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Behavioral Deficits in Adolescent Mice after Sub-Chronic Administration of NMDA during Early Stage of Postnatal Development

Adil KJ, Remonde CG, Gonzales EL, Boo KJ, Kwon KJ, Kim DH, Kim HJ, Cheong JH, Shin CY, Jeon SJ

Neurodevelopmental disorders are complex conditions that pose difficulty in the modulation of proper motor, sensory and cognitive function due to dysregulated neuronal development. Previous studies have reported that an imbalance...
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Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice

Kim DG, Gonzales E, Kim S, Kim Y, Adil KJ, Jeon SJ, Cho KS, Kwon KJ, Shin CY

Sociability is the disposition to interact with one another. Rodents have a rich repertoire of social behaviors and demonstrate strong sociability. Various methods have been established to measure the sociability...
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Recapitulation of Neuropsychiatric Behavioral Features in Mice Using Acute Low-dose MK-801 Administration

Mabunga DF, Park D, Ryu O, Valencia S, Adil KJ, Kim S, Kwon KJ, Shin CY, Jeon SJ

Despite some innate limitations, animal models are a potent investigative tool when used to model specific symptoms of a disorder. For example, MK-801, an N-methyl-D-aspartate receptor antagonist, is used as...
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Comparative Behavioral Correlation of High and Low-Performing Mice in the Forced Swim Test

Valencia S, Gonzales E, Adil KJ, Jeon SJ, Kwon KJ, Cho KS, Shin CY

Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but...
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Sex-specific Behavioral Features of Rodent Models of Autism Spectrum Disorder

Jeon SJ, Gonzales E, Mabunga DF, Valencia S, Kim DG, Kim Y, Adil KJ, Shin D, Park D, Shin CY

Sex is an important factor in understanding the clinical presentation, management, and developmental trajectory of children with neuropsychiatric disorders. While much is known about the clinical and neurobehavioral profiles of...
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