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Expression and Regulation of Osteoprotegerin in Adipose Tissue

An JJ, Han DH, Kim DM, Kim SH, Rhee Y, Lee EJ, Lim SK

PURPOSE: Osteoprotegerin (OPG), a potent inhibitor of osteoclastic bone resorption, has a variety of biological functions that include anti-inflammatory effects. Adipocytes and osteoblasts share a common origin, and the...
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Inflammatory Gene Expression Patterns Revealed by DNA Microarray Analysis in TNF-alpha-treated SGBS Human Adipocytes

Do MS, Jeong HS, Choi BH, Hunter L, Langley S, Pazmany L, Trayhurn P

We report here the use of human inflammation arrays to study the inflammatory gene expression profile of TNF-alpha- treated human SGBS adipocytes. Human preadipocytes (SGBS) were induced to differentiate in...
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NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARg expression

Chae GN, Kwak SJ

  • KMID: 1093616
  • Exp Mol Med.
  • 2003 Oct;35(5):431-437.
TNF-alpha, a trimeric cytokine, was known to inhibit differention of preadipocytes to adipocytes. In the present study, we investigated signal mediators working downstream of TNF-alpha using murine 3T3-L1 cells. TNF-alpha...
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Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation

Kim JR, Ryu HH, Chung HJ, Lee JH, Kim SW, Kwun WH, Baek SH, Kim JH

  • KMID: 1111409
  • Exp Mol Med.
  • 2006 Apr;38(2):162-172.
People with upper body or visceral obesity have a much higher risk of morbidity and mortality from obesity-related metabolic disorders than those with lower body obesity. In an attempt to...
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