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Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting

Kim MS, Lee JR, Choi EM, Kim EH, Choi SH

PURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with...
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Palonosetron versus granisetron in combination with aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with gynecologic cancer

Fujiwara S, Terai Y, Tsunetoh S, Sasaki H, Kanemura M, Ohmichi M

OBJECTIVE: There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC). We evaluated the antiemetic efficacy of a combination of 5-HT3...
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Effects of Palonosetron, a 5-HT3 Receptor Antagonist, on Mechanical Allodynia in a Rat Model of Postoperative Pain

Jung KT, Yoon MH, Lee HY, Yu BY, Kim DK, Lim KJ

BACKGROUND: 5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or...
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Effects of Ramosetron on Gastrointestinal Transit of Guinea Pig

Park YM, Lee YJ, Lee YH, Kim TI, Park H

  • KMID: 2325969
  • J Neurogastroenterol Motil.
  • 2013 Jan;19(1):36-41.
BACKGROUND/AIMS: A selective 5-hydroxytryptamine (5-HT) type 3 receptor antagonist, ramosetron, inhibits stress-induced abnormal defecation in animals and is currently used as a therapeutic drug for irritable bowel syndrome with diarrhea....
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Open-label, Randomized Comparison of the Efficacy of Intravenous Dolasetron Mesylate and Ondansetron in the Prevention of Acute and Delayed Cisplatin-induced Emesis in Cancer Patients

Kim JS, Baek JY, Park SR, Choi IS, Kim SI, Kim DW, Im SA, Kim TY, Heo DS, Bang YJ, Kim NK

  • KMID: 2166128
  • Cancer Res Treat.
  • 2004 Dec;36(6):372-376.
PURPOSE: The aim of this study is to compare the antiemetic efficacy and tolerability of intravenous dolasetron mesylate and ondansetron in the prevention of acute and delayed emesis. MATERIAL AND...
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Postoperative Suppression of Nausea and Vomiting by Preoperative Administ ration of 5-HT3 Receptor Antagonist [Granisetron]in Strabismus Surgery Under Topical Anesthesia

Park SC, La TY

  • KMID: 2336900
  • J Korean Ophthalmol Soc.
  • 2000 Mar;41(3):585-591.
Traction of the extraocular muscles during strabismus surgery could cause nausea and vomiting in postoperative period. Although the extent of these symptoms would vary in wide range, sometimes they are...
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Psychosis in Parkinson

Koh SB, Park KW, Lee DH

  • KMID: 1944956
  • J Korean Soc Biol Psychiatry.
  • 1997 Jun;4(1):132-135.
Current treatment strategies for levodopa-induced psychosis in advanced Parkinson's disease have had limited success. Reduction or discontinuation of levodopa and coadministration with dopamine-blocking neuroleptics may attenuate the psychotic symptoms, but...
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