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Usefulness of BRAF VE1 immunohistochemistry in non–small cell lung cancers: a multi-institutional study by 15 pathologists in Korea

Chang S, Choi YL, Shim HS, Lee GK, Ha SY, Korean Cardiopulmonary Pathology Study Group

Background: Next-generation sequencing (NGS) is an approved test to select patients for BRAF V600E targeted therapy in Korea. However, the high cost, long turnaround times, and the need for sophisticated...
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Scalp metastasis from an adenocarcinoma of the lung mimicking a cystic mass: case report and literature review

Kim HK, Kang SH, Kim WS, Kang SH, Kim WJ, Kim HS, Bae TH

A 67-year-old man visited our plastic surgery clinic complaining of a palpable protruding mass (2.0 × 2.5 cm) in the right occipital region. To establish an appropriate treatment plan for...
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Selection Strategies and Practical Application of BRAF V600E-Mutated Non–Small Cell Lung Carcinoma

Hwang I, Choi YL, Lee H, Hwang S, Lee B, Yang H, Chelakkot C, Han J

Purpose The incidence of BRAF V600E mutation in non-small cell lung carcinoma (NSCLC) is lower than 2%, which poses difficulties in finding legitimate patients for targeted therapy. We investigated the predictive...
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Semi-Quantitative Analysis for Determining the Optimal Threshold Value on CT to Measure the Solid Portion of Pulmonary Subsolid Nodules

Lee S, Lee DH, Lee JH, Lee S, Han K, Park CH, Kim TH

Purpose: This study aimed to investigate the optimal threshold value in Hounsfield units (HU) on CT to detect the solid components of pulmonary subsolid nodules using pathologic invasive foci as...
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A Case of Simultaneously Diagnosed Lung Adenocarcinoma and Endobronchial Inflammatory Myofibroblastic Tumor with Two Distinct Types of ALK Translocation

Zhao S, Liu W, Li S, Shi T, Chen Q, Li Q, Sun L, Ren D, Song Z, Huang C, Xu S

A 61-year-old male patient was simultaneously diagnosed with lung adenocarcinoma and inflammatory myofibroblastic tumor (IMT). The lung adenocarcinoma and IMT harbored two distinct types of ALK translocation, LOC101927285-ALK, and TPM3-ALK,...
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Volume and Mass Doubling Time of Lung Adenocarcinoma according to WHO Histologic Classification

Hong JH, Park S, Kim H, Goo JM, Park IK, Kang CH, Kim YT, Yoon SH

Objective: This study aimed to evaluate the tumor doubling time of invasive lung adenocarcinoma according to the International Association of the Study for Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory...
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Genetic Features of Lung Adenocarcinoma with GroundGlass Opacity: What Causes the Invasiveness of Lung Adenocarcinoma?

Kim D, Lee JY, Yoo JY, Cho JY

Background: Lung adenocarcinoma (LUAD) with ground-glass opacity (GGO) can become aggravated, but the reasons for this aggravation are not fully understood. The goal of this study was to analyze the...
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Genetic Alterations in Preinvasive Lung Synchronous Lesions

Ahn S, Lim J, Park SY, Kim H, Kwon HJ, Han YB, Lee CT, Cho S, Chung JH

Purpose Despite advances in treatment, lung cancer remains the leading cause of cancer mortality. This study aimed to characterise genome-wide tumorigenesis events and to understand the hypothesis of the multistep carcinogenesis...
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Expression of female sex hormone receptors and its relation to clinicopathological characteristics and prognosis of lung adenocarcinoma

Lee JH, Kim HK, Shin BK

Background: Adenocarcinoma (ADC) of the lung exhibits different clinicopathological characteristics in men and women. Recent studies have suggested that these differences originate from the expression of female sex hormone receptors...
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Circulating Tumor Cell Number Is Associated with Primary Tumor Volume in Patients with Lung Adenocarcinoma

Kang BJ, Ra SW, Lee K, Lim S, Son SH, Ahn JJ, Kim BC

BACKGROUND: Circulating tumor cells (CTCs) are frequently detected in patients with advanced-stage malignant tumors and could act as a predictor of poor prognosis. However, there is a paucity of data...
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Mechanisms of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance and Strategies to Overcome Resistance in Lung Adenocarcinoma

Chang YS, Choi CM, Lee JC

Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine...
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Three-Dimensional Ground Glass Opacity Ratio in CT Images Can Predict Tumor Invasiveness of Stage IA Lung Cancer

Yu WS, Hong SR, Lee JG, Lee JS, Jung HS, Kim DJ, Chung KY, Lee CY

PURPOSE: We investigated the relationship between various parameters, including volumetric parameters, and tumor invasiveness according to the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory...
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Uterine Cervix Metastasis in Lung Adenocarcinoma with Anaplastic Lymphoma Kinase Rearrangement

Choi S, Park CK, Kim SY, Yoon HK, Ro SM, Nam Y

The importance of anaplastic lymphoma kinase (ALK) as an oncogene in non-small cell lung cancer (NSCLC) has emerged as a major concern due to a dramatic clinical effect of targeted...
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Achalasia secondary to lung adenocarcinoma

Can B, Balli F, Korkmaz U, Yilmaz H, Can FI, Celebi A

No abstract available.
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Single Incision Thoracoscopic Left Lower Lobe Superior Segmentectomy for Non-Small Cell Lung Cancer

Jeon HW, Choi SH, Wang YP, Hyun KY

  • KMID: 2115252
  • Korean J Thorac Cardiovasc Surg.
  • 2014 Apr;47(2):185-188.
Lobectomy with mediastinal node dissection has been standard treatment for non-small cell lung cancer (NSCLC). Nowadays, video-assisted thoracoscopic surgery (VATS) is gaining acceptance as an alternative treatment option, given the...
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Late-Onset Distant Metastatic Upper Urinary Tract Urothelial Carcinoma Mimicking Lung Adenocarcinoma

Lim JH, Jeon SH, Lee JM, Kim L, Cho JH, Ryu JS, Kwak SM, Lee HL, Nam HS

  • KMID: 2320436
  • Tuberc Respir Dis.
  • 2013 Jul;75(1):32-35.
Urothelial carcinomas (UCs) can occur in the upper urinary tract or lower urinary tract. Upper urinary tract urothelial carcinoma (UUT-UC) is relatively a rare disease and accounts for only about...
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Predicting Survival in Patients with Advanced Non-squamous Non-small Cell Lung Cancer: Validating the Extent of Metastasis

Lee DS, Kang JH, Lee CG, Kim SJ, Choi YJ, Lee KY, Kim YS

  • KMID: 2167614
  • Cancer Res Treat.
  • 2013 Jun;45(2):95-102.
PURPOSE: A number of factors related to overall survival (OS) have been addressed in advanced non-small cell lung cancer (NSCLC). This study was conducted to determine the impact of whole-body...
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A Case of Synchronous Lung Adenocarcinoma and Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Type

Jung CY, Kwon KY

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (extranodal MZL) is a distinct subgroup of non-Hodgkin's lymphoma. Pulmonary extranodal MZL is a rare entity and accounts for less...
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Successful Rechallenge with Gefitinib for an Initial Erlotinib-Responder with Advanced Lung Adenocarcinoma

Hong SC, Sim YS, Lee JH, Ryu YJ, Chang JH

  • KMID: 2319566
  • Tuberc Respir Dis.
  • 2011 Oct;71(4):286-290.
Although failure of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKI) is generally believed to be associated with cross-resistance to other EGFR TKI, the benefit of administering erlotinib as...
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Metastasis to the Thyroid Gland in Patients with Metachronous Rectal Carcinoma and Adenocarcinoma of the Lungs

Bong J, Cho C, Park S

Metastasis to the thyroid gland is rare in clinical settings despite its rich vascular supply. A 60-year-old woman who had rectal cancer was diagnosed with thyroid malignancy with bilateral cervical...
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