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Structural Insights for β-Lactam Antibiotics

Kim D, Kim S, Kwon Y, Kim Y, Park H, Kwak K, Lee H, Lee JH, Jang KM, Kim D, Lee SH, Kang LW

Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds...
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How Does Medical Policy on the Use of Prophylactic Antibiotics Affect Medical Costs, Length of Hospital Stay, and Antibiotic Use in Orthopedics?

Kim SH, Jang SY, Cha Y, Kim BY, Lee HJ, Kim GO

Purpose: The purpose of this study was to compare patients who had undergone spine surgery (SS) and hip arthroplasty surgery (HAS) and to analyze how medical policies drawn from “The...
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Clinical Characteristics and Antibiotic Susceptibility of Staphylococcus lugdunensis Isolated from Skin Diseases: A Retrospective Single-Center Study

Jang YK, Lee HJ, Kim DH, Yoon MS, Shin JU

  • KMID: 2539547
  • Korean J Dermatol.
  • 2023 Feb;61(2):124-129.
Background: Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections. However, until recently, the role of S. lugdunensis as a skin pathogen remained underrated. Objective: The purpose of...
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No more tears from surgical site infections in interventional pain management

Lim S, Yoo YM, Kim KH

As the field of interventional pain management (IPM) grows, the risk of surgical site infections (SSIs) is increasing. SSI is defined as an infection of the incision or organ/space that...
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Korean Multicenter Study of Infectious Complications after Transurethral Prostate Surgery in Patients with Preoperative Sterile Urine

Yu SH, Jung SI, Hwang EC, Kim TH, Choi JD, Yoo KH, Lee JW, Koh DH, Bae S, Yang SO, Choi J, Min SK, Choi H

Purpose: To evaluate the efficacy of antibiotic prophylaxis and determine the risk factors of infectious complications after transurethral surgery of the prostate. Materials and Methods: Seven hundred and seventy-two patients who...
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Implementation of Procalcitonin in Antibiotic Stewardship: Derivation of a Consensus Algorithm for Procalcitonin Use in Clinical Practice

Park DW, Choi JY, Kim CJ, Kim JH, Kim HB, Lee DG

Reducing antibiotics overuse is essential to minimize antibiotics related side effects and to prevent the emergence of multidrug-resistant bacteria. Procalcitonin (PCT) guided antibiotics therapy has been reported to be safe...
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Current Status of Antibiotic Stewardship and the Role of Biomarkers in Antibiotic Stewardship Programs

Kim CJ

The importance of antibiotic stewardship is increasingly emphasized in accordance with the increasing incidences of multidrug-resistant organisms and accompanying increases in disease burden. This review describes the obstacles in operating...
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The Unusual Cause of Prosthetic Joint Infection: Outcomes of Nontuberculous Mycobacteria Treatment Following Primary Total Knee Arthroplasty

Iqbal F, Noor SS, Najjad KR, Ishaque S, Memon N, Zano S

Background: Nontuberculous mycobacterium (NTM) is a rare cause of prosthetic joint infection (PJI) following primary total knee arthroplasty (TKA). NTM causes a variety of infections, mainly divided into pulmonary and...
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Is antibiotic prophylaxis necessary after endoscopic ultrasound–guided fine-needle aspiration of pancreatic cysts?

Hakim S, Gjeorgjievski M, Khan Z, Cannon ME, Yu K, Patil P, DaVee RT, Guha S, Badillo R, Jamil L, Thosani N, Ramireddy S

Background/Aims: Current society guidelines recommend antibiotic prophylaxis for 3 to 5 days after endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA) of pancreatic cystic lesions (PCLs). The overall quality of the evidence supporting...
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Incidence and risk factors associated with progression to severe pneumonia among adults with non-severe Legionella pneumonia

Huh JY, Choi SH, Jo KW, Huh JW, Hong SB, Shim TS, Lim CM, Koh Y

Background: Legionella species are important causative organisms of severe pneumonia. However, data are limited on predictors of progression to severe Legionella pneumonia (LP). Therefore, the risk factors for LP progression...
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Comparison of Inflammatory Markers Changes in Patients Who Used Postoperative Prophylactic Antibiotics within 24 Hours after Spine Surgery and 5 Days after Spine Surgery

Youn G, Choi MK, Kim SB

Objective : C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count are inflammatory markers used to evaluate postoperative infections. Although these markers are non-specific, understanding...
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Comparison of amikacin with fosfomycin as an add-on to ciprofloxacin for antibiotic prophylaxis in transrectal prostate biopsy: A single-center retrospective study

Yu SH, Jung SI, Ryu JW, Kim MS, Chung HS, Hwang EC, Kwon DD

Purpose: To assess the effect of ciprofloxacin (CP) and fosfomycin compared with CP and amikacin in patients with a fluoroquinolone (FQ)-resistant rectal flora who have undergone transrectal ultrasound-guided prostate biopsy...
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Bioprospecting of Endophytic Fungi as Promising Anti-MRSA Agents

Wei YM, Tan JS, Tang HW, Tong WY, Leong CR, Tan WN

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are...
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Short-Term Topical Antibiotic Treatment in Nasal Cavity Actinomycosis: Case Report and Literature Review

Mun YM, Im SK, Lee GM, Jung SY

Actinomycosis is a rare acute-to-chronic bacterial infection caused by Actinomyces. A 7-year-old healthy girl presented with left-sided nasal obstruction and purulent discharge. She had no special medical or trauma history,...
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Myths and Misconceptions around Antibiotic Resistance: Time to Get Rid of Them

Amábile-Cuevas CF

The antibiotic resistance arena is fraught with myths and misconceptions, leading to wrong strategies to combat it. It is crucial to identify them, discuss them in light of current evidence,...
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Risk factors associated with development of coinfection in critically Ill patients with COVID-19

Orsini EM, Sacha GL, Han X, Wang X, Duggal A, Rajendram P

Background: At outset of the coronavirus disease 2019 (COVID-19) pandemic, the significance of bacterial and fungal coinfections in individuals with COVID-19 was unknown. Initial reports indicated that the prevalence of...
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Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy

Park DH, Lee CM, Chang E, Kang CK, Park WB, Kim NJ, Choe PG, Oh Md

Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has...
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Neonatal sepsis-causing bacterial pathogens and outcome of trends of their antimicrobial susceptibility a 20-year period at a neonatal intensive care unit

Song WS, Park HW, Oh MY, Jo JY, Kim CY, Lee JJ, Jung E, Lee BS, Kim KS, Kim EAR

Background: Due to increases in the number of infants born with younger gestational age (GA) and lower birth weight, the incidence of neonatal sepsis is increasing. Purpose: We investigated the changes...
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Prevalence of Empiric Antibacterial Therapy, Community-Acquired Bacterial Superinfection, and Antibiotic-Associated Adverse Reactions among Patients with COVID-19 Pneumonia Admitted in Makati Medical Center from March 2020 to March 2021

Galang – De Leon WAM, Buensalido JAL

Background: Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus which was first discovered in Wuhan, China. Being a viral illness, antibacterial agents theoretically have no role in patients...
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Comparison of erythrocyte sedimentation rate and C-reactive protein in patients with distal radius fractures according to the prophylactic antibiotic period: 1 day versus 1 week

Kim DG, Kwack BH

Purpose: Surgical site infection is a serious postoperative complication. Most surgical site infections after distal radius fracture (DRF) surgery are superficial and early-onset, and they can be prevented by prophylactic...
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