- The Effect of Recombinant Tyrosine Hydroxylase Expression on the Neurogenic Differentiation Potency of Mesenchymal Stem Cells
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Turac G, Duruksu G, Karaoz E
- KMID: 2413271
- Neurospine.
- 2018 Mar;15(1):42-53.
- doi: 10.14245/ns.1836010.005
OBJECTIVE: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells... -
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- System-Wide Expression and Function of Olfactory Receptors in Mammals
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Oh SJ
- KMID: 2413245
- Genomics Inform.
- 2018 Mar;16(1):2-9.
- doi: 10.5808/GI.2018.16.1.2
Olfactory receptors (ORs) in mammals are generally considered to function as chemosensors in the olfactory organs of animals. They are membrane proteins that traverse the cytoplasmic membrane seven times and... -
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- MicroRNA-29 Family Suppresses the Invasion of HT1080 Human Fibrosarcoma Cells by Regulating Matrix Metalloproteinase 2 Expression
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Kim JH, Jeon S, Shin BA
- KMID: 2379290
- Chonnam Med J.
- 2017 May;53(2):161-167.
- doi: 10.4068/cmj.2017.53.2.161
Matrix metalloproteinase 2 (MMP2) is a potent protumorigenic, proangiogenic, and prometastatic enzyme that is overexpressed in metastatic cancer. Although there have been various studies on the MMP2 gene, further studies... -
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- Regulation of vascular smooth muscle phenotype by cross-regulation of krüppel-like factors
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Ha JM, Yun SJ, Jin SY, Lee HS, Kim SJ, Shin HK, Bae SS
- KMID: 2371066
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):37-44.
- doi: 10.4196/kjpp.2017.21.1.37
Regulation of vascular smooth muscle cell (VSMC) phenotype plays an essential role in many cardiovascular diseases. In the present study, we provide evidence that krüppel-like factor 8 (KLF8) is essential... -
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- The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery
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Lee W, Kim HS, Hwang SS, Lee GR
- KMID: 2396798
- Exp Mol Med.
- 2017 Nov;49(11):e393.
- doi: 10.1038/emm.2017.157
Naive CD4 T cells activated by antigen-presenting cells (APCs) undergo terminal differentiation in the periphery. Multiple mechanisms determine their fates, that is, whether they differentiate into conventional T (Tconv) cells... -
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- CKAP2 phosphorylation by CDK1/cyclinB1 is crucial for maintaining centrosome integrity
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Yoo BH, Kang DS, Park CH, Kang K, Bae CD
- KMID: 2388352
- Exp Mol Med.
- 2017 Jul;49(7):e354.
- doi: 10.1038/emm.2017.92
Previously, we have reported that CKAP2 is involved in the maintenance of centrosome integrity, thus allowing for proper mitosis in primary hepatocytes. To understand this biological process, we identified the... -
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- ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells
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Baik SH, Lee J, Lee YS, Jang JY, Kim CW
- KMID: 2361509
- Exp Mol Med.
- 2016 Mar;48(3):e222.
- doi: 10.1038/emm.2015.126
MicroRNAs (miRNAs) are negative regulators of gene expression, and miRNA deregulation is found in various tumors. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by short hairpin... -
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- Amplification of Stem Genes: New Potential Metastatic Makers in Patients with an Early Form of Breast Cancer
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Tsyganov M, Ibragimova MK, Pevzner AM, Doroshenko AV, Slonimskaya EM, Litviakov
- KMID: 2466006
- J Korean Med Sci.
- 2019 Dec;34(49):e312.
- doi: 10.3346/jkms.2019.34.e312
BACKGROUND: According to our previous studies, the presence of amplifications of stem genes can lead to their ectopic expression and this is associated with an increased activity of tumor stem... -
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- Expression of polo-like kinase 1 in pre-implantation stage murine somatic cell nuclear transfer embryos
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Moon J, Roh S
- KMID: 2434771
- J Vet Sci.
- 2019 Jan;20(1):2-9.
- doi: 10.4142/jvs.2019.20.1.2
Somatic cell nuclear transfer (SCNT) has various applications in research, as well as in the medical field and animal husbandry. However, the efficiency of SCNT is low and the accurate... -
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- HOXC10 suppresses browning of white adipose tissues
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Ng Y, Tan SX, Chia SY, Tan HY, Gun SY, Sun L, Hong W, Han W
- KMID: 2375022
- Exp Mol Med.
- 2017 Feb;49(2):e292.
- doi: 10.1038/emm.2016.144
Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here... -
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- Bcl11b Regulates IL-17 Through the TGF-β/Smad Pathway in HDM-Induced Asthma
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Chen S, Han Y, Chen H, Wu J, Zhang M
- KMID: 2418051
- Allergy Asthma Immunol Res.
- 2018 Sep;10(5):543-554.
- doi: 10.4168/aair.2018.10.5.543
PURPOSE: T helper (Th) 17 cells play a critical role in the development of asthma, but the underlying mechanism of how interleukin (IL)-17 is regulated in allergic airway inflammation is... -
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- microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression
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Lee H, Kim C, Kang H, Tak H, Ahn S, Yoon SK, Kuh HJ, Kim W, Lee EK
- KMID: 2382689
- Exp Mol Med.
- 2017 May;49(5):e327.
- doi: 10.1038/emm.2017.33
Acquisition of resistance to anti-cancer drugs is a significant obstacle to effective cancer treatment. Although several efforts have been made to overcome drug resistance in cancer cells, the detailed mechanisms... -
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- Ectopically Expressed Membrane-bound Form of IL-9 Exerts Immune-stimulatory Effect on CT26 Colon Carcinoma Cells
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Do Thi VA, Park SM, Lee H, Kim YS
- KMID: 2404894
- Immune Netw.
- 2018 Feb;18(1):e12.
- doi: 10.4110/in.2018.18.e12
IL-9 is a known T cell growth factor with pleiotropic immunological functions, especially in parasite infection and colitis. However, its role in tumor growth is controversial. In this study, we... -
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- Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin
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Jeong BY, Cho KH, Jeong KJ, Park YY, Kim JM, Rha SY, Park CG, Mills GB, Cheong JH, Lee HY
- KMID: 2438365
- Exp Mol Med.
- 2018 Jan;50(1):e435.
- doi: 10.1038/emm.2017.248
The small GTP-binding protein Rab25 is associated with tumor formation and progression. However, recent studies have shown discordant effects of Rab25 on cancer cell progression depending on cell lineage. In... -
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- miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells
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Cho YM, Kim TM, Kim DH, Kim DH, Jeong SW, Kwon OJ
- KMID: 2361513
- Exp Mol Med.
- 2016 Apr;48(4):e226.
- doi: 10.1038/emm.2016.3
Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors. We have previously demonstrated that Wnt10b transcription during adipogenesis is negatively regulated by... -
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- MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase
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Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P
- KMID: 2463798
- Yonsei Med J.
- 2019 Dec;60(12):1187-1194.
- doi: 10.3349/ymj.2019.60.12.1187
PURPOSE: Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved... -
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- Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver
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Cho KW, Cho DH
- KMID: 2434096
- Yeungnam Univ J Med.
- 2019 Jan;36(1):26-35.
- doi: 10.12701/yujm.2019.00059
BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in... -
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