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The paradoxical effect of aldosterone on cardiovascular outcome in maintenance hemodialysis patients

Choi SR, Lee YK, Park HC, Kim DH, Cho A, Kim J, Yun KS, Noh JW, Kang MK

Background: Patients with end-stage kidney disease face increased risk of cardiovascular events, and left ventricular diastolic dysfunction (LVDD) contributes to the high occurrence of cardiovascular mortality (CM). Although a high...
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Angiotensin receptor-neprilysin inhibitor in patients with heart failure and chronic kidney disease

Cho IJ, Kang SM

Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), there remains an enormous health problem with high morbidity and mortality over the last few decades....
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Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism

Naruse M, Tanabe A, Yamamoto K, Rakugi H, Kometani M, Yoneda T, Kobayashi H, Abe M, Ohno Y, Inagaki N, Izawa S, Sone M

Adrenal venous sampling (AVS) is the key procedure for lateralization of primary hyperaldosteronism (PA) before surgery. Identification of the adrenal veins using computed tomography (CT) and intraoperative cortisol assay facilitates...
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Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor

Lee JY, Kim DA, Choi E, Lee YS, Park SJ, Kim BJ

Background: Despite clinical evidence indicating poor muscle health in subjects with primary aldosteronism (PA), it is still unclear whether the role of aldosterone in muscle metabolism is direct or mediated...
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Diagnostic Accuracy of Computed Tomography in Predicting Primary Aldosteronism Subtype According to Age

Lee SH, Kim JW, Yoon HK, Koh JM, Shin CS, Kim SW, Kim JH

Background: Guidelines by the Endocrine Society Guideline on bypassing adrenal vein sampling (AVS) in patients
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The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging

Gao X, Yamazaki Y, Tezuka Y, Omata K, Ono Y, Morimoto R, Nakamura Y, Satoh F, Sasano H

Primary aldosteronism (PA) is the most common cause of secondary hypertension, and is associated with an increased incidence of cardiovascular events. PA itself is clinically classified into the following two...
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Aldosterone Rapidly Enhances Levels of the Striatin and Caveolin-1 Proteins in Rat Kidney: The Role of the Mineralocorticoid Receptor

Inthachart K, Manotham K, Eiam-Ong S, Eiam-Ong S

BACKGROUND: Striatin and caveolin-1 (cav-1) are scaffolding/regulating proteins that are associated with salt-sensitive high blood pressure and promote renal sodium and water reabsorption, respectively. The mineralocorticoid receptor (MR) interacts with...
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Independent Association of Serum Aldosterone Level with Metabolic Syndrome and Insulin Resistance in Korean Adults

Min SH, Kim SH, Jeong IK, Cho HC, Jeong JO, Lee JH, Kang HJ, Kim HS, Park KS, Lim S

BACKGROUND AND OBJECTIVES: A relationship between renin-angiotensin system (RAS) components and metabolic syndrome (MetS) has been suggested, but not elucidated clearly. We examined the levels of RAS components in patients...
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Antihypertensive effect of Ganjang (traditional Korean soy sauce) on Sprague-Dawley Rats

Mun EG, Sohn HS, Kim MS, Cha YS

BACKGROUND/OBJECTIVES: Although Korean fermented foods contain large amounts of salt, which is known to exacerbate health problems, these foods still have beneficial effects such as anti-hypertension, anti-cancer, and anti-colitis properties....
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CTNNB1 Mutation in Aldosterone Producing Adenoma

Wang JJ, Peng KY, Wu VC, Tseng FY, Wu KD

Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described...
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Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock

Chung KS, Song JH, Jung WJ, Kim YS, Kim SK, Chang J, Park MS

BACKGROUND: The renin-angiotensin-aldosterone system is closely associated with volume status and vascular tone in septic shock. The present study aimed to assess whether plasma renin activity (PRA) and plasma aldosterone...
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Differences in left ventricular functional adaptation to arterial stiffness and neurohormonal activation in patients with hypertension: a study with two-dimensional layer-specific speckle tracking echocardiography

Kim D, Shim CY, Hong GR, Park S, Cho I, Chang HJ, Ha JW, Chung N

BACKGROUND: Arterial stiffness increases pressure load to the left ventricle (LV), leading to LV hypertrophy and subendocardial ischemia. Neurohormones stimulate myocardial fibrosis and LV dysfunction. We aimed to explore the...
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Diagnostic Role of Captopril Challenge Test in Korean Subjects with High Aldosterone-to-Renin Ratios

Kim JH, Park KS, Hong AR, Shin CS, Kim SY, Kim SW

BACKGROUND: Diagnosis of primary aldosteronism (PA) begins with aldosterone-to-renin ratio (ARR) measurement followed by confirmative tests. However, the ARR has high false positive rates which led to unnecessary confirmatory tests....
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Effect of aldosterone on epithelial-to-mesenchymal transition of human peritoneal mesothelial cells

Yu M, Shin HS, Lee HK, Ryu DR, Kim SJ, Choi KB, Kang DH

BACKGROUND: Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis. Epithelial-to-mesenchymal transition (EMT) of the peritoneum is an early and reversible mechanism of...
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Beneficial effects of ethanol extracts of Red Liriope platyphylla on vascular dysfunction in the aorta of spontaneously hypertensive rats

Lee YJ, Koh EK, Kim JE, Go J, Song SH, Seong JE, Son HJ, Kang BC, Hwang DY

Some biological effects of Red Liriope platyphylla (RLP) on various chronic diseases including Alzheimer's disease, diabetes and obesity were suggested after a report of the production from Liriope platyphylla (L....
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Obesity Associated Hypertension: New Insights into Mechanism

Kang YS

With excess nutrition, the burden of obesity is a growing problem worldwide. The imbalance between energy intake and expenditure leads to variable disorders as all major risk factors for cardiovascular...
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Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension

Moon JY

The activation of renin-angiotensin-aldosterine system(RAAS) is one of the main pathogenesis of hypertension. All the components of RAAS are present in the kidneys at higher concentrations compared to plasma levels,...
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Pseudohypoaldosteronism Type 1

Cheong HI

Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension....
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Clinical characteristics and follow-up of Korean patients with adrenal incidentalomas

Cho YY, Suh S, Joung JY, Jeong H, Je D, Yoo H, Park TK, Min YK, Kim KW, Kim JH

BACKGROUND/AIMS: We investigated the clinical characteristics and follow-up findings of subjects with adrenal incidentalomas in a single, tertiary-care hospital in South Korea. METHODS: The study consisted of a retrospective analysis of...
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A Case of Adrenocortical Carcinoma Secreting Cortisol and Aldosterone

Ha J, Kim MK, Cha YJ, Kim SK, Yun GY, Rhee K, Park JS, Cho ES, Ahn CW, Park JS

Adrenocortical carcinomas are rare and frequently aggressive tumors that may be functional (hormone-secreting) and may cause Cushing's syndrome or virilization, or non-functional and manifest as an abdominal mass. This paper...
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