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Pathogenesis and Management of Serrated Polyps: Current Status and Future Directions

Anderson J

Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in...
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Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis

Song JY, Bae HS, Koo DH, Lee JK, Jung HH, Lee KW, Lee NW

Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study...
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Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells

Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K

Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have...
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Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability

Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC

To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history...
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Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells

He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J

  • KMID: 1402316
  • Exp Mol Med.
  • 2012 Dec;44(12):723-732.
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors....
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