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Neurobiological Basis of Craving and Anti-Craving Medications

Jung YC

Clinical studies published over the past two decades have consistently demonstrated the therapeutic efficacy and safety of anti-craving medications. To use anti-craving agents more effectively in clinical settings, it is...
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Bilateral Hearing Loss in Wernicke Encephalopathy

Bae H, Park JY, Cho HS, Lim SH, Ha SW

Wernicke encephalopathy is a syndrome caused by thiamine deficiency whose three typical symptoms are ophthalomoplegia, ataxia, and confusion. There are also rare reports of bilateral hearing loss, which can be...
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Delta Neutrophil Index is Useful to Predict Poor Outcomes in Male Patients with Alcoholic Ketoacidosis

Kim MK, Shin HW, Kim YJ, Yang JW, Kim JS, Han BG, Choi SO, Lee JY

BACKGROUND: Alcoholic ketoacidosis (AKA) is known as a benign disease, but the related mortality reported in Korea is high. Acidosis and alcohol change the immunity profile, and these changes can...
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Associations of Spiritual Well-being, Attitude toward Death and Quality of Life among Alcoholics Anonymous

Lee S, Gang M

PURPOSE: The aim of the study was to investigate associations of spiritual well-being, attitude toward death, and quality of life among Alcoholics Anonymous (AA). METHODS: This study was cross-sectional and descriptive...
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Hepatic Failure Due to Hepatitis E Virus Infection in a Patient with Necrotic Hepatocellular Carcinoma

Kim JH, Doh YS, Jang JW, Kang MS, Kim NM, Kim SH, Baek IH, Jung SH

In patients with hepatocellular carcinoma (HCC) or liver cirrhosis (LC) accompanied by hepatitis E virus (HEV) infection, hepatic failure often leads to debility. Here, we report about a 63-year-old man...
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An Integrative Literature Review of Resilience in Adult Children of Alcoholics: Focusing on Operational Definitions and Moderators

Kim HK, Ko Y

PURPOSE: The objective of this study was to explore operational definitions and moderators of the resilience of adult children of alcoholics (ACOA) and its associated variables. METHODS: This integrative review was...
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Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases

Yi HS

The signaling network of the mitochondrial unfolded protein response (UPR(mt)) and mitohormesis is a retrograde signaling pathway through which mitochondria-to-nucleus communication occurs in organisms. Recently, it has been shown that...
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Replantation of the Completely Amputated Adult Penis: Two Case Reports Using Microsurgical Technique

Lee DW, Hong SW, Kim JH

Traumatic penile amputation is a rare but catastrophic event, so all possible attempts should be made for salvage. Recent use of microsurgical methods have the potential to reduce complications, but...
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The Clock Is Ticking – Brain Atrophy in Case of Acute Trauma?

Nikova AS, Sioutas G, Kotopoulos K, Ganchev D, Chatzipaulou V, Birbilis T

OBJECTIVE: Brain atrophy and brain herniation are gaining a lot of attention separately, but a limited amount of studies connected them together, and because of this, we are going to...
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Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis

Schlossberger V, Worni M, Kihm C, Montani M, Datz C, Hampe J, Stickel F

BACKGROUND/AIMS: Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments...
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Measuring Intrahepatic Vascular Changes Using Contrast-Enhanced Ultrasonography to Predict the Prognosis of Alcoholic Hepatitis Combined with Cirrhosis: A Prospective Pilot Study

Park MS, Hong S, Lim YL, Kang SH, Baik SK, Kim MY

BACKGROUND/AIMS: Acute hepatic dysfunction combined with alcoholic hepatitis (AH) in alcoholic cirrhosis is related to hepatic hypo-perfusion secondary to intrahepatic necroinflammation, neoangiogenesis, and shunt. The hepatic vein arrival time (HVAT)...
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Adaptation Process in the Workplace in Korean Adults with Alcohol Use Disorder

Cho MS, An HJ

PURPOSE: This purpose of study was to describe the adaptation process in the workplace in Korean adults with alcohol use disorder. METHODS: Twelve participants were recruited at hospital outpatients, Alcoholic Anonymous,...
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Microbiota, a key player in alcoholic liver disease

Cassard AM, Ciocan D

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis. The intestinal microbiota (IM) has been recently...
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Epidemiology of alcoholic liver disease in Korea

Jang JY, Kim DJ

Alcohol consumption has increased over the past 40 years in Korea concomitantly with the country's rapid socioeconomic development. As a result, alcohol-related deaths and mortality continue to increase in Korea....
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Experiences of Overcoming Alcoholism in Alcoholics' Female Spouses Using Al-Anon

Sim JE, Hwang SY

PURPOSE: The aim of this study is to investigate and elucidate actual experiences of alcoholics' spouses using familial social gatherings. METHODS: A total of nine women whose alcoholic husbands were attending...
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Development and Evaluation of Group Counseling Program using Neurolinguistic Programming for Alcoholics

Kim H, Bae J

PURPOSE: The aim of this study was to develop and evaluate the effectiveness of a group counseling program using neurolinguistic programming (NLP) for individuals abusing alcohol. METHODS: In a quasi-experimental study,...
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Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Yu JY, Nguyen HT, Yong CS, Park HG, Jun JH, Kim JO

Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason...
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Neuropsychological Performance in Alcohol Dependent Patients: A One-Year Longitudinal Study

Ioime L, Guglielmo , Affini GF, Quatrale M, Martinotti G, Callea A, Savi E, Janiri L

OBJECTIVE: Despite several studies that have highlighted the harmful effects of alcohol consumption on cognitive functions it remains unclear whether certain brain areas are more sensitive than others are or...
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Role of liver transplantation in severe alcoholic hepatitis

Daswani R, Kumar A, Sharma P, Singla V, Bansal N, Arora A

Severe alcoholic hepatitis has very high short term mortality and corticosteroids have been the mainstay of treatment for decades. Patients with Lille score >0.45 are considered non-responders to steroids and...
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Abstinence Experience in Males with Alcohol Use Disorder

Joung HJ, Lee M, Kim HK, Lee EJ

PURPOSE: The purpose of this study was to explore the subjective experiences of those who are abstinent from alcohol to recover from alcoholism. METHODS: A qualitative descriptive study design was used. RESULTS:...
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