- Changes in Thyrotropin Receptor Blocking Antibody after Antithyroid drug Administration to Patients with Atrophic Autoimmune Thyroiditis (Primary Myxedema)
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Kim SY, Cho BY, Lee HK, Chung JH, Koh CS, Shin CS, Kim WB
- KMID: 2461568
- J Korean Soc Endocrinol.
- 1994 Sep;10(3):229-241.
It is well Known that antithyroid drug treatment of Graves' disease suppresses excessive thyroid hormone synthesis and causes a parallel decrease in serum thyroid autoantibody levels including thyroid stimulating antibodies(TSAb)... -
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- Blocking of Histamine Release and IgE Binding to FcepsilonRI on Human Basophils by Antibodies Produced in Camels
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Khaled AQ, Sana Y, Abdulrahman R, Raida K, Sami AH
- KMID: 2130265
- Allergy Asthma Immunol Res.
- 2015 Nov;7(6):583-589.
- doi: 10.4168/aair.2015.7.6.583
PURPOSE: The production of camel heavy-chain antihuman IgE (huIgE) that has the potential to block IgE-FcepsilonRI interaction and histamine release by basophils. METHODS: Camels were immunized with a synthetic loop peptide... -
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- Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion
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Kim MY, Cho JY
- KMID: 2350508
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):515-523.
- doi: 10.4196/kjpp.2016.20.5.515
Adhesion events of monocytes represent an important step in inflammatory responses induced by chemokines. The β1-integrin CD29 is a major adhesion molecule regulating leukocyte migration and extravasation. Although several adhesion... -
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- Graves' Disease: Can It Be Cured?
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Wiersinga
- KMID: 2441676
- Endocrinol Metab.
- 2019 Mar;34(1):29-38.
- doi: 10.3803/EnM.2019.34.1.29
Whether or not Graves' hyperthyroidism can be really cured, depends on the definition of “cure.†If eradication of thyroid hormone excess suffices for the label “cure,†then all patients can... -
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- Recent Updates in Cancer Immunotherapy
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Chung MK, Kim BY
- KMID: 1964244
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2015 Jul;58(7):449-455.
- doi: 10.3342/kjorl-hns.2015.58.7.449
Immune system is believed to play an important role in cancer initiation as well as its progression, as evidenced by many studies revealing suppressed, defective anti-tumor immunity in cancer patients.... -
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- A Case of Transient Neonatal Hypothyroidism Due to Maternal TSH-Binding Inhibitor Immunoglobulins
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Kim SS, Song MY, Shu BK, Lee BC
- KMID: 2193919
- J Korean Soc Pediatr Endocrinol.
- 1998 May;3(1):84-89.
Recognition of transient forms of neonatal hypothyroidism is very important to prevent the complications of congenital hypothyroidism. Transplacental passage of TSH-binding inhibitory immunoglobulins(TBII) may result in transient congenital hypothyroidism. Transient... -
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- Immunologic Mechanism of Experimental and Therapeutic Ultraviolet B Responses
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Lew W
- KMID: 1571484
- Immune Netw.
- 2002 Jun;2(2):65-71.
- doi: 10.4110/in.2002.2.2.65
The immunological mechanism of the responses to ultraviolet (UV) B radiation in mouse models were investigated by the suppression of contact hypersensitivity (CHS) and delayed type hypersensitivity (DTH), and susceptibility... -
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- Thrombospondin-1 and Inhibition of Tumor Growth
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Jeong GB
- KMID: 2150435
- Korean J Phys Anthropol.
- 2015 Dec;28(4):175-184.
- doi: 10.11637/kjpa.2015.28.4.175
Thrmobospondin-1 is the multifunctional protein that modulates endothelial cell and tumor cell behavior via several cell surface receptors and inhibits angiogenesis. In vitro, thrombospondin-1 alters adhesion, proliferation, motility, and survival... -
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- Enhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy
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Shin JH, Park HB, Choi K
- KMID: 2168054
- Immune Netw.
- 2016 Apr;16(2):134-139.
- doi: 10.4110/in.2016.16.2.134
Programmed death-1 (PD-1) is a strong negative regulator of T lymphocytes in tumor-microenvironment. By engaging PD-1 ligand (PD-L1) on tumor cells, PD-1 on T cell surface inhibits anti-tumor reactivity of... -
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- Simultaneous Inhibition of CXCR4 and VLA-4 Exhibits Combinatorial Effect in Overcoming Stroma-Mediated Chemotherapy Resistance in Mantle Cell Lymphoma Cells
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Kim YR, Eom KS
- KMID: 2150820
- Immune Netw.
- 2014 Dec;14(6):296-306.
- doi: 10.4110/in.2014.14.6.296
There is growing evidence that crosstalk between mantle cell lymphoma (MCL) cells and stromal microenvironments, such as bone marrow and secondary lymphoid tissues, promotes tumor progression by enhancing survival and... -
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- Effect of TrkA and p75NTR on the Survival of Neurons in the Cultured Organotypic Hippocampal Slice
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Yang DW, Kwon OJ, Kim YI, Kim BS
- KMID: 1636112
- J Korean Neurol Assoc.
- 2006 Dec;24(6):564-570.
BACKGROUND: Nerve growth factor (NGF) promotes the survival and differentiation of vertebrate neurons, and their actions are mediated by two classes of cell surface receptors: tyrosine kinase A receptor (TrkA)... -
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- Blocking Interleukin-4 Receptor α Using Polyethylene Glycol Functionalized Superparamagnetic Iron Oxide Nanocarriers to Inhibit Breast Cancer Cell Proliferation
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Shaik AP, Shaik AS, Majwal AA, Faraj AA
- KMID: 2378104
- Cancer Res Treat.
- 2017 Apr;49(2):322-329.
- doi: 10.4143/crt.2016.091
PURPOSE: The specific targeting of interleukin-4 receptor α (IL4Rα) receptor offers a promising therapeutic approach for inhibition of tumor cell progression in breast cancer patients. In the current study, the... -
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- A Case of Management for Advanced Hepatocellular Carcinoma with Extrahepatic Metastasis by Autologous Natural Killer Cells Combined with Immune Checkpoint Inhibitor
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Woo A, Kim EJ, Shin SY, Jeon HJ, Park H, Chon YE, Lee YB, Hwang SG, Rim KS, Lee JH
- KMID: 2409651
- J Liver Cancer.
- 2018 Mar;18(1):67-74.
- doi: 10.17998/jlc.18.1.67
Hepatocellular carcinoma (HCC) has extremely poor prognosis. Immunotherapy has emerged as a new treatment for a number of cancers. Adoptive immunotherapy is one of the important cancer immunotherapy, which relies... -
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- Regulatory Mechanism of p66 Shc Expression by TSH in FRTL-5 Cells
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Park YJ, Park ES, Kim TY, Lee YY, Lee SH, Park DJ, Shin CS, Park KS, Kim SY, Lee HK, Cho BY
- KMID: 2200130
- J Korean Soc Endocrinol.
- 2003 Feb;18(1):45-55.
BACKGROUND: Thyroid goiters are very common, however, the mechanism of development is not fully understood. A TSH receptor has been known to activate two different signaling pathways the cAMP/protein kinase... -
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- Effects of Ser47-Point Mutation on Conformation Structure and Allergenicity of the Allergen of Der p 2, a Major House Dust Mite Allergen
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Kulwanich , Thanyaratsrisakul S, Jirapongsananuruk O, Hales BJ, Thomas WR, Piboonpocanun S
- KMID: 2426791
- Allergy Asthma Immunol Res.
- 2019 Jan;11(1):129-142.
- doi: 10.4168/aair.2019.11.1.129
PURPOSE: Hypoallergenic recombinant Der p 2 has been produced by various genetic manipulations, but mutation of a naturally polymorphic amino acid residue known to affect IgE binding has not been... -
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- Heterogeneity of TSH Receptor Autoantibodies in Autoimmune Thyroid Disease
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Kim WB, Cho BY, Kim KA, Chung JH, Min YK, Lee MS, Lee MK, Kim KW
- KMID: 2331059
- J Korean Soc Endocrinol.
- 1997 Jun;12(2):176-193.
BACKGROUND: It has been known that most of thyroid stimulating antibodies (TSAbs) may interact with epitopes near N-terminal, and thyroid stimulation blocking antibodies (TSBAbs) near C-terminal on the extracellular domain... -
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- Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation
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Kim EY, Lee EN, Lee J, Park HJ, Chang CY, Jung DY, Choi SY, Lee SK, Joh JW, Kim SJ
- KMID: 1094154
- Exp Mol Med.
- 2006 Jun;38(3):284-294.
Blockade of signal 1 or 2 for T-cell activation by the use of anti-CD45RB and anti-CD154 monoclonal antibodies (mAb) (two-signal blockade) has been proven effective in preventing or delaying graft... -
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- Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-gamma
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Lee KJ, Kim HA, Kim PH, Lee HS, Ma KR, Park JH, Kim DJ, Hahn JH
- KMID: 1103320
- Exp Mol Med.
- 2004 Dec;36(6):534-544.
During chronic inflammatory response, mono- cytes/macrophages produce 92-kDa matrix metalloproteinase-9 (MMP-9), which may contribute to their extravasation, migration and tissue remodeling. Activation of peroxisome proliferator- activated factor receptor-gamma (PPAR-gamma) has... -
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- Beta ig-h3 promotes renal proximal tubular epithelial cell adhesion, migration and proliferation through the interaction with alpha3beta1 integrin
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Park SW, Bae JS, Kim KS, Park SH, Lee BH, Choi JY, Park JY, Ha SW, Kim YL, Kwon TH, Kim IS, Park RW
- KMID: 1097102
- Exp Mol Med.
- 2004 Jun;36(3):211-219.
Betaig-h3 (betaig-h3) is a secretory protein composed of fasciclin I-like repeats containing sequences that allows binding of integrins and glycosaminoglycans in vivo. Expression of betaig-h3 is responsive to TGF-beta and... -
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