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Differential Expression of Hypoxia Inducible Factor-1 alpha and Tumor Cell Proliferation Between Squamous Cell Carcinomas and Adenocarcinomas Among Operable Non-Small Cell Lung Carcinomas

Lee CH, Lee MK, Kang CD, Kim YD, Park DY, Kim JY, Sol MY, Suh KS

This study aimed to evaluate whether the elevated level of hypoxia-inducible factor-1 alpha (HIF-1 alpha) correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell...
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Correlation between expression of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) and angiogenesis in colorectal adenocarcinoma

Kim TS, Kim YB

Matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), which degrade extracellular matrix, are believed to play a crucial role in tumor invasion and metastasis. Angiogenesis is also perceived as an important...
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Expression of cyclin dependent kinase inhibitor p21WAF1 alone and in combination with p27KIP1 shows prognostic value in gastric carcinoma

Jang SJ, Ahn MJ, Paik SS, Kong G, Keum JS, Park YW, Lee JD

Evidence suggests that multiple molecular events, including alteration of cell cycle regulators are involved in the development and progression of gastric carcinoma. Recently, it has been reported that the...
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p21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP

Park YE, Choi KC, Choi YH

p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a...
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P53 overexpression in gastric adenocarcinoma with Helicobacter pylori infection

Chang KH, Kwon JW, Kim BS, Hwang JH, Lee SK, Lee YC, Park HJ, Park IS, Kim HK

Gastric carcinogenesis has been studied in various aspects. Helicobacter pylori (Hp) infection and mutation of the p53 tumor suppressor gene have recently been argued to be important factors...
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Cyclin E expression in benign and malignant epithelial neoplasms of the gallbladder

Jin YM, Yim H, Shim C

Cyclins are the regulatory subunits of cyclin-dependent kinase and play an important role in cell proliferation. Many tumors, such as colon, breast and gastric carcinomas are known to be involved...
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