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Regulation of the expression and function of TRPCs and Orai1 by Homer2 in mouse pancreatic acinar cells

Kang JY, Kang N, Yang YM

Under physiological conditions, calcium (Ca2+ ) regulates essential functions of polarized secretory cells by the stimulation of specific Ca2+ signaling mechanisms, such as increases in intracellular Ca2+ concentration ([Ca2+]i )...
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Pancreatic Acinar Cell Cystadenoma Mimicking Pancreatic Serous Cystadenoma

Lee JH, Jung SJ, Park YH, Park SJ, Choi JS

Acinar cell cystadenoma, also known as an acinar cystic transformation of the pancreas, is an exceedingly rare but benign pancreatic lesion. A 51-year-old woman was transferred to Inje University Busan...
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Homer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells

Kang N, Kang JY, Shin DM, Yang YM

The salivary glands secrete saliva, which plays a role in the maintenance of a healthy oral environment. Under physiological conditions, saliva secretion within the acinar cells of the gland is...
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Hydrogen peroxide inhibits Ca²⁺ efflux through plasma membrane Ca²⁺-ATPase in mouse parotid acinar cells

Kim MJ, Choi KJ, Yoon MN, Oh SH, Kim DK, Kim SH, Park HS

Intracellular Ca²⁺ mobilization is closely linked with the initiation of salivary secretion in parotid acinar cells. Reactive oxygen species (ROS) are known to be related to a variety of oxidative...
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Peroxisome Proliferator-activated Receptor-gamma Inhibits the Activation of STAT3 in Cerulein-stimulated Pancreatic Acinar Cells

Ju KD, Lim JW, Kim H

Cerulein-induced pancreatitis is similar to human edematous pancreatitis, characterized by the dysregulation of digestive enzyme production, edema formation, and an infiltration of inflammatory cells into the pancreas. We previously showed...
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Hydrogen peroxide attenuates refilling of intracellular calcium store in mouse pancreatic acinar cells

Yoon MN, Kim DK, Kim SH, Park HS

Intracellular calcium (Ca²⁺) oscillation is an initial event in digestive enzyme secretion of pancreatic acinar cells. Reactive oxygen species are known to be associated with a variety of oxidative stress-induced...
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The Transcription Factor Mist1 Regulates the Cellular Polarity in Mouse Pancreatic Acinar Cells

Yang YM, Lee SI, Shin DM

  • KMID: 2009498
  • Int J Oral Biol.
  • 2012 Mar;37(1):37-41.
Pancreatic acinar cells exhibit a polarity that is characterized by the localization of secretory granules at the apical membrane. However, the factors that regulate cellular polarity in these cells are...
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Role of Regulators of G-Protein Signaling 4 in Ca2+ Signaling in Mouse Pancreatic Acinar Cells

Park S, Lee SI, Shin DM

Regulators of G-protein signaling (RGS) proteins are regulators of Ca2+ signaling that accelerate the GTPase activity of the G-protein alpha-subunit. RGS1, RGS2, RGS4, and RGS16 are expressed in the pancreas,...
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Membrane Proteome Analysis of Cerulein-Stimulated Pancreatic Acinar Cells: Implication for Early Event of Acute Pancreatitis

Lee J, Seo JH, Lim JW, Kim H

  • KMID: 2167210
  • Gut Liver.
  • 2010 Mar;4(1):84-93.
BACKGROUND/AIMS: Cerulein pancreatitis is similar to human edematous pancreatitis with dysregulation of the production and secretion of digestive enzymes, edema formation, cytoplasmic vacuolization and the death of acinar cells. We...
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Altered Gene Expression in Cerulein-Stimulated Pancreatic Acinar Cells: Pathologic Mechanism of Acute Pancreatitis

Yu JH, Lim JW, Kim H

Acute pancreatitis is a multifactorial disease associated with the premature activation of digestive enzymes. The genes expressed in pancreatic acinar cells determine the severity of the disease. The present study...
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Alteration of Expression of Ca(2+) Signaling Proteins and Adaptation of Ca(2+) Signaling in SERCA2(+/-) Mouse Parotid Acini

Choi JH, Jo H, Hong JH, Lee SI, Shin DM

PURPOSE: The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), encoded by ATP2A2, is an essential component for G-protein coupled receptor (GPCR)-dependent Ca(2+) signaling. However, whether the changes in Ca(2+) signaling and Ca(2+) signaling...
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Expression of Ca2+-dependent Synaptotagmin Isoforms in Mouse and Rat Parotid Acinar Cells

Jo H, Byun HM, Kim JH, Kim MS, Kim SH, Hong JH, Seo JT, Lee SI, Shin DM, Son HK

Synaptotagmin is a Ca2+ sensing protein, which triggers a fusion of synaptic vesicles in neuronal transmission. Little is known regarding the expression of Ca2+ - dependent synaptotagmin isoforms and their...
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Expression of volume-activated anion channels in exocrine acinar cells

Park K, Majid A

No abstract available.
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Modulation of InsP3 receptor properties by phosphorylation: targeting of PKA to InsP3 receptors shapes oscillatory calcium signals in pancreatic acinar cells

Giovannucci DR, Sneyd J, Groblewski GE, Yule DI

No abstract available.
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NF-kB and cytokines in pancreatic acinar cells

Kim H, Seo JY, Kim KH

Reactive oxygen species (ROS), generated by infiltrating neutrophils, are considered as an important regulator in the pathogenesis and deveolpment of pancreatitis. A hallmark of the inflammatory response is the induction...
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Molecular characterisation of pancreatic zymogen granule ion channel and regulator proteins involved in exocytosis

Thevenod F, Braun M, Roussa E, Fuller CM

In pancreatic acinar cells Ca(2+)-dependent secretagogues promote the fusion of zymogen granules (ZG) with the apical plasma membrane (PM) and exocytosis of digestive enzymes. In addition to exocytotic fusion complexes...
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The functional organisation of calcium signalling in exocrine acinar cells

Petersen O

No abstract available.
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