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Cytoprotective and antioxidant effects of aged garlic extract against adriamycin-induced cardiotoxicity in adult male rats

Nasr AY, Alshali RA

Adriamycin (ADR) efficacy in cancer chemotherapy is well-established. However, ADR-induced cardiotoxicity remains a significant challenge. Aged garlic extract (AGE) is a natural polyphenol with high antioxidant potential. This study was...
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Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy

Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS

The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression...
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Histological Experimental Study on the Effect of Stem Cell Therapy on Adriamycin Induced Chemobrain

Zickri1 MB, Abd El Aziz DH, Metwally H

  • KMID: 2054550
  • Int J Stem Cells.
  • 2013 Nov;6(2):104-112.
BACKGROUND AND OBJECTIVES: Negative consequences of chemotherapy on brain function were suggested and were addressed in animal models as the clinical phenomenon of chemobrain .It was postulated that adriamycin (ADR)...
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Effect of Stem Cell Therapy on Adriamycin Induced Tubulointerstitial Injury

Zickri MB, Zaghloul S, Farouk M, Abdel Fattah MM

  • KMID: 1735407
  • Int J Stem Cells.
  • 2012 Nov;5(2):130-139.
BACKGROUND AND OBJECTIVES: It was postulated that adriamycin (ADR) induce renal tubulointerstitial injury. Clinicians are faced with a challenge in producing response in renal patients and slowing or halting the...
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Tissue Regeneration and Stem Cell Distribution in Adriamycin Induced Glomerulopathy

Zickri MB, Abdel Fattah MM, Metwally H

  • KMID: 1735405
  • Int J Stem Cells.
  • 2012 Nov;5(2):115-124.
BACKGROUND AND OBJECTIVES: Glomerulosclerosis develops secondary to various kidney diseases. It was postulated that adriamycin (ADR) induce chronic glomerulopathy. Treatment combinations for one year did not significantly modify renal function...
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The Comparative Study of Treatment Method on Adriamycin-Induced Extravasation Injury

Moon IS, Lee CH, Kwon YS, Lee KC, Kim SK

  • KMID: 1920340
  • J Korean Soc Plast Reconstr Surg.
  • 2009 May;36(3):269-276.
PURPOSE: Local skin necrosis after extravasation of adriamycin, a widely used chemotherapeutic agent, is a common problem in cancer patients. The extravasation of chemotherapeutic agents yields severe inflammatory responses, crust...
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The Expression of Cardiac Ankyrin Repeat Protein in an Animal Model of Adriamycin-Induced Cardiomyopathy

Chung WB, Youn HJ, Choi YS, Park CS, Oh YS, Chung WS, Kim JH, Lee EH

BACKGROUND AND OBJECTIVES: Cardiac ankyrin repeat protein (CARP) is an embryonic nuclear protein, and its expression is increased under conditions of pressure or volume overload and also in the failing...
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Effects of Cardiotrophin-1 on Adriamycin-Induced Apoptosis in H9c2 Cardiomyoblasts

Shin JO, Ju ES, Song HM, Yun SH, Lim BK, Choi JH, Kim DK, Jeon ES

BACKGROUND AND OBJECTIVES: Adriamycin (doxorubicin, ADR) is a highly effective anti-neoplastic drug, but its clinical use is limited by its adverse side effects on the heart. Cardiotrophin (CT-1), a potent...
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Gene Expression Changes of Drug-resistant Saos-2 Cells Induced by Anticancer Drug

Bae MJ, Song IH, Kim SY

  • KMID: 2128893
  • Korean J Anat.
  • 2007 Dec;40(4):297-310.
During the treatment of cancers, especially with anticancer drugs, the recurrence of cancer is the most important factor for survival rate. The most common cause of the recurrence is the...
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Gene Expression of Metalloproteinases, Tissue Inhibitors of Metalloproteinases and Cytokines in Adriamycin-induced Cardiomyopathy

Hong YM

  • KMID: 2278660
  • Korean J Pediatr.
  • 2005 Feb;48(2):197-203.
PURPOSE: Changes in metalloproteinases(MMP) activity have been demonstrated in several disease states, including rheumatoid arthritis and tumor metastasis. More importantly, increased myocardial MMP activity has been reported to occur in...
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Effects of Adriamycin or CP-2 to the Rectal Mucosae of Mouse Implanted with Ehrlich Carcinoma Cells: An Autoradiographic Study

Wang JW, Ko JS, Ahn ET, Park KH, Park DK

  • KMID: 2224487
  • Korean J Anat.
  • 2005 Dec;38(6):505-514.
This experiment was performed to evaluate the morphological responses of the rectal intestinal glands of the mouse, inoculated with Ehrlich carcinoma cells, following administration of adriamycin or composition of the...
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Effects of Antitumor Agents to DNA Synthesis in the Gastric Epithelia of Mice Implanted with Ehrlich Carcinoma Cells: An Autoradiographic Study

Ko JS, Choi PC, Ahn ET, Park KH, Park DK

  • KMID: 2224486
  • Korean J Anat.
  • 2005 Dec;38(6):495-504.
This experiment was performed to evaluate the morphological responses of the gastric epithelium of the mouse, inoculated with Ehrlich carcinoma cells, following administration of 5-fluorouracil, adriamycin or mitomycin C. Healthy...
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The Preventive Effect of Dexrazoxane and Pentoxifylline on Adriamycin Induced Cardiomyopathy

Ling Z, Bae EJ, Ha IS, Seo JW, Noh CI, Choi JY, Yun YS

  • KMID: 1313594
  • Korean J Pediatr.
  • 2005 Dec;48(12):1378-1384.
PURPOSE: We hypothesized dexrazoxane (DXR) and pentoxifylline (PTX) may prevent myocardial damage in adriamycin (ADR) -induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis...
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Effects of Renin-angiotensin System Blockade on Tubulointerstitial Lesions in Adriamycin-induced Nephropathy

Lee DK, Han SW, Paik SS, Park MH, Lee JU, Kim HJ

  • KMID: 2079422
  • Korean J Nephrol.
  • 2005 Jan;24(1):26-31.
PURPOSE: Effects of renin-angiotensin system blockade on tubulointerstitial lesions were examined in adriamycin-induced nephropathy. METHODS: Male Sprague-Dawley rats were used. The three experimental groups were intravenously injected with adriamycin (2...
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The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray

Ahn MJ, Lee KH, Ahn JI, Yu DH, Lee HS, Choi JH, Jang JS, Bae JM, Lee YS

  • KMID: 1807305
  • Cancer Res Treat.
  • 2004 Feb;36(1):43-49.
PURPOSE: Adriamycin(R) is one of the most commonly used drugs in the treatment of breast cancer. This study was performed to understand the molecular mechanisms of drug resistance in breast...
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Adriamycin Induced Apoptosis of H9c2 Cardiomyocytes via a Caspase-Independent Pathway

Jeon MH, Youn HJ, Lee JH, Lee JH

BACKGROUND: The cardiotoxicity of adriamycin limits its clinical usefulness as a powerful drug for solid tumors and malignant hematological disease. Although the exact mechanism by which it causes cardiac damage...
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Retrospective Study on the Therapeutic Effects of an Etoposide, Adriamycin, Cisplatin-II (EAP- II) versus an Etoposide, Leucovorin, 5-Furorouracil (ELF) Combination Chemotheraphy in Unresectable Gastric Cancer

Moon HS, Kang YS, Kim YS, Park KO, Lee ES, Sung JK, Lee BS, Noh SM, Song KS, Cho JS, Shin KS, Jeong HY

  • KMID: 1515760
  • J Korean Gastric Cancer Assoc.
  • 2003 Sep;3(3):122-127.
PURPOSE: The incidence rate and the mortality rate of gastric cancer have decreased in developed countries over the last several decades. On the other hand, they remain high in far...
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Effects of Adriamycin or CP -2 on the Spleen of Mouse Implanted with Ehrlich Carcinoma Cells: An Autoradiographic Study

Ko JS, Ahn ET, Park KH, Kim JG

  • KMID: 2283132
  • Korean J Phys Anthropol.
  • 2002 Sep;15(3):185-195.
In this experiment, side effects of two anticancer drugs (adriamycin and CP -2) on the structure of spleen were histologically studied. Each of ICR mice was inoculated with 1 x10...
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The Antiapoptotic Effect of Vascular Endothelial Growth Factor and Angiopoietin-1 on Glomerular Endothelial Cells in Adriamycin or Cisplatin-induced Apoptosis

Kim W, Lim CS, Sung MJ, Kim SH, Moon SO, Lee S, La BJ, Park SK, Kang SK, Kim HJ, Koh GY

  • KMID: 2254393
  • Korean J Nephrol.
  • 2002 Jul;21(4):569-583.
BACKGROUND: Because glomerular endothelium play a pivotal role in the renal diseases, damage of glomerular endothelial cells lead to progression of glomerular sclerosis and decrement of renal function. Apoptotic damage...
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Retinoic Acid Enhances Drug-Induced Cell Death in Anticancer Drug-Resistant Cell Lines

Whang YM, Kim YH, Shin SW, Kim BS, Kim JS, Yoo YD, Park SH

  • KMID: 2134356
  • Cancer Res Treat.
  • 2002 Jun;34(3):212-217.
PURPOSE: Retinoids (RA), a group of vitamin A derivatives, is known to be important for regulation of normal cellular growth and differentiation. RA treatment of various cancers resulted in cell...
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