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Immunologic Evaluation of Ofloxacin Hypersensitivity

Nam YH, Kim JE, Kim SH, Jin HJ, Hwang EK, Shin YS, Ye YM, Park HS

Quinolone hypersensitivity, most of which is immediate type, is rare but has increased in recent years. The pathogenic mechanisms underlying immediate reactions are not defined clearly. This study was aimed...
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ABCC2 Haplotype is Associated With Antituberculosis Drug-Induced Maculopapular Eruption

Kim SH, Jee YK, Lee JH, Lee BH, Kim YS, Park JS, Kim SH

Genetic variants in ATP-binding cassette (ABC) transporter genes are associated with increased susceptibility to adverse drug reactions. We hypothesized that genetic variant ABC transporters (ABCB1 and ABCC2) may be candidate...
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Effects of Omalizumab Treatment in Patients With Refractory Chronic Urticaria

Nam YH, Kim JH, Jin HJ, Hwang EK, Shin YS, Ye YM, Park HS

PURPOSE: Chronic urticaria (CU) is a common and debilitating disease, and the need for effective treatment has increased. Omalizumab may be an alternative regimen in patients with CU who do...
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Elevated Serum Levels of IL-21 in Kawasaki Disease

Bae YJ, Kim MH, Lee HY, Uh Y, Namgoong M, Cha BH, Chun JK

PURPOSE: The serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related...
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Standardization of House Dust Mite Extracts in Korea

Jeong KY, Choi SY, Lee JH, Lee IY, Yong TS, Lee JS, Hong CS, Park JW

PURPOSE: House dust mites are the most important cause of respiratory allergy in Korea. Standardization of allergen extracts is essential for improving diagnostics and immunotherapeutics. This study was undertaken to...
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Bronchial Hyperresponsiveness to Methacholine and AMP in Children With Atopic Asthma

Kang SH, Kim HY, Seo JH, Kwon JW, Jung YH, Song YH, Hong SJ

PURPOSE: Bronchial hyperresponsiveness (BHR) is typically measured by bronchial challenge tests that employ direct stimulation by methacholine or indirect stimulation by adenosine 5'-monophosphate (AMP). Some studies have shown that the...
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Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens

Kashiwakura Ji, Okayama Y, Furue M, Kabashima , Shimada S, Ra C, Siraganian RP, Kawakami Y, Kawakami T

PURPOSE: Monomeric IgE molecules, when bound to the high-affinity receptor, exhibit a vast heterogeneity in their ability to induce survival promotion and cytokine production in mast cells. At one end...
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Treatment of Chronic Spontaneous Urticaria

Kaplan AP

Chronic spontaneous urticaria is defined as persistent symptoms of urticaria for 6 weeks or more. It is associated with autoimmunity in approximately 45 percent of patients. Therapy is often difficult...
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House Dust Mite Allergy in Korea: The Most Important Inhalant Allergen in Current and Future

Jeong KY, Park JW, Hong CS

The house-dust mite (HDM), commonly found in human dwellings, is an important source of inhalant and contact allergens. In this report, the importance of HDM allergy in Korea and the...
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Highly Cytokinergic IgE Antibodies and Autoimmune Mechanisms

Kim MA, Park HS

No abstract available.
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