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Roles of Tumor Markers in Diagnosis and Treatment of Hepatocellular Carcinoma

Chang Y, Jang JY

There are a wide variety of tumor markers for hepatocellular carcinoma (HCC). Studies are ongoing regarding the roles of tumor markers in screening, diagnosis, treatment, and prognostic prediction of HCC....
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Primary Pelvic Peritoneal Yolk Sac Tumor in the Post-Pubertal Female: a Case Report with Literature Review

Kim M, Lee EJ, Hwang J, Hong SS, Chang YW, Oh E, Nam BD, Choi I, Kim JS

Yolk sac tumors are rare malignant germ cell neoplasms that usually arise from the gonads. Extragonadal yolk sac tumors (EGYSTs) frequently occur in the mediastinum in post-pubertal females. EGYSTs in...
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Analytical Performance of New ARCHITECT AFP Assay: Comparison with the Current Assay

Woo KS, An GD, Lim HH, Han JY

Alpha-fetoprotein (AFP) is frequently used for hepatocellular carcinoma (HCC) diagnosis and surveillance. Although the current ARCHITECT AFP (List number 7K67) assay range is 0–350 ng/mL, all samples with test results...
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Recent Update in Hepatoblastoma

Park M

Hepatoblastoma, the most common primary liver tumor of early childhood, is a rare neoplasm, accounting for 0.8-2.0% of all pediatric cancers. The etiology is unknown. The most common method of...
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Impact of immunosuppressant therapy on early recurrence of hepatocellular carcinoma after liver transplantation

Lee JY, Kim YH, Yi NJ, Kim HS, Lee HS, Lee BK, Kim H, Choi YR, Hong G, Lee KW, Suh KS

BACKGROUND/AIMS: The most commonly used immunosuppressant therapy after liver transplantation (LT) is a combination of tacrolimus and steroid. Basiliximab induction has recently been introduced; however, the most appropriate immunosuppression for...
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In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression

Kim KI, Lee YJ, Lee TS, Song I, Cheon GJ, Lim SM, Chung JK, Kang JH

  • KMID: 1427701
  • Nucl Med Mol Imaging.
  • 2013 Mar;47(1):1-8.
PURPOSE: This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human...
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Evaluation of the UniCel(TM) DxI 800 Immunoassay Analyzer in Measuring Five Tumor Markers

Park Y, Park Y, Park J, Kim HS

PURPOSE: Tumor marker concentrations in a given specimen measured by different analyzers vary according to assay methods, epitopes for antibodies used, and reagent specificities. Although great effort in quality assessment...
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Hepatoid Adenocarcinoma of the Stomach Misconceived as a Primary Liver Tumor

Park DE, Lee HB, Chae KM

Hepatoid adenocarcinomas of the stomach are gastric carcinomas with both adenocarcinomatous and hepatocellular differentiations. The tumor was characterized by high serum alpha-fetoprotein (AFP) levels. A 73-year-old male patient was admitted...
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Gastric Adenocarcinoma with Coexistent Hepatoid Adenocarcinoma and Neuroendocrine Carcinoma: A Case Report

Kim A, Kim SW, Song SK, Bae YK

This report represents a very rare case of a gastric adenocarcinoma that was coexistent with hepatoid adenocarcinoma and neuroendocrine carcinoma. A 77-year-old man was admitted to our hospital due to...
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The Prognostic Significance of the Preoperative Serum CEA, CA19-9 and AFP Levels in Gastric Cancer Patients

Na KY, Chang YS, Kim YH, Joo SH, Lee SH

  • KMID: 2211238
  • J Korean Surg Soc.
  • 2008 Nov;75(5):302-306.
PURPOSE: No tumor-specific markers for gastric cancer are currently known, although various tumor markers have been utilized. CEA, CA19-9 and AFP are the most commonly used tumor markers for gastric...
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Radioiodine Therapy of Liver Cancer Cell Following Tissue Specific Sodium Iodide Symporter Gene Transfer and Assessment of Therapeutic Efficacy with Optical Imaging

Jang BK, Lee YL, Lee YJ, Ahn SJ, Ryu MJ, Yoon SM, Lee SW, Yoo J, Cho JY, Lee J, Ahn BC

  • KMID: 2051951
  • Nucl Med Mol Imaging.
  • 2008 Oct;42(5):383-393.
PURPOSE: Cancer specific killing can be achieved by therapeutic gene activated by cancer specific promotor. Expression of sodium iodide symporter (NIS) gene causes transportation and concentration ofiodide into the cell,...
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The Influence of Alpha-fetoprotein on Natural Suppressor Cell Activity and Ehrlich Carcinoma Growth

Belyaev NN, Bogdanov A, Savvulidi , Krasnoshtanov VK, Tleulieva , Alipov GK, Sekine I, Bae JS, Lee JB, Min YK, Yang HM

The influence of alpha-fetoprotein (AFP) on the bone marrow (BM) natural suppressor (NS) cells of intact Ehrlich carcinoma -bearing CBA mice was studied. Bone marrow NS cells were fractionated into...
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Establishment of Reference Intervals of Tumor Markers in Korean Adults

Woo HY, Kim YJ, Park H

BACKGROUND: The sensitivity and specificity of tumor markers for detecting cancer could be significantly changed by the reference intervals of tumor markers. We established reference intervals of tumor markers in...
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A Case of Positive Amniotic AFP, Acetylcholinesterase in a Normal Pregnancy after Undergoing Periodic Targeted Ultrasonographic Evaluation

Ri PH, Sun JH, Cha DH, Park SW, Chung CJ

  • KMID: 2072166
  • Korean J Perinatol.
  • 2006 Dec;17(4):413-418.
Neural tube defects are reported one of the important congenital malformation in the world, with an incidence of 1.4 to 2 per 1000 pregnancies. Maternal serum AFP at the second...
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Midtrimester triple test in IVF/ICSI twin pregnancies

Kim HO, Song IO, Cha SW, Han JY, Shin JS, Kang IS, Koong MK

  • KMID: 2272945
  • Korean J Obstet Gynecol.
  • 2006 Nov;49(11):2341-2346.
OBJECTIVE: To compare the midtrimester triple marker levels for down syndrome screening between natural and IVF twin pregnancies and to evaluate the difference triple marker in IVF twin pregnancies according...
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Acute Exacerbation of Hepatitis in Liver Cirrhosis with Very High Levels of alpha-Fetoprotein But No Occurrence of Hepatocellular Carcinoma

Bae JS, Park SJ, Park KB, Paik SY, Ryu JK, Choi CK, Hwang TJ

Aminotransferase levels do not always increase during acute hepatitis or during an acute flare-up of chronic hepatitis. Persistently increased levels of serum alpha-Fetoprotein in an adult with liver disease suggest...
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Determination of Reference Level for Triple Marker in Korean Population

Cho HJ, Lee SY, Kim JW

  • KMID: 1895342
  • J Lab Med Qual Assur.
  • 2004 Jun;26(1):185-192.
BACKGROUND: The triple marker test with maternal serum during 15~20 weeks gestation is a useful prenatal screening technique. However established reference level is determined for Caucasians and there has not...
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An Evaluation of Prenatal Triple Marker Screening

Cha YJ, Yang JS, Chae SL, Park AJ

  • KMID: 2239589
  • Korean J Lab Med.
  • 2003 Jun;23(3):199-204.
BACKGROUND: Maternal serum triple marker screening has become standard in prenatal care to help identify women at risk for neural tube defects (NTDs), trisomy 21 (Down syndrome) and trisomy 18...
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An Analysis of Cost-Effective Screening Interval for HCC in Korean Hepatitis B Virus Carriers

Roh JH, Lee SJ, Choi JY, Lee SN, Shin YK

  • KMID: 2294872
  • J Korean Acad Fam Med.
  • 2002 Nov;23(11):1340-1347.
BACKGROUND: The purpose of this study was to evaluate the cost-effectiveness of screening tests (AFP and US) for early detection of primary hepatocellular carcinoma (HCC) and its optimal screening interval...
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Prevention of liver cancer: basic and clinical aspects

Moriwaki H

  • KMID: 755202
  • Exp Mol Med.
  • 2002 Nov;34(5):319-325.
Cancer prevention is a challenging project both in the basic and clinical medicine. In particular, prevention of liver cancer is the most urgent task in countries where the incidence of...
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