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Molecular mechanisms of general anesthesia

Son Y

General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood....
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Actions of General Anesthetics against Ischemic Brain Injury

Min KT

No abstract available.
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Anesthesia and sodium channel

Kim HJ

  • KMID: 1482461
  • Hanyang Med Rev.
  • 2008 Nov;28(4):36-39.
Voltage-gated sodium channels are large glycoproteins that permit selective sodium ion conduction in excitable cells such as neurons. They generate upstroke of action potential and transmit depolarizing impulses through the...
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General anesthetics: neuroprotective or neurotoxic?

Min KT

  • KMID: 2046848
  • Anesth Pain Med.
  • 2013 Apr;8(2):75-81.
Many historical general anesthetics have been waxed and waned in the market of anesthetic field, mostly due to organ toxicities related to their metabolism, active metabolites and biodegradation, or other...
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Letter to the Editor: Is Propofol Good Choice for Procedural Sedation? Evaluation of Propofol in Comparison with Other General Anesthetics for Surgery in Children Younger than 3 Years

Kim SC

No abstract available.
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A Case of General Anesthesia for a Patient of Congenital` Esophageal Atresia with Tracheo-esophageal Fistula

Park DS, Choi HM, Kim BK

  • KMID: 2358168
  • Korean J Anesthesiol.
  • 1972 Jun;5(1):57-59.
The authors have experienced a case of general anesthesia for a patient of congenital esophageal atresia with tracheo-esophageal fistula. Paramount importance of particular attention to the maintenance of patent airway...
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Clinical Experience with Cardiac Arrest during General Anesthesia in the Reserpinized Patient

Song HS

  • KMID: 2357932
  • Korean J Anesthesiol.
  • 1976 Jun;9(1):57-61.
The author have experienced two cases of cardiac arrest during general anesthesia foroperation of total hysterectomy and cholecystectomy in the reserpinized patient. There are many influecning factors for cardiac depression...
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The Author's Response: Evaluation of Propofol in Comparison with Other General Anesthetics for Surgery in Children Younger than 3 Years: a Systematic Review and Meta-Analysis

Hong H, Hahn S, Choi Y, Jang MJ, Kim S, Lee JH, Kim HS

No abstract available.
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Changes in Serum Electrolytes Caused by General Anesthetics

Park JW

  • KMID: 2240878
  • Korean J Anesthesiol.
  • 1985 Mar;18(1):53-57.
The changes of the serum potaseum, chloride and CO2 concentration during ether, halothane, enflurane and balanced anesthesia were compared before anesthesia and during anesthesia 78 surgical patients. Anesthesia induced by...
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Volatile General Anesthetics and Tandem Pore Domain K+ Channel

Shin WJ

  • KMID: 1482465
  • Hanyang Med Rev.
  • 2008 Nov;28(4):63-72.
Two-pore domain K+ (K2P) channels are recently described. They have properties of background K+ channels, and play a crucial role in setting the resting membrane potential and regulating cell excitability....
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Changes in Serum Concentrations of Insulin-like Growth Factor-1 (IGF-1) during Different Methods of General Anesthesia

Kim JH, Baik HJ

BACKGROUND: IGFs (insulin-like growth factors) exert acute anabolic effects on protein and carbohydrate metabolism, and have a long-term impact on cell proliferation, differentiation, and apoptosis. The purpose of this study...
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Caudal Anesthesia for Pediatric Surgery & Postoperative Pain Control

Kim KH, Lee KH

The caudal epidural anesthesia has been popular due to the postoperative pain relief and the reduction of the amount of general anesthetics. It is also technically simple and safe both...
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The effect of lidocaine on apoptotic neurodegeneration in the developing mouse brain

Lee JH, Park YH, Song HG, Park HP, Kim HS, Kim CS, Kim JT

BACKGROUND: General anesthetics induce neuronal apoptosis in the immature brain. Regional anesthesia using local anesthetics can be an alternative to general anesthesia. Therefore, this study investigated the possible effect of...
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Changes in Serum Concentrations of Insulin-like Growth Factor Binding Protein-3 after General Anesthesia Using Propofol or Isoflurane

Woo JH, Kim JH, Baik HJ, Lee M, Kim YJ

OBJECTIVES: The insulin-like growth factor binding proteins (IGFBP) regulate the bioavailability and bioactivity of insulin-like growth factor. We aimed to evaluate whether the IGFBP-3 level undergo major changes during perioperative...
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The BIS Change and Neonatal Effect during General Anesthesia for a Cesarean Section

Kwon MS, Kim CH, Lee GY, Kim DY

BACKGROUND: The problem of psychological complications (trauma) by intraoperative awareness is a well discussed issue recently. The bispectral index (BIS) is reported to be closely related to the sedation and...
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Spinal Antinociceptive Mechanism of Isoflurane and Enflurane via the GABAA Receptor in Rats

Choi DK, Kim YK, Ham KD, Hwang JH

Background: Several studies have suggested that the spinal cord may be an important site of anesthetic action and have established that general anesthetics potentiate the effects of GABA at the...
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Addictive Effects of Pancuronium and General Anesthetics on an Isolated Rat Intestine Preparation

Park ST, Kim IS, Choi SJ

  • KMID: 1932785
  • Korean J Anesthesiol.
  • 1980 Mar;13(1):7-14.
The addictive effects by pancuronium on relaxation response to ether, methoxyflurane. halothane, trilene and enfluranc were investigated in the isolated rat intestine preparation. The following results were obtained. 1)...
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General Anesthetics and Single-Channel Recording

Kim KH, Shin WJ

  • KMID: 1482464
  • Hanyang Med Rev.
  • 2008 Nov;28(4):53-62.
Introduction of patch-clamp techniques allowed an increase in resolution of membrane current recordings. However, the technique was limited by apparent need for direct contact of pipette with cell membrane. Thus,...
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The use of intra-cellular signaling pathways in anesthesiology and pain medicine field

Joo JD

At the level of individual cells, signaling is crucial in cell division, differentiation, metabolic control and death. Reception of the signals depends on receptor proteins that are usually at the...
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Intravascular Migration of an Epidural Catheter Despite using Several Testing Maneuvers

Kim YT, Kim SS, Ryu JK, Jung W

Epidural anesthesia for cesarean section allows the mother to be awake, minimizes or completely avoids the problem of maternal aspiration and neonatal drug depression from general anesthetics. But epidural anesthesia...
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