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¹²³I-Meta-iodobenzylguanidine Sympathetic Imaging: Standardization and Application to Neurological Diseases

Nakajima K, Yamada M

¹²³I-meta-iodobenzylguanidine (MIBG) has become widely applied in Japan since its introduction to clinical cardiology and neurology practice in the 1990s. Neurological studies found decreased cardiac uptake of ¹²³I-MIBG in Lewy-body...
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Paraganglioma Presenting as Dilated Cardiomyopathy with Cardiogenic Shock and Sepsis

Lee CW, Hong SP, Lee JH, Kim JW, Lee HC, Kwon HH

Rarely, a paraganglioma can lead to disastrous cardiac complications such as heart failure, cardiomyopathy, or myocardial infarction and inflammatory complications such as sepsis. We describe a 41-year-old man who developed...
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A Case of Paroxysmal Pheochromocytoma with Normal Catecholamine Levels

Yu JR, Chin HJ, Kim M, Jeong WS, Lee SA, Lee DH, Koh G

  • KMID: 2264572
  • Korean J Med.
  • 2012 Oct;83(4):503-509.
A 53-year-old woman had a 1.7 cm left adrenal mass on an abdominal computed tomography (CT) scan. She presented with paroxysmal headache, palpitation, sweating, and hypertension. The patient was highly...
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A case of metastatic malignant pheochromocytoma response to high dose 131I-MIBG treatment after surgery

Lee SW, Kim JG, Ha SW, Ahn BC, Lee JT, Kim BW, Kim BW

  • KMID: 1927327
  • Korean J Med.
  • 2004 Nov;67(Suppl 3):S871-S875.
Approximately 10% of pheochromocytomas are malignant and its major criteria are tumor invasion of capsular blood vessel as well as metastatic invasion of other tissues. It is general rule that...
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Nuclear Theranostics in Turkey

Bozkurt MF

Nuclear theranostics functions as a bridge which connects targeted diagnosis to targeted therapy, just like Turkey functions as a geographical bridge which connects Asia to Europe. This unique geographical site...
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A Case Report of Recurrent Malignant Paraganglioma with Lung and Spine Metastasis that Occurred Sixteen Years after Primary Tumor Excision

Moon ES, Min HS, Jung CH, Choi JH, Kim JS, Yoo HJ, Choi SY

Paragangliomas are rare tumors that arise from the extra-adrenal chromaffin cells, and malignancy is defined by the presence of metastases to sites that normally lack chromaffin tissue. The main therapeutic...
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Clinical Implications of Cardiac-MIBG SPECT in the Differentiation of Parkinsonian Syndromes

Shin DH, Lee PH, Bang OY, Joo IS, Huh K

BACKGROUND AND PURPOSE: 123I cardiac meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used to estimate myocardial sympathetic nerve function. We investigate whether cardiac-MIBG SPECT is clinically applicable in the...
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Pheochromocytoma in Children

Ha TS, Park JH, Ha IS, Cheong HI, Choi Y, Moon HR, Park GW

  • KMID: 1879420
  • J Korean Pediatr Soc.
  • 1994 Jul;37(7):961-968.
We Reviewed 10 hypertensive children with pheochromocytoma retrospectively and the following results were obtained. 1) Out of 10 patients, 7 were male and 3 female. Age ranged from 5.5 years...
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Olfactory Function and Its Correlation with Cardiac 123I-MIBG in Patients with Parkinson's Disease and Multiple System Atrophy

Yeo SH, Shin DH, Kim HJ, Lee PH

  • KMID: 2185247
  • J Korean Neurol Assoc.
  • 2007 Feb;25(1):38-43.
BACKGROUND: Olfactory dysfunction is common in patients with Parkinsons disease (PD) and may precede the development of parkinsonian motor symptoms. Cardiac sympathetic denervation, which can be visualized by a cardiac...
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Review of Radionuclide Treatment for Neuroendocrine Tumors

Jeong HJ

  • KMID: 2313018
  • Nucl Med Mol Imaging.
  • 2006 Apr;40(2):90-95.
Neuroendocrine tumors (NETs) consist of a heterogeneous group of tumors that are able to uptake neuroamine and/or specific receptors, such as somatostatin receptors, which can play important roles of the...
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Pheochromocytoma Developed in a Boy with Multiple Endocrine Neoplasia Type 2A Confirmed by the RET Proto-Oncogene Mutation

Park SY, Jin MJ, Choi EM, Kang SJ, Choi JH, Shim YJ, Kim HS, Jung EY, Lee HJ, Choi MS, Kim HW

A 9-year-old boy presented with increased sweating and abdominal pain. His mother and uncle had been diagnosed with bilateral pheochromocytoma and medullary thyroid carcinoma. Magnetic resonance imaging of the boy's...
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A Significant Discrepancy of Uptake between I-131 MIBG and F-18 FDG in a Patient With Malignant Paraganglioma

Kim JS, Kim HK, Choi KY, Park HK, Kim ES, Kim YK, Kim S, Kim YJ, Lee HJ

  • KMID: 1518948
  • Nucl Med Mol Imaging.
  • 2007 Jun;41(3):247-251.
A 38-year-old man who was diagnosed with malignant paraganglioma underwent computed tomography (CT) and I-131 metaiodobenzylguanidine (MIBG) san. CT showed extensive lymph node enlargement in right iliac area and retroperitoneum...
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A Case Of Adrenal Ganglioneuroma Secreting Catecholamines

Kang HC, Kang HS, Kim JS, Kang SH, Kim KM, Chung MY, Lee JH

  • KMID: 2081102
  • Korean J Med.
  • 2005 Jan;68(1):111-115.
Ganglioneuromas is a rare benign neoplasm that originates from the sympathetic ganglia and the adrenal medulla. It belongs to the group of neurogenic tumors, which also include ganglioneuroblastoma and neuroblastoma....
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Diagnostic Efficacy of Biochemical Studies and MIBG Scan in Pheochromocytoma

Park H, Kim JG, Hong B, Kim CS, Park T, Ahn HJ

  • KMID: 1914282
  • Korean J Urol.
  • 1997 Dec;38(12):1291-1295.
We evaluated the role of clinical symptoms, biochemical studies and metaiodobenzylguanidine (MIBG) scan in the diagnosis of pheochromocytoma. From August 1991 to June 1997, 42 patients with complaints of hypertension...
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Current Consensus on I-131 MIBG Therapy

Kayano D, Kinuya S

Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter norepinephrine and specifically targets neuroendocrine cells including some neuroendocrine tumors. Iodine-131 (I-131)-labeled MIBG (I-131 MIBG) therapy for neuroendocrine tumors has been performed...
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Two cases of sudden cardiac death syndrome associated with right bundle branch block and ST segment elevation

Park SS, Nam GB, Choi KJ, Song JK, Kim JJ, Park SJ, Park JH, Kim YH

In 1992, Brugada described clinical features of patients with aborted sudden cardiac death who showed no demonstrable heart disease and a peculiar ECG pattern consisting of right bundle branch block...
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Clinical Application of I-123 MIBG Cardiac Imaging

Kang DY

  • KMID: 1516858
  • Korean J Nucl Med.
  • 2004 Oct;38(5):331-337.
Cardiac neurotransmission imaging allows in vivo assessment of presynaptic reuptake, neurotransmitter storage and postsynaptic receptors. Among the various neurotransmitter, I-123 MIBG is most available and relatively well- established. Metaiodobenzylguanidine (MIBG)...
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A Clinical Analysis of Pheochromocytoma

Kim JC, Yoon JH, Jegal YJ

  • KMID: 1939735
  • J Korean Surg Soc.
  • 1997 May;52(5):662-670.
Pheochromocytoma manifesting hypertensive episodes, is a catecholamine-secreting neoplasm, that arises from the chromaffin cells This clinical study was performed on 12 cases of pheocromocytoma treated surgically at the Department of...
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The Efficacy of MIBG Scan as a Diagnostic and Docalization Test for Pheochromocytoma

Park CK, Kim KW, Kim DH, Kim JH, Kang JG, Kim SW, Cho YM, Park DJ, Shin CS, Park KS, Cho BY, Lee HK, Kim SY

BACKGROUND: Computed tomography(CT) is currently considered as the initial imaging procedure of choice for the localization of pheochromocytomas in most of the cases. 131I-or 123I-Metaiodobenzylguanidine scintigraphy(MIBG scan) was proven to...
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Efficacy of I-123/I-131 Metaiodobenzylguanidine Scan as A Single Initial Diagnostic Modality in Pheochromocytoma: Comparison with Biochemical Test and Anatomic Imaging

Moon EH, Lim ST, Jeong YJ, Kim DW, Jeong HJ, Sohn MH

  • KMID: 1841148
  • Nucl Med Mol Imaging.
  • 2009 Oct;43(5):436-442.
PURPOSE: We underwent this study to evaluate the diagnostic potential of I-123/I-131 metaiodobenzylguanidine (MIBG) scintigraphy alone in the initial diagnosis of pheochromocytoma, compared with biochemical test and anatomic imaging. MATERIALS &...
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