- Suppression of ARID1A associated with decreased CD8 T cells improves cell survival of ovarian clear cell carcinoma
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Jung US, Min KW, Kim DH, Kwon MJ, Park H, Jang HS
- KMID: 2526293
- J Gynecol Oncol.
- 2021 Jan;32(1):e3.
- doi: 10.3802/jgo.2021.32.e3
Objective: AT-rich interactive domain 1A (ARID1A) plays an important role as a tumor suppressor gene in ovarian clear cell carcinoma (OCCC), but the clinical application of ARID1A remains unclear. The... -
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- Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
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Yoon KA, Woo SM, Kim YH, Kong SY, Lee MK, Han SS, Kim TH, Lee WJ, Park SJ
- KMID: 2464315
- Gut Liver.
- 2019 Nov;13(6):683-689.
- doi: 10.5009/gnl18355
BACKGROUND/AIMS: Pancreatic ductal adenocarcinoma (PDA) is associated with an extremely poor prognosis. This study assessed the genetic diversity among patients with PDA and compared their mutational profiles before and after... -
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- Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel
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Choi S, Go JH, Kim EK, Lee H, Lee WM, Cho CS, Han K
- KMID: 2353658
- Genomics Inform.
- 2016 Sep;14(3):78-84.
- doi: 10.5808/GI.2016.14.3.78
Extranodal natural killer (NK)/T-cell lymphoma, nasal type (NKTCL), is a malignant disorder of cytotoxic lymphocytes of NK or T cells. It is an aggressive neoplasm with a very poor prognosis.... -
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- Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives
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Mabuchi S, Sugiyama T, Kimura T
- KMID: 2363325
- J Gynecol Oncol.
- 2016 May;27(3):e31.
- doi: 10.3802/jgo.2016.27.e31
Clear cell carcinoma (CCC) of the ovary is known to show poorer sensitivity to chemotherapeutic agents and to be associated with a worse prognosis than the more common serous adenocarcinoma... -
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- Loss of Tumor Suppressor ARID1A Protein Expression Correlates with Poor Prognosis in Patients with Primary Breast Cancer
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Cho HD, Lee JE, Jung HY, Oh MH, Lee JH, Jang SH, Kim KJ, Han SW, Kim SY, Kim HJ, Bae SB, Lee HJ
- KMID: 2176282
- J Breast Cancer.
- 2015 Dec;18(4):339-346.
- doi: 10.4048/jbc.2015.18.4.339
PURPOSE: Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer. The purpose of this study was... -
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- Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features
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Kim KJ, Jung HY, Oh MH, Cho H, Lee JH, Lee HJ, Jang SH, Lee MS
- KMID: 2372206
- J Gastric Cancer.
- 2015 Sep;15(3):201-208.
- doi: 10.5230/jgc.2015.15.3.201
PURPOSE: The AT-rich interactive domain 1A (ARID1A) gene encodes BRG1-associated factor 250a, a component of the SWItch/Sucrose NonFermentable chromatin remodeling complex, which is considered a tumor suppressor in many tumors.... -
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- Decreased ARID1A expression is correlated with chemoresistance in epithelial ovarian cancer
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Yokoyama Y, Matsushita Y, Shigeto T, Futagami M, Mizunuma H
- KMID: 1811189
- J Gynecol Oncol.
- 2014 Jan;25(1):58-63.
- doi: 10.3802/jgo.2014.25.1.58
OBJECTIVE: Loss of ARID1A is related to oncogenic transformation of ovarian clear cell adenocarcinoma. The present study was conducted in epithelial ovarian cancer of all tissue types to investigate whether... -
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- The roles of ARID1A in gynecologic cancer
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Mao TL, Shih IM
- KMID: 2177880
- J Gynecol Oncol.
- 2013 Oct;24(4):376-381.
- doi: 10.3802/jgo.2013.24.4.376
One of the exciting findings in recent cancer genome studies is the discovery of somatic mutations in several chromatin remodeling genes. These studies not only illuminate the emerging roles of... -
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