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Protective effect of low-intensity treadmill exercise against acetylcholine-calcium chloride-induced atrial fibrillation in mice

Sung DJ, Jeon YK, Choi J, Kim B, Golpasandi S, Park SW, Oh SB, Bae YM

Atrial fibrillation (AF) is the most common supraventricular arrhythmia, and it corresponds highly with exercise intensity. Here, we induced AF in mice using acetylcholine (ACh)-CaCl2 for 7 days and aimed...
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A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease

Ricci MF, Béla SR, Barbosa JL, Moraes MM, Mazzeti AL, Bahia MT, Horta LS, Santiago HdC, Cruz JS, Capettini LdSA, Arantes RME

  • KMID: 2531222
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):483-500.
  • doi: 10.5056/jnm21074
Background/Aims Chagasic megacolon is caused by Trypanosoma cruzi, which promotes in several cases, irreversible segmental colonic dilation. This alteration is the major anatomic-clinical disorder, characterized by the enteric nervous system and...
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Prokinetic Agents

Song HY, Jung SW, Kim YS

Gastrointestinal (GI) prokinetic agents are drugs that increase GI motility and promote the movement of contents in the GI tract by amplifying and controlling the contraction of GI smooth muscle....
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Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

Radhakrishnan RK, Ravichandran S, Sukesh A, Kadalmani B, Kandasamy M

Background: Botulinum toxin (BoNT) is a widely used therapeutic agent that blocks the excessive release of acetylcholine at the neuromuscular junction. Previously, repeated intracremasteric injections and slight overdose of BoNT...
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Safety and efficacy of low-dose aspirin in patients with coronary artery spasm: long-term clinical follow-up

Choi BG, Kim KH, Rha SW

Background: Aspirin is known to aggravate coronary artery spasm (CAS) regardless of the dose (100–325 mg/day). However, it is unclear whether low-dose aspirin (LDA; 100 mg) has deleterious impacts on...
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Liberation of Serotonin Is Not Unaffected by Acetylcholine in Rat Hippocampus

Kim JH, Ahn YS, Song YS

Purpose: Raised cerebral titers of acetylcholine have notable links with storage symptomatology related to lower urinary tract symptoms. The hippocampus contributes to the normal control of continence in the majority...
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Association Study of Polymorphisms in Neuronal Nicotinic Acetylcholine Receptor Subunit Genes With Schizophrenia in the Han Chinese Population

Li Yy, Geng Rj, Yu Sy, Li Gj, Wang Zy, Li Hf

Objective To investigate the relation between nicotinic acetylcholine receptor subunit (nAChR) genes and schizophrenia, and the relation between tag single nucleotide polymorphism (rs1317286, rs1044396, rs6494212, rs16969968, and rs684513) and schizophrenia...
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Effect of Varenicline on Tardive Dyskinesia: A Pilot Study

Caroff SN, Gutman AR, Northrop J, Leong SH, Berkowitz RM, Campbell EC

Objective: Although evidence implicates striatal cholinergic impairment as a mechanism underlying tardive dyskinesia, trials of nonspecific cholinergic agents have been inconclusive. As a partial agonist at specific nicotinic receptor subtypes,...
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Scientific review of the aesthetic uses of botulinum toxin type A

Park MY, Ahn KY

Botulinum toxin type A (BoNT-A), onabotulinumtoxinA (Botox) was approved by the United States Food and Drug Administration for temporary improvement of glabellar lines in patients 65 years and younger in...
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Alternative Methods for Testing Botulinum Toxin: Current Status and Future Perspectives

Nepal MR, Jeong TC

Botulinum toxins are neurotoxic modular proteins composed of a heavy chain and a light chain connected by a disulfide bond and are produced by Clostridium botulinum. Although lethally toxic, botulinum...
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Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm

Kim YB, Choi JM, Chang YJ, Choi HR, In J, Yang HS

Background: In this study, we used an ex-vivo model to investigate the recovery pattern of both the train-of-four (TOF) ratio and first twitch tension of TOF (T1), and determined their...
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A Novel Immunomodulatory Mechanism Dependent on Acetylcholine Secreted by Human Bone Marrow-derived Mesenchymal Stem Cells

Yi TG, Cho YK, Lee HJ, Kim J, Jeon MS, Ham DS, Kim WC, Song SU

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) are used to treat autoimmune or inflammatory diseases. Our aim was to determine the immunomodulatory mechanisms elicited by MSCs during inflammation. METHODS AND RESULTS:...
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Association between Ischemic Electrocardiographic Changes during Acetylcholine Provocation Test and Long-Term Clinical Outcomes in Patients with Vasospastic Angina

Im SI, Rha SW, Choi BG, Na JO, Choi CU, Lim HE, Kim JW, Kim EJ, Park CG, Seo HS

OBJECTIVES: Intracoronary injection of acetylcholine (Ach) has been shown to induce significant coronary artery spasm (CAS) in patients with vasospastic angina. Clinical significance and angiographic characteristics of patients with ischemic...
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Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala

Lee S, Kim JH

The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning....
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Impact of Insulin Resistance on Acetylcholine-Induced Coronary Artery Spasm in Non-Diabetic Patients

Kang KW, Choi BG, Rha SW

PURPOSE: Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association...
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GABA-enriched fermented Laminaria japonica improves cognitive impairment and neuroplasticity in scopolamine- and ethanol-induced dementia model mice

Reid SN, Ryu JK, Kim Y, Jeon BH

BACKGROUND/OBJECTIVES: Fermented Laminaria japonica (FL), a type sea tangle used as a functional food ingredient, has been reported to possess cognitive improving properties that may aid in the treatment of...
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Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model

Han SH, Kim SJ, Yun YW, Nam SY, Lee HJ, Lee BJ

This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJG0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male...
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Methidathion Poisoning

Kim KH, Kim SH, Her C

Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution...
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Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents

Kim YB, Sung TY, Yang HS

Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric...
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Influence of Repeated Senna Laxative Use on Skin Barrier Function in Mice

Yokoyama S, Hiramoto K, Yamate Y, Ooi K

BACKGROUND: Senna, one of the major stimulant laxatives, is widely used for treating constipation. Chronic senna use has been reported to be associated with colonic disorders such as melanosis coli...
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