- Molecular Biologic Techniques in Cytopathologic Diagnosis
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Hwang TS
- KMID: 1472615
- Korean J Pathol.
- 2009 Oct;43(5):387-392.
- doi: 10.4132/KoreanJPathol.2009.43.5.387
Molecular diagnosis is an application of the knowledge on molecular mechanisms of disease to diagnosis, therapeutic decision-making, and prognostication. Basically any molecular diagnostic technique could be used in molecular diagnostic... -
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- Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes
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Lee HJ, Kim PH
- KMID: 1474585
- Immune Netw.
- 2009 Aug;9(4):133-137.
- doi: 10.4110/in.2009.9.4.133
We have recently shown that activin A, a member of TGF-beta superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the present study, we further characterized... -
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- Radiotherapy Response in Microsatellite Instability Related Rectal Cancer
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Shin JS, Tut TG, Yang T, Lee CS
- KMID: 1837564
- Korean J Pathol.
- 2013 Feb;47(1):1-8.
Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no... -
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- Mutation and Expression of DNA2 Gene in Gastric and Colorectal Carcinomas
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Lee SH, Kim YR, Yoo NJ, Lee SH
- KMID: 2277572
- Korean J Pathol.
- 2010 Aug;44(4):354-359.
BACKGROUND: Deregulation of DNA repair and replication are involved in cancer development. DNA2 is a nuclease/helicase that plays roles in DNA repair and replication. The aim of this study was... -
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- Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients
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Kim SH, Ahn BK, Nam YS, Pyo JY, Oh YH, Lee KH
- KMID: 2372645
- J Gastric Cancer.
- 2010 Dec;10(4):149-154.
PURPOSE: Replication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the... -
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- Qualitative and quantitative evaluation of root injury risk potentially burdening insertion of miniscrew implants
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Antoszewska J, Trzesniewska P, Kawala B, Ludwig B, Park HS
- KMID: 2274247
- Korean J Orthod.
- 2011 Apr;41(2):112-120.
- doi: 10.4041/kjod.2011.41.2.112
OBJECTIVE: Microscrew implants (MSIs) offer many advantages, but some complications are known to occur during their insertion. One of the most commonly reported complications is root injury. Our aim was... -
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- Regression of Hyperplastic Gastric Polyp after Helicobacter pylori Eradication
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Lim SA, Yun JW, Yoon D, Choi W, Kim SH, Choe JW, Kim MN, Kang EJ, Park JJ, Joo MK, Lee BJ, Bak YT, Lee SW, Park JT
- KMID: 1935712
- Korean J Gastrointest Endosc.
- 2011 Feb;42(2):74-82.
BACKGROUND/AIMS: Recent studies have suggested that the eradication of Helicobacter pylori (Hp) may lead to the regression of hyperplastic polyps (HPPs) in the stomach. We evaluated the sizes of HPPs... -
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- Immunomodulatory effect of canine periodontal ligament stem cells on allogenic and xenogenic peripheral blood mononuclear cells
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Kim HS, Kim KH, Kim SH, Kim YS, Koo KT, Kim TI, Seol YJ, Ku Y, Rhyu IC, Chung CP, Lee YM
- KMID: 1783570
- J Periodontal Implant Sci.
- 2010 Dec;40(6):265-270.
- doi: 10.5051/jpis.2010.40.6.265
PURPOSE: The aim of this study was to investigate the immunomodulatory effects of canine periodontal ligament stem cells on allogenic and xenogenic immune cells in vitro. METHODS: Mixed cell cultures consisting... -
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- Microsatellite Instability-low Colorectal Carcinomas: Are They Comparable with Microsatellite Stable Cancer?
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Paek OJ, Oh SY, Kim YB, Suh KW
- KMID: 2198814
- J Korean Soc Coloproctol.
- 2010 Apr;26(2):145-151.
- doi: 10.3393/jksc.2010.26.2.145
PURPOSE: Microsatellite instability-high (MSI-H) colorectal cancer (CRC) displays a well-described distinct phenotype, but the true biological significance of MSI-low (L) is still uncertain. To clarify the significance of this MSI-L,... -
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- Markers for Screening Lynch Syndrome Are Reliable and Useful for Identifying the Specimen Mislabeling
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Byeon SJ, Choi J, Nam KH, Jang BG, Lee HE, Kim MA, Kim WH
- KMID: 2011980
- Korean J Pathol.
- 2012 Apr;46(2):131-136.
BACKGROUND: During specimen processing in surgical pathology laboratories, specimen-related adverse events (SRAEs), such as mislabeling and specimen mixed-up might occur. In these situations, molecular techniques using short tandem repeat (STR)... -
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- Loss of Heterozygosity on Chromosome 15q15 Near Thrombospondin-1 Gene in Breast Carcinomas
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Kim J, Kim KM, Lee H, Lee K, Rhyu MG, Lee A, Kang SJ, Lee KY
- KMID: 1979339
- Korean J Pathol.
- 2009 Jun;43(3):221-230.
BACKGROUND: Chromosome 15q15 near the thrombospondin-1 (THBS-1) gene may be associated with tumor progression and metastasis. To clarify the potential role of the15q15 region in progression of breast carcinoma, we... -
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- Genetic Instability in Gastric Epithelial Neoplasias Categorized by the Revised Vienna Classification
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Chung WC, Jung SH, Lee KM, Paik CN, Kwak JW, Jung JH, Yoo JY, Lee MK, Chung IS
- KMID: 2284183
- Gut Liver.
- 2010 Jun;4(2):179-185.
BACKGROUND/AIMS: The aim of this study was to determine the structural chromosomal aberrations, such as loss of heterozygosity (LOH) and microsatellite instability (MSI), at multiple tumor suppressor gene loci in... -
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- Alterations in the Kinetics of CD4+ T Cell Responses with Aging
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Hong MS, Dan JM, Lee WW, Kang I
- KMID: 2334877
- J Korean Rheum Assoc.
- 2009 Dec;16(4):271-280.
OBJECTIVE: Alterations in the immune system occur with aging, and these contribute to an increased risk of infection and malignancy. The age-associated changes in T cell immunity range from single... -
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- Insulin Resistance in Children and Adolescents Born Small for Gestational Age
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Lee HJ, Jung MK, Park HK, Yang S, Hwang IT, Lee HR
- KMID: 2321961
- J Korean Soc Pediatr Endocrinol.
- 2008 Jun;13(1):86-93.
PURPOSE: The aim of this study was to determine whether insulin resistance may be present and to analyze factors affecting the development of insulin resistance in children and adolescents born... -
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- Mutational Analysis of TTK Gene in Gastric and Colorectal Cancers with Microsatellite Instability
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Ahn CH, Kim YR, Kim SS, Yoo NJ, Lee SH
- KMID: 1972676
- Cancer Res Treat.
- 2009 Dec;41(4):224-228.
PURPOSE: The TTK gene plays a crucial role in regulation of the mitotic checkpoint. The TTK gene has an A9 mononucleotide repeat in the coding sequences, which harbors mutations in... -
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- The Relation between Microsatellite Instability and the Thymidylate Synthase Expression in Gastric Cancer
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Ko HS, Ahn CW, Kang HY, Kim KI, Hong SP, Ahn DH
- KMID: 2372914
- J Korean Gastric Cancer Assoc.
- 2008 Dec;8(4):169-175.
PURPOSE: The main target of 5-fluorouracil (5-FU) is thymidylate synthase (TS). A high TS expression has been identified as promoting resistance to 5-FU. For colorectal cancers, the response to 5-FU... -
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- Overexpression of p53, Mutation of hMLH1 and Microsatellite Instability in Gastric Carcinomas: Clinicopathologic Implications and Prognosis
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Kwon J, Lee JH, Jee YS, Park DJ, Kim HH, Lee HJ, Yang HK, Lee KU, Lee HS
- KMID: 2211978
- J Korean Surg Soc.
- 2010 Aug;79(2):94-102.
- doi: 10.4174/jkss.2010.79.2.94
PURPOSE: Mutated p53 is a tumor suppressor gene, hMLH1 is a mismatch repair gene, and hypermethylation of hMLH1 follows microsatellite instability (MSI). This research's aim is to investigate mutated p53,... -
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- Molecular Biological Characteristics of Differentiated Early Gastric Cancer on the Basis of Mucin Expression
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Shin N, Kim HY, Kim WK, Park MG, Kim KB, Shin DH, Choi KU, Kim JY, Lee CH, Huh GY, Sol MY, Park DY
- KMID: 2277522
- Korean J Pathol.
- 2011 Feb;45(1):69-78.
BACKGROUND: It is clear that the biologic characteristics of gastric cancer are different on the basis of mucin phenotypes. However, there are unabated controversies on the exact biologic differences of... -
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- Clinicopathological Characteristics of Colorectal Cancer according to Microsatellite Instability
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Suk KT, Kim HS, Lee JH, Kim BR, Kim MY, Kim JW, Baik SK, Kwon SO, Chong Y, Cho MY
- KMID: 2174113
- Intest Res.
- 2009 Jun;7(1):14-21.
BACKGROUND/AIMS: Microsatellite instability (MSI) is associated with mutations in the DNA mismatch repair system and accounts for 10-15% of all cases of sporadic colorectal cancer (CRC). However, the characteristics and... -
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- Microsatellite Instability and p53 Gene Loss of Heterozygosity in Hepatocellular Carcinoma
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Kim JS, Lim MS, Kim DJ, Kim JS, Kim KS, Kim HK, Cho SJ, Kwon MJ, Nam ES, Choi KC, Shin HS, Chae GB
- KMID: 2083315
- Korean J Hepatobiliary Pancreat Surg.
- 2009 Sep;13(3):143-151.
PURPOSE: Hepatocellular carcinoma (HCC) shows various molecular and genetic alterations in its development and progression. Recently, microsatellite instability (MSI) and the loss of heterozygosity (LOH), have been postulated as useful... -
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