- Effect of Vitamin A and E on the Interaction Between 2-Acetylaminofluorene and Rat Liver DNA in Vivo
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Hong YS
- KMID: 1965651
- Ewha Med J.
- 1985 Jun;8(2):99-109.
- doi: 10.12771/emj.1985.8.2.99
Binding of the hepatocarcinogen 2-acetylaminofluorene(AAF) to the DNA of rat liver homogenates was examined in vivo. Animals fed low and high concentrations vitamin A and E for 28 days and... -
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- A Study for The Effects of UV exposure and UV Exposure After Being Applied by Sunscreens on Hepatic Microsomal Cytochrome Enzyme System and Vitamin D in Newborn Rats
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Ryu KO, Kook HI, Seong NE
- KMID: 2146622
- Korean J Dermatol.
- 1986 Apr;24(2):205-212.
We observe changes of activation of hepatic microsomal cytochrome p-450, changes of formation of riug-and N-hydroxylation of 2-acetylaminofluorene, and changes of vitamin D, in the liver which exposed to UV... -
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- Effect of Thiamine Deficiency on Drug Hydroxylation and Level of Cytochrome P-450 in the Rats
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Kim BH, Hong YS, Sung NE
- KMID: 1969656
- Ewha Med J.
- 1979 Dec;2(4):195-199.
- doi: 10.12771/emj.1979.2.4.195
Our studies are concerned with cytochrome P-450 content and 2-acetylaminofluorene N-and ring-hydroxylation by thiamine deficient rat liver microsomes. Incubation medium contained 100mM HEPES buffer pH 7.8, 2mM NADPH, 100mM KF,... -
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- Effect of L-Ascorbic Acid and DL-alpha-Tocopherol on the Activation and Binding of 2-Acetylaminofluorene to Rat Liver Nuclear Macromolecules in Vivo
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Hong YS
- KMID: 2170804
- Ewha Med J.
- 1986 Dec;9(4):219-227.
- doi: 10.12771/emj.1986.9.4.219
Male Sprangue-Dawley rats which had been administered either ascorbic acid or DL-alpha-tocopherol for 4 weeks were injected intraperitoneally with a single dose of(9-14C)-2-acetylaminofluorens(AAF) 3.5hr before sacrifice. The activation and binding... -
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- Effects of Chronic Alcohol Feeding on the Lipid Contents in the Rat Liver and the Hepatic Microsomal 2-Acetylaminofluorene(1-AAF) Hydroxylation in Vitro
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Choi KJ
- KMID: 1967728
- Ewha Med J.
- 1983 Mar;6(1):35-46.
- doi: 10.12771/emj.1983.6.1.35
It is now well established that ethanol excerts different effect on hepatic cellular metabolism, depending mainly on the duration of its intake. And induction of quantitative and qualitative alterations in... -
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- Transforming growth factor-beta1 protein, proliferation and apoptosis of oval cells in acetylaminofluorene-induced rat liver regeneration
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Park DY, Suh KS
- KMID: 646021
- J Korean Med Sci.
- 1999 Oct;14(5):531-538.
- doi: 10.3346/jkms.1999.14.5.531
Administering of 2-acetylaminofluorene (2-AAF) before a two-thirds partial hepatectomy (PHx) results in suppression of hepatocyte proliferation and stimulation of oval cell proliferation. The objectives of this study was to examine... -
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- The Effects of Vitamin B Complexes on AAF Hydroxylation by Rat Liver Microsomal Cytochrome P-450
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Hong YS, Kim BH, Sung NE
- KMID: 1969574
- Ewha Med J.
- 1980 Sep;3(3):113-118.
- doi: 10.12771/emj.1980.3.3.113
The effects of vitamin B complexes on both ring and N-hydroxylation of 2-ace-tylaminofluorene by rat hepatic microsomal fraction were studied. In the presence of thiamine-Hcl during incubation, the total hydroxy-AAF was... -
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- The Effects of Phenobarbital or Cholic Acid on Hepatic Microsomal Cytochrome P450 and Hydroxylation of 2-AAF in Cholestatic Rats
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Kim BH, Hong YS, Sung NE
- KMID: 1969538
- Ewha Med J.
- 1981 Sep;4(3):83-89.
- doi: 10.12771/emj.1981.4.3.83
In cholestatic rats, effects of phenobarbital or cholic acid on hepatic microsomal cytochrome p-450 and b5 were investigated. The total contents of both cytochrome p-450 and cytochrome b5 were decreased... -
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- Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis
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Kim HS, Kim HS, Choi H
- KMID: 2139197
- Nutr Res Pract.
- 2008 Dec;2(4):234-239.
- doi: 10.4162/nrp.2008.2.4.234
The purpose of this study was to investigate the effects of green tea ingestion on hepatocarcinogenesis before and after its initiation. Male Sprague-Dawley rats were fed an AIN76A diet with... -
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- Sequential Changes of Proliferative Fraction of Enzyme Altered Fdegrees Ci in Experimental Rat Hepatdegrees Carcinogenesis
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Kim WH, Yoo YS, Kim YI, Lee MS, Lee MJ, Jang JJ
- KMID: 2175021
- J Korean Cancer Assoc.
- 2000 Jun;32(3):563-570.
PURPOSE: The proliferative activity of cells in enzyme altered fdegrees Ci of the rat hepatoma model was measured by double immunohistdegrees Chemical staining methods using anti-bromodeoxyuridine (BrdU) and anti-glutathione S transferase of... -
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- Proliferation of Hepatic Oval Cells via Cyclooxygenase-2 and Extracellular Matrix Protein Signaling during Liver Regeneration Following 2-AAF/Partial Hepatectomy in Rats
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Bae SH, Oh SH, Yoon SK, Park JA, Kim GD, Hur W, Choi JY, Oh IH, Yoon KH
- KMID: 2284221
- Gut Liver.
- 2011 Sep;5(3):367-376.
BACKGROUND/AIMS: In the 2-acetylaminofluorene (2-AAF)/70% partial hepatectomy (PHx) model, the mechanism underlying the differentiation of activated hepatic oval cells (HOCs) into hepatocytes and bile ductile cells is unclear. We investigated... -
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- Characterization of Tumor Specific Antigens on the Plasma Membrane Surface of Rat Hepatomas lnduced by 3'-Me DAB and ldentification of the Common Tumor Specific Antigens from Rat Hepatomas lnduced by Different Chemical Hepatocarcinogens
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Kim YS, Hahm KS, Kim KS, Lee NJ
- KMID: 693108
- Yonsei Med J.
- 1988 Mar;29(1):17-28.
- doi: 10.3349/ymj.1988.29.1.17
Three different chemical carcinogens, 2-acetylaminofluorene (AAF), diethylnitrosamine(DENA), and 3'-methyl-4dimethylaminoazobenzene (3'-Me DAB) were used to induce hepatomas in rats. Plasma membrane surface proteins of normal rat liver cells and rat hepatomas... -
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- Factors Influencing the Pathogenicity of Entamoeba Histolytica
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Soh CT
- KMID: 693106
- Yonsei Med J.
- 1988 Mar;29(1):1-10.
- doi: 10.3349/ymj.1988.29.1.1
In summarizing the results of the experimental studies up to the present, it is conjectured that the pathogenicity of Entamoeba histolytica or establishment of amoebiasis is not unique but differs... -
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