Korean J Pediatr.  2009 Jan;52(1):119-123. 10.3345/kjp.2009.52.1.119.

Hand-Foot syndrome induced by sorafenib, a multitargeted tyrosine kinase inhibitor, in a patient with advanced renal cell carcinoma

• Lee SH
• Noh SH
• Kim SY
• Jang KY
• Hwang PH

• KMID: 2037347
• DOI: http://doi.org/10.3345/kjp.2009.52.1.119

Abstract

Renal cell carcinoma (RCC) arising from epithelial cells of the renal tubules is a highly aggressive and malignant tumor in all ages; however, it rarely occurs in children. the standard treatment for RCC is radical nephrectomy with lymph node dissection when the tumor is localized and can be completely resected. Adjuvant chemotherapy, radiotherapy, and immunotherapy are used for pediatric patients with advanced RCC involving lymph nodes or metastatic lesions. Sorafenib is an oral, multikinase inhibitor that has recently been approved for use in metastatic RCC. Common toxicities that have been reported include dermatologic changes such as rash or desquamation and hand-foot skin reaction, diarrhea, fatigue, alopecia, and hypertension. In particular, hand-foot syndrome (HFS) an erythematous skin lesion of the palms and solesis most often caused by cytostatic chemotherapeutic agents. In this report, we have studied a 14-year-old female patient with hand-foot syndrome that occurred in association with sorafenib for the treatment of metastatic RCC. Furthermore, this case demonstrates that reversal of complications can be achieved by discontinuing the drug and intervention with topical steroids, vitamin E, and high-dose pyridoxine.

Keyword

Hand-Foot syndrome (HFS); Sorafenib; Renal cell carcinoma

MeSH Terms

Adolescent
Alopecia
Carcinoma, Renal Cell
Chemotherapy, Adjuvant
Child
Diarrhea
Epithelial Cells
Exanthema
Fatigue
Female
Hand-Foot Syndrome
Humans
Hypertension
Immunotherapy
Lymph Node Excision
Lymph Nodes
Nephrectomy
Niacinamide
Phenylurea Compounds
Protein-Tyrosine Kinases
Pyridoxine
Robenidine
Skin
Steroids
Tyrosine
Vitamin E
Vitamins
Niacinamide
Phenylurea Compounds
Protein-Tyrosine Kinases
Pyridoxine
Robenidine
Steroids
Tyrosine
Vitamin E
Vitamins