- Ampicillin treated German cockroach extract leads to reduced inflammation in human lung cells and a mouse model of Asthma
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- KMID: 2539992
- Parasit Host Dis.
- 2023 Feb;61(1):60-71.
- doi: 10.3347/PHD.22147
Cockroaches can cause allergic sensitization in humans via contact with their feces or frass. Antibiotics can affect concentration of major allergen and total bacteria production in German cockroaches (Blattella germanica).... -
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- Free-Living Amoeba Vermamoeba vermiformis Induces Allergic Airway Inflammation
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Lee DI, Park SH, Kang SA, Kim DH, Kim SH, Song SY, Lee SE, Yu HS
- KMID: 2533121
- Korean J Parasitol.
- 2022 Aug;60(4):229-239.
- doi: 10.3347/kjp.2022.60.4.229
The high percentage of Vermamoeba was found in tap water in Korea. This study investigated whether Vermamoeba induced allergic airway inflammation in mice. We selected 2 free-living amoebas (FLAs) isolated... -
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- STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
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Kim CH, Song KS
- KMID: 2532043
- Kosin Med J.
- 2022 Jun;37(2):134-139.
- doi: 10.7180/kmj.22.102
Background: Contact between the human pulmonary system and bacteria, viruses, or other pathogens can induce airway diseases. Although pathogen-induced mucus oversecretion and hyperproduction are frequently observed in the human respiratory... -
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- Serum Calprotectin Is a Potential Marker in Patients with Asthma
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Lee YG, Hong Js, Lee PH, Lee Jh, Park SW, Kim DJ, Jang AS
- KMID: 2508500
- J Korean Med Sci.
- 2020 Nov;35(43):e362.
- doi: 10.3346/jkms.2020.35.e362
Background: Calprotectin is the major cytosolic protein in neutrophil granulocytes. Although asthma is known to cause eosinophilic inflammation, some patients with asthma have non-eosinophilic inflammation, which is characterized by local neutrophilic... -
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- Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo
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Lee J, Mandava S, Ahn SH, Bae MA, So KS, Kwon KS, Kim HP
- KMID: 2503474
- Biomol Ther.
- 2020 Jul;28(4):344-353.
- doi: 10.4062/biomolther.2019.212
This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives,... -
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- Evaluation of Human MSCs Treatment Frequency on Airway Inflammation in a Mouse Model of Acute Asthma
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Hur J, Kang JY, Kim YK, Lee SY, Jeon S, Kim Y, Jung CK, Rhee CK
- KMID: 2502923
- J Korean Med Sci.
- 2020 Jun;35(23):e188.
- doi: 10.3346/jkms.2020.35.e188
Background: Studies in experimental models of allergic asthma have shown that mesenchymal stem cells (MSCs) have therapeutic potential for T-helper 2 (TH2) cell-mediated inflammation. However, the mechanisms underlying these therapeutic... -
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- The Role of Autophagy in Eosinophilic Airway Inflammation
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Lee J, Kim HS
- KMID: 2438913
- Immune Netw.
- 2019 Feb;19(1):e5.
- doi: 10.4110/in.2019.19.e5
Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory... -
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- Protective effect of water extract of guibi-tang against pulmonary inflammation induced by cigarette smoke and lipopolysaccharide
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Shin NR, Jung TY, Seo CS, Park SW, Ko JW, Kim JC, Shin IS
- KMID: 2420821
- Lab Anim Res.
- 2018 Sep;34(3):92-100.
- doi: 10.5625/lar.2018.34.3.92
Water extract of guibi-tang (GB), a traditional Chinese, Japanese, and Korean herbal medicine, is used to treat memory impairment, insomnia, and peptic ulcers. The aim of this study was to... -
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- Administration of Pigment Epithelium-Derived Factor Inhibits Airway Inflammation and Remodeling in Chronic OVA-Induced Mice via VEGF Suppression
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Zha W, Su M, Huang M, Cai J, Du Q
- KMID: 2165933
- Allergy Asthma Immunol Res.
- 2016 Mar;8(2):161-169.
- doi: 10.4168/aair.2016.8.2.161
PURPOSE: Pigment epithelium-derived factor (PEDF) is a recently discovered antiangiogenesis protein. PEDF possesses powerful anti-inflammatory, antioxidative, antiangiogenic, and antifibrosis properties. It has been reported that PEDF can regulate vascular endothelial... -
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- TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice
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Kim TH, Kim DJ, Park JH, Park JH
- KMID: 2391721
- Immune Netw.
- 2014 Oct;14(5):249-254.
- doi: 10.4110/in.2014.14.5.249
Allergic asthma is a chronic pulmonary inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness and eosinophils infiltration. Toll-like receptors (TLRs) signaling are closely associated with asthma and have emerged as... -
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- Receptor Interacting Protein 2 (RIP2) Is Dispensable for OVA-Induced Airway Inflammation in Mice
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Kim TH, Park YM, Ryu SW, Kim DJ, Park JH, Park JH
- KMID: 2260262
- Allergy Asthma Immunol Res.
- 2014 Mar;6(2):163-168.
- doi: 10.4168/aair.2014.6.2.163
PURPOSE: Asthma is a pulmonary chronic inflammatory disease characterized by airway obstruction and hyperresponsiveness. Pattern recognition receptors are known to play a key role in the development of allergic diseases... -
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- Asian Sand Dust Enhances Allergen-Induced Th2 Allergic Inflammatory Changes and Mucin Production in BALB/c Mouse Lungs
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Kang IG, Jung JH, Kim ST
- KMID: 1970709
- Allergy Asthma Immunol Res.
- 2012 Jul;4(4):206-213.
- doi: 10.4168/aair.2012.4.4.206
PURPOSE: Recent studies have reported that Asian sand dust (ASD) has a potential risk of aggravating airway inflammation. The purpose of this study was to investigate the effect of ASD... -
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- A 24 kDa Excretory-Secretory Protein of Anisakis simplex Larvae Could Elicit Allergic Airway Inflammation in Mice
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Park HK, Cho MK, Park MK, Kang SA, Kim YS, Kim KU, Lee MK, Ock MS, Cha HJ, Yu HS
- KMID: 1715742
- Korean J Parasitol.
- 2011 Dec;49(4):373-380.
- doi: 10.3347/kjp.2011.49.4.373
We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means... -
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- Enhancement of Allergen-induced Airway Inflammation by NOX2 Deficiency
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Won HY, Jang EJ, Min HJ, Hwang ES
- KMID: 2150704
- Immune Netw.
- 2011 Jun;11(3):169-174.
- doi: 10.4110/in.2011.11.3.169
BACKGROUND: NADPH oxidase (NOX) modulates cell proliferation, differentiation and immune response through generation of reactive oxygen species. Particularly, NOX2 is recently reported to be important for regulating Treg cell differentiation... -
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- Alveolar macrophages modulate allergic inflammation in a murine model of asthma
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Bang BR, Chun E, Shim EJ, Lee HS, Lee SY, Cho SH, Min KU, Kim YY, Park HW
- KMID: 1009966
- Exp Mol Med.
- 2011 May;43(5):275-280.
- doi: 10.3858/emm.2011.43.5.028
The role of alveolar macrophages (AMs) in the pathogenesis of asthma is still unknown. The aim of the present study was to investigate the effects of AM in the murine... -
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- Effects of Bacillus Calmette-Guerin (BCG) Vaccination according to Time Point of Administration on Asthma in a Murine Model
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- KMID: 2299527
- Korean J Asthma Allergy Clin Immunol.
- 2010 Dec;30(4):307-313.
BACKGROUND: Asthma is a chronic allergic disease characterized by the infiltration of eosinophils into the airway and lung. Bacille Calmette-Guerin (BCG) has been reported to be beneficial to inhibit allergic... -
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- The Role of Oxidative Stress in the Pathogenesis of Asthma
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Cho YS, Moon HB
- KMID: 2133806
- Allergy Asthma Immunol Res.
- 2010 Jul;2(3):183-187.
- doi: 10.4168/aair.2010.2.3.183
Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the... -
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- A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
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Holgate ST
- KMID: 2133803
- Allergy Asthma Immunol Res.
- 2010 Jul;2(3):165-171.
- doi: 10.4168/aair.2010.2.3.165
The original concept of asthma being primarily a disease of airways smooth muscle drove the development of bronchodilator drugs. However when it was realised that airway inflammation underpinned the disordered... -
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- Effects of Korean Red Ginseng Extracts on Airway Hyperresponsiveness and Inflammation in a Murine Asthma Model
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- KMID: 2146036
- Korean J Asthma Allergy Clin Immunol.
- 2010 Mar;30(1):43-49.
BACKGROUND: The morbidity associated with asthma is still high, despite improvements in understanding of the disease and the development of new drugs. Therefore, many sufferers turn to alternative or complementary... -
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- The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma
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Nam HS, Lee SY, Kim SJ, Kim JS, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH, Kim SC
- KMID: 1758619
- Yonsei Med J.
- 2009 Aug;50(4):569-575.
- doi: 10.3349/ymj.2009.50.4.569
PURPOSE: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-alpha blocking strategies are now being tried in... -
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