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GM2 Gangliosidosis II

Choi SY, Park JH, Lee JS, Coe CJ, Han SH, Lee EH

  • KMID: 2007265
  • J Korean Child Neurol Soc.
  • 1999 Dec;7(2):244-249.
GM2 gangliosidosis II(Sandhoff disease) is a lysosomal storage disease due to deficiency of beta-hexosaminidase activity, transmitted by mode of autosomal recessive. Clinical features are so variable, ranging from infantile onset...
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Intracellular Ca2+ Mobilization and Beta-hexosaminidase Release Are Not Influenced by 60 Hz-electromagnetic Fields (EMF) in RBL 2H3 Cells

Hwang YH, Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Ryu JS, Sohn UD, Gimm YM, Myung SH, Sim SS

The effects of extremely low frequency electromagnetic fields (EMF) on intracellular Ca2+ mobilization and cellular function in RBL 2H3 cells were investigated. Exposure to EMF (60 Hz, 0.1 or 1...
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A Case of Tay-Sachs Disease in Korea Diagnosed by Enzyme Assay and DNA Analysis

Jin HS, Choi JH, Yoo HW

  • KMID: 2279500
  • Korean J Pediatr.
  • 2004 Dec;47(12):1360-1363.
Tay-Sachs disease is an autosomal recessive, neurodegenerative disorder that results from excessive storage of the cell membrane glycolipid, and GM2 ganglioside within the lysosomes of cells. This disease is caused...
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Anti-Oxidative and Anti-Inflammatory Effect of Water Extract from Perillae semen in RBL-2H3 Cells

Kim JM, Kim DJ, Kim TH, Kim HS, Choe M

The present study was to investigate anti-oxidative and anti-inflammatory activity of Perillae semen in RBL-2H3 basophilic leukemia cells. Inhibitory effect of Perillae semen onto free radical generation was determined by...
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Functions of Siglecs in Allergic Inflammation

Lee HH

  • KMID: 2051628
  • Pediatr Allergy Respir Dis.
  • 2006 Sep;16(3):197-205.
Siglecs are sialic acid binding Ig-like lectins, subset of the immunoglobulin superfamily. They are characterized by a homologous N-terminal V-set Ig-like domain and C2 set Ig-like domains. N-terminal domains...
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Identification of Functionally Different Rat IgE in RBL-2H3 Exocytosis

Kim JS, Cho S, Joo KH, Lee JS, Conrad DH, Cho SW

BACKGROUND: IgE is closely related to the development of allergies. However, the poor relationship between the specific IgE level and the severity of allergic diseases suggests the possibility of functionally...
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Selective Cannabinoid Receptor-1 Agonists Regulate Mast Cell Activation in an Oxazolone-Induced Atopic Dermatitis Model

Nam G, Jeong SK, Park BM, Lee SH, Kim HJ, Hong SP, Kim B, Kim BW

BACKGROUND: Many inflammatory mediators, including various cytokines (e.g. interleukins and tumor necrosis factor [TNF]), inflammatory proteases, and histamine are released following mast cell activation. However, the endogenous modulators for mast...
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Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells

Chung MJ, Kim JM, Lee S, Kim T, Kim D, Baek J, Kim T, Lee J, Kim K, Yoon JA, Choe M

  • KMID: 2313580
  • Nutr Res Pract.
  • 2012 Apr;6(2):97-105.
Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its...
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