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Gintonin facilitates catecholamine secretion from the perfused adrenal medulla

Na SY, Kim KH, Choi MS, Ha KS, Lim DY

The present study was designed to investigate the characteristics of gintonin, one of components isolated from Korean Ginseng on secretion of catecholamines (CA) from the isolated perfused model of rat...
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Antinociceptive Effects of Amiloride and Benzamil in Neuropathic Pain Model Rats

Jeong S, Lee SH, Kim YO, Yoon MH

Amiloride and benzamil showed antinocicepitve effects in several pain models through the inhibition of acid sensing ion channels (ASICs). However, their role in neuropathic pain has not been investigated. In...
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Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells

Bae YJ, Yoo JC, Park N, Kang D, Han J, Hwang E, Park JY, Hong SG

Cells can resist and even recover from stress induced by acute hypoxia, whereas chronic hypoxia often leads to irreversible damage and eventually death. Although little is known about the response(s)...
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Effect of Amiloride to Retinal Toxicity Induced by Tissue Plasminogen Activator

Kim US, Oh HS, Kwon OW, Chung I, Lee SH, Lee JH

PURPOSE: The effects of amiloride on cellular toxicity caused by tissue plasminogen activator (tPA) in mouse primary retinal cells were investigated. METHODS: Primary retinal cell cultures were maintained using glial conditioned...
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A Case of Lithium-Induced Nephrogenic Diabetes Insipidus and Rhabdomyolysis

Moh I, Lee YK, Son SY, Sin YH, Lee SM, Lee DH, Noh JW

  • KMID: 2264255
  • Korean J Med.
  • 2012 Mar;82(3):367-370.
A 59-year-old woman was admitted to our hospital with polydipsia and general weakness. She had a 30-year history of bipolar disorder and was being treated with risperidone (4 mg/day) and...
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Uridine-5'-Triphosphate Stimulates Chloride Secretion via Cystic Fibrosis Transmembrane Conductance Regulator and Ca2+-Activated Chloride Channels in Cultured Human Middle Ear Epithelial Cells

Son EJ, Gee HY, Lee MG, Lee WS, Choi JY

BACKGROUND AND OBJECTIVES: Nucleotide binding to purinergic P2Y receptors contributes to the regulation of fluid and ion transport in the middle ear epithelial cells. Here, we investigated the regulatory mechanism...
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Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines

Lee HJ, Rho J, Gui SR, Kim MK, Lee YK, Lee YS, Kim JE, Cho E, Cho M, Hwang TH

BACKGROUND/AIMS: JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma...
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Renal Expression of Ammonia Transporters in Rats with Amiloride-Induced Renal Tubular Acidosis

Kim SJ, Kim HY, Choi JH, Kim JT, Kim JE, Yeon MH, Kim SM, Kwon SK, Shin KS

  • KMID: 2259292
  • Korean J Med.
  • 2011 Jun;80(6):687-696.
BACKGROUND/AIMS: Renal tubular acidosis (RTA) decreases the net acid excretion, predominantly due to a decrease in urinary ammonia excretion. This study examined whether this decrement is associated with changes in...
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Modulators of Ion Transport in Nasal Polyps: An in situ Measurement of Short-Circuit Current

Lee JH, Rhee CS, Kim DW, Lee CH

OBJECTIVES: To examine possible modulators of the ion transport through the apical membrane of the nasal polyps. METHODS: The study was conducted using the freshly-excised nasal polyps from the patients...
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Role of Gap Junction in the Regulation of Renin Release and Intracellular Calcium in As 4.1 Cell Line

Han JH, Hong BZ, Kwak YG, Yuan K, Park WH, Kim SZ, Kim SH

  • KMID: 2285333
  • Korean J Physiol Pharmacol.
  • 2007 Jun;11(3):107-112.
Gap junction protein, connexin, is expressed in endothelial cells of vessels, glomerulus, and renin secreting cells of the kidney. The purpose of this study was to investigate the role of...
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Hypertensive Hypokalemic Disorders

Choi KB

Hypokalemia is a common clinical problem. The kidney is responsible for long term potassium homoeostasis, as well as the serum potassium concentration. The main nephron site where K secretion is...
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Proper Use of Diuretics

Choi KH

Diuretics are among the most commonly used drugs. They primarily block active reabsorption of sodium at different sites in the nephron, thereby increasing urinary losses of NaCl and H2O. This...
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A Case of Congenital Nephrogenic Diabetes Insipidus Confirmed by Gene Analysis

Cho EY, Oh JH, Koh DK

  • KMID: 1763549
  • Korean J Pediatr.
  • 2005 Jun;48(6):669-674.
Nephrogenic diabetes insipidus (NDI) is a disorder in which the secretion of antidiuretic hormone is normal, but the response of the renal collecting tubules to vasopressin is impaired. Compared with...
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A Case of Severe Prolonged Hypoglycemia Caused by Combined Ramipril and Amiloride Treatment in a Nondiabetic Woman

Cho MH, Kim DM, Kim CS, Park JS, Nam JY, Chang JH, Park J, Ahn CW, Cha BS, Lim SK, Kim KR, Lee HC

  • KMID: 2008184
  • J Korean Diabetes Assoc.
  • 2004 Dec;28(6):554-557.
The relationship between angiotensin converting enzyme inhibition and hypoglycemia remains controversial. An 82-year-old, nondiabetic woman who had taken ramipril 5 mg with amiloride 5 mg for two months was admitted...
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A Case of Liddle's Syndrome in a Seventy One-year Old Woman

Paik WH, Kim YW, Hong SC, Park SJ, Kim YK, Kim S, Kim YJ, Cho MG, Lee GJ

  • KMID: 1610213
  • Korean J Nephrol.
  • 2003 Jul;22(4):464-468.
Liddle's syndrome is a rare inherited disease with characteristic clinical manifestations of hypertension and hypokalemic metabolic alkalosis. Markedly suppressed serum aldosterone and renin levels are important laboratory findings to differentiate...
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Effect of Rhinovirus-16 Infection on the Electrophysiological Property of Cultured Tracheal Epithelial Cells

Jang YJ, Widdicombe JH

  • KMID: 1923106
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 Mar;46(3):211-215.
BACKGROUND AND OBJECTIVES: Rhinovirus infection on the airway epithelial cells results in derangement in mucociliary clearance. However, the contribution of altered ion transport across the epithelial cells in rhinovirus-induced alteration...
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A Case of Congenital Partial Nephrogenic Diabetes Insipidus

Kim JS, Kim SH, Han DK, Woo YJ

  • KMID: 2274982
  • Chonnam Med J.
  • 2002 Sep;38(3):280-284.
Congenital nephrogenic diabetes insipidus (NDI) is a rare hereditary disorder characterized by polyuria and polydipsia resulting from the failure of the distal renal tubules and collecting ducts to concentrate urine...
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Intracellular Aciditfication Induces PC12 cell Apoptosis Through p38 Kinase Activation

Bae WY, Chay KO, lee KY

  • KMID: 2172396
  • Chonnam Med J.
  • 2001 Dec;37(4):335-343.
No abstract available.
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A Case of Congenital Nephrogenic Diabetes Insipidus with Megaureter and Megabladder

Rhee EJ, Lee KB, Suh JY, Kim H, Park HJ, Kim YH, Kwon CH, Lee YR

  • KMID: 2079193
  • Korean J Nephrol.
  • 2001 Jul;20(4):723-727.
A case of a 37 year-old man of congenital diabetes insipidus is reported. He complained of polydipsia, which began from his youth, drinking about 10 L of water every day....
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The Inhibitory Effect of Amiloride on the Growth of Human Gastric Carcinoma Cells in Vitro

Kang SS, Kong DK, No CW, Choi BJ, Park MI, Park SJ, Park KY, Koo JY

  • KMID: 2174985
  • J Korean Cancer Assoc.
  • 2001 Apr;33(2):113-120.
PURPOSE: In the present study the effects of amiloride on the growth of human gastric adenocarcinoma cell line, AGS cells were examined with or without the addition of 5-fluorouracil (5-FU)...
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