of vivax malaria is uncommon in most malarious areas, but Plasmodium vivax isolates are exposed to SP because of mixed infections...
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Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China

Wang SQ, Wang GZ, Li YC, Meng F, Lin SG, Zhu ZH, Sun DW, He CH, Hu XM, Du JW

Pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. However, pyronaridine is rarely used in Hainan Island clinically, and artesunate is not widely used as a...
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Gametocyte Clearance in Uncomplicated and Severe Plasmodium falciparum Malaria after Artesunate-Mefloquine Treatment in Thailand

Tangpukdee N, Krudsood S, Srivilairit S, Phophak N, Chonsawat , Yanpanich , Kano S, Wilairatana P

Artemisinin-based combination therapy (ACT) is currently promoted as a strategy for treating both uncomplicated and severe falciparum malaria, targeting asexual blood-stage Plasmodium falciparum parasites. However, the effect of ACT on...
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