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Structural Insights for β-Lactam Antibiotics

Kim D, Kim S, Kwon Y, Kim Y, Park H, Kwak K, Lee H, Lee JH, Jang KM, Kim D, Lee SH, Kang LW

Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds...
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Myths and Misconceptions around Antibiotic Resistance: Time to Get Rid of Them

Amábile-Cuevas CF

The antibiotic resistance arena is fraught with myths and misconceptions, leading to wrong strategies to combat it. It is crucial to identify them, discuss them in light of current evidence,...
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Risk factors associated with development of coinfection in critically Ill patients with COVID-19

Orsini EM, Sacha GL, Han X, Wang X, Duggal A, Rajendram P

Background: At outset of the coronavirus disease 2019 (COVID-19) pandemic, the significance of bacterial and fungal coinfections in individuals with COVID-19 was unknown. Initial reports indicated that the prevalence of...
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Prevalence of Empiric Antibacterial Therapy, Community-Acquired Bacterial Superinfection, and Antibiotic-Associated Adverse Reactions among Patients with COVID-19 Pneumonia Admitted in Makati Medical Center from March 2020 to March 2021

Galang – De Leon WAM, Buensalido JAL

Background: Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus which was first discovered in Wuhan, China. Being a viral illness, antibacterial agents theoretically have no role in patients...
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Isolation, Characterization and in vitro Evaluation of Specific Bacteriophages Targeting Extensive Drug Resistance Strains of Pseudomonas aeruginosa Isolated from Septic Burn Wounds

Amin Marashi SM, Nikkhahi F, Hamedi D, Shahbazi G

Background: Antibiotic resistant bacteria and various infections caused by them especially extensive drug resistance (XDR) strains and worrying statistics of mortality due to these strains and also the lack of...
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Treatment of pigs with enrofloxacin via different oral dosage forms – environmental contaminations and resistance development of Escherichia coli

Janssen P, Barton G, Kietzmann M, Meißner J

Background: Antibacterial agents play important roles in the treatment of bacterial infections. However, the development of antimicrobial resistance (AMR) and carry-over of substances into the environment are several problems arising...
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Clinical Features of Group B Streptococcus Colonization in Vagina During Late Pregnancy at a Primary Maternity Hospital

Oh S, Park JS

Purpose: The aim of this study was to assess the epidemiologic and clinical features of maternal Group B Streptococcus (GBS) colonization in vagina during their third trimester. Methods: This study included...
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The change of antibiotic susceptibility in febrile urinary tract infection in childhood and adolescence during the last decade

Choi U, Kim E, Lyu DH, Kim KS, Park BH, Chung H, Han CH, Bae S

Purpose: The purpose of this study was to clarify the pattern of antibiotic resistance in pediatric urinary tract infections (UTIs). Materials and Methods: We analyzed the data of entire urine culture...
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A Direct Rapid Phenotypic Antimicrobial Susceptibility Test Enables Early Selection of Optimal Antibiotics to Treat Bacteremia in COVID-19 Patients

Park DH, Chang E, Kang CK, Choe PG, Kim NJ, Kim TS, Park WB, Oh Md

Background: Co-infection with bacteria and severe acute respiratory syndrome coronavirus 2 may result in greater use of healthcare resources and a poor prognosis. Therefore, early selection and use of optimal...
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Reduced Susceptibility to Biocides among Enterococci from Clinical and Non-Clinical Sources

Sobhanipoor MH, Ahmadrajabi R, Hosseini Nave H, Saffari F

Background: Wide use of biocidal agents such as benzalkonium chloride (BCC) and chlorhexidine digluconate (CHX) in hospitals and non-hospital environments, has raised concerns over the emergence of non-susceptible strains. Efflux...
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Recurrent Meningitis Caused by β-Lactamase-Positive Amoxicillin/ Clavulanate-Resistant Non-Typeable Haemophilus influenzae in a Child with an Inner Ear Malformation: A Case Report

Shin H, Kim G, Han SB, Jeong DC, Kang JH

Infections with Haemophilus influenzae type b have been decreasing due to widespread use of conjugate vaccines thereto, and there has been an increasing trend in the relative proportion of invasive...
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Antimicrobial Management of Complicated Skin and Soft Tissue Infections in an Era of Emerging Multi-Drug Resistance: Perspectives from 5 Gulf Countries

Alfouzan W, Al-Balushi Z, Al-Maslamani M, Al-Rashed A, Al-Sabah S, Al-Salman J, Baguneid M, Khamis F, Habashy N, Kurdi A, Eckmann C

The number of complicated skin and soft tissue infections (cSSTIs) in the Arabian Gulf region has risen in recent years, particularly those caused by multi-drug resistant (MDR) pathogens. The high...
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Helicobacter pylori Treatment Strategies in Singapore

Ang TL, Ang D

The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over...
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Do we need topical antibiotics for simple excision or the dressing after a skin wound?

Kim IH

We often use topical antibiotics for simple excisions or the skin after minor wounds. This is a long-standing practice to minimize scarring by preventing wound or surgical site infection to...
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Trend of Antibiotic Susceptibility of Haemophilus influenzae Isolated from Children, 2014–2019

Lee E, Park S, Kim M, Lee J

Purpose: We investigated the trend of antibiotic susceptibility of Haemophilus influenzae over 5 consecutive years. Methods: We analyzed the antibiotic susceptibility of H. influenzae isolated from children aged
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Immunological Profile and Bacterial Drug Resistance in Pregnant Women: A Cross Sectional Study

Ngalani OJ, Marbou WJ, Mbaveng AT, Kuete V

Objectives: This study aimed to investigate the immunological and bacterial profiles in pregnant women of Bafang-Cameroon. Methods: Stool and midstream urine were cultured using specific culture media. The disk diffusion method...
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Characterization of Antimicrobial Susceptibility, Extended-Spectrum β-Lactamase Genes and Phylogenetic Groups of Enteropathogenic Escherichia coli Isolated from Patients with Diarrhea

Jafari E, Mostaan S, Bouzari S

Objectives: Infectious diarrhea is one of the most common causes of pediatric death worldwide and enteropathogenic Escherichia coli (EPEC) is one of the main causes. There are 2 subgroups of...
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The Impact of Antibiotic-Loaded Bone Cement on Antibiotic Resistance in Periprosthetic Knee Infections

Schmitt DR, Killen C, Murphy M, Perry M, Romano J, Brown N

Background: Antibiotic-loaded bone cement (ALBC) is commonly used in total knee arthroplasty (TKA), especially among high-risk patients. While previous studies have reported on the efficacy of ALBC in reducing the...
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Routine Intraoperative Bacterial Culture May Be Needed in Complicated Appendicitis

Son JT, Lee GC, Kim HO, Kim T, Lee D, Lee SR, Jung KU, Kim H, Chun HK

Purpose: Choosing the appropriate antibiotic is important for treatment of complicated appendicitis. However, increasing multidrug resistant bacteria have been a serious problem for successful treatment. This study was designed to...
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Prevalence of Multidrug-Resistant Organisms and Risk Factors for Carriage among Patients Transferred from Long-Term Care Facilities

Jeong H, Kang S, Cho HJ

Background: Patient transport between acute care hospitals and long-term care facilities (LTCFs) plays a significant role in microbial migration. The study aimed to estimate the prevalence and risk factors associated...
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