- Cryptotanshinone Inhibits Lipid Accumulation in Differentiating 3T3-L1 Preadipocytes by Down-regulating C/EBP-α, PPAR-γ, FAS, Perilipin A, and STAT-3
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Park YK, Jang BC
- KMID: 2469571
- Keimyung Med J.
- 2019 Dec;38(1,2):1-10.
- doi: 10.0000/kmj.2019.38.1.1
Differentiation of preadipocyte, also named adipogenesis, leads to the phenotype of mature adipocyte that is filled with many lipid droplets. Excessive lipid accumulation in adipocytes leads to the development of... -
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- Cryptotanshinone Inhibits Lipid Accumulation in Differentiating 3T3-L1 Preadipocytes by Down-regulating C/EBP-α, PPAR-γ, FAS, Perilipin A, and STAT-3
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Park YK, Jang BC
- KMID: 2469552
- Keimyung Med J.
- 2019 Dec;38(1-2):1-10.
- doi: 10.0000/kmj.2019.38.1.1
Differentiation of preadipocyte, also named adipogenesis, leads to the phenotype of mature adipocyte that is filled with many lipid droplets. Excessive lipid accumulation in adipocytes leads to the development of... -
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- Cryptotanshinone Inhibits Lipid Accumulation in Differentiating 3T3-L1 Preadipocytes by Down-regulating C/EBP-α, PPAR-γ, FAS, Perilipin A, and STAT-3
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Park YK, Jang BC
- KMID: 2469544
- Keimyung Med J.
- 2019 Dec;38(1):1-10.
- doi: 10.0000/kmj.2019.38.1.1
Differentiation of preadipocyte, also named adipogenesis, leads to the phenotype of mature adipocyte that is filled with many lipid droplets. Excessive lipid accumulation in adipocytes leads to the development of... -
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- Pear pomace water extract inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes
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Rhyu J, Kim MS, You MK, Bang MA, Kim HA
- KMID: 2313708
- Nutr Res Pract.
- 2014 Feb;8(1):33-39.
Obesity occurs when a person's calorie intake exceeds the amount of energy burns, which may lead to pathologic growth of adipocytes and the accumulation of fat in the tissues. In... -
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- Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte
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Choi BH, Ahn IS, Kim YH, Park JW, Lee SY, Hyun CK, Do MS
- KMID: 1115937
- Exp Mol Med.
- 2006 Dec;38(6):599-605.
Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the... -
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- NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARg expression
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Chae GN, Kwak SJ
- KMID: 1093616
- Exp Mol Med.
- 2003 Oct;35(5):431-437.
TNF-alpha, a trimeric cytokine, was known to inhibit differention of preadipocytes to adipocytes. In the present study, we investigated signal mediators working downstream of TNF-alpha using murine 3T3-L1 cells. TNF-alpha... -
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- The Inhibitory Effect of Testosterone on PPARγ-induced Adipogenesis
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Jeong S
- KMID: 2328214
- Korean J Obes.
- 2016 Jun;25(2):68-76.
- doi: 10.7570/kjo.2016.25.2.68
BACKGROUND: Peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in adipocyte differentiation. Testosterone is well known for inhibiting adipocyte metabolism in men. To investigate the inhibitory mechanism of testosterone... -
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- Effect of Dexamethasone, Retinoid Acid and Vitamin D on the Transdifferentiation of 3T3-L1 and KS483
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Song KJ, Yang JY, Park JW, Seo KB, Choi MK
- KMID: 2105889
- J Korean Orthop Assoc.
- 2002 Aug;37(4):544-551.
PURPOSE: In this study, the effects of dexamethasone, retinoic acid and vitamin D on the transdifferentiation of adipocyte and osteoblast were investigated using 3T3-L1 and KS483 cells, pre-adipocyte and pre-osteoblast... -
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- Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes
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Kwak SH, Kim YH
- KMID: 2459822
- J Obes Metab Syndr.
- 2019 Jun;28(2):105-111.
- doi: 10.7570/jomes.2019.28.2.105
BACKGROUND: An excess storage of body fat causes obesity. Since obesity increases risk of chronic diseases, it is important to inhibit excessive storage of fat. Zaluzanin C is a sesquiterpene... -
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- Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation
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Zhang XH, Huang B, Choi SK, Seo JS
- KMID: 2313606
- Nutr Res Pract.
- 2012 Aug;6(4):286-293.
Resveratrol (3,4,5-trihydroxy-trans-stilbene), a phytoalexin found in grape skin, grape products, and peanuts as well as red wine, has been reported to have various biological and pharmacological properties. The purpose of... -
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- TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells
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Kim SJ, Kim T, Choi HN, Cho EJ, Park JB, Jeon BH, Lee SD
- KMID: 2364269
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):649-655.
- doi: 10.4196/kjpp.2016.20.6.649
TonEBP belongs to the Rel family of transcription factors and plays important roles in inflammation as well as kidney homeostasis. Recent studies suggest that TonEBP expression is also involved in... -
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- Anti-obesity effect of EGCG and glucosamine-6-phosphate through decreased expression of genes related to adipogenesis and cell cycle arrest in 3T3-L1 adipocytes
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Kim KB, Jang SH
- KMID: 2327454
- J Nutr Health.
- 2014 Feb;47(1):1-11.
PURPOSE: Several studies have proven that EGCG, the primary green tea catechin, and glucosamine-6-phosphate (PGlc) reduce triglyceride contents in 3T3-L1 adipocytes. The objective of this study is to evaluate the... -
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- The Effects of Ginseng Saponin-Re, Rc and Green Tea Catechine; ECGC (Epigallocatechin Gallate) on Leptin, Hormone Sensitive Lipase and Resistin mRNA Expressions in 3T3-L1 Adipocytes
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Kim SO, Lee HE, Choe WK
- KMID: 2270060
- Korean J Nutr.
- 2006 Dec;39(8):748-755.
The purpose of this study was to find out effects of treatment of ginsenoside Re, Rc and EGCG on mRNA expressions of leptin, hormone sensitive lipase (HSL) and resistin in... -
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- The Effects of D-Chiro-Inositol on Glucose Metabolism in 3T3-L1 Cells
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Park KS, Lee JM, Ku BJ, Jo YS, Lee SK, Min KW, Han KA, Kim HJ, Kim HJ
- KMID: 2298090
- Korean Diabetes J.
- 2008 Jun;32(3):196-203.
- doi: 10.4093/kdj.2008.32.3.196
BACKGROUND: The target of the treatment of metabolic syndrome and diabetes is an improvement of insulin resistance. D-chiro-inositol (DCI) plays a role in a phospholipid mediating intracellular insulin action. In... -
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- Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats
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Kim B, Choi KM, Yim HS, Park HT, Yim JH, Lee MG
- KMID: 2418853
- Yonsei Med J.
- 2018 Jan;59(1):85-91.
- doi: 10.3349/ymj.2018.59.1.85
PURPOSE: Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we... -
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- miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells
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Cho YM, Kim TM, Kim DH, Kim DH, Jeong SW, Kwon OJ
- KMID: 2361513
- Exp Mol Med.
- 2016 Apr;48(4):e226.
- doi: 10.1038/emm.2016.3
Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors. We have previously demonstrated that Wnt10b transcription during adipogenesis is negatively regulated by... -
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- Peanut sprout ethanol extract inhibits the adipocyte proliferation, differentiation, and matrix metalloproteinases activities in mouse fibroblast 3T3-L1 preadipocytes
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Kim WK, Kang NE, Kim MH, Ha AW
- KMID: 2313664
- Nutr Res Pract.
- 2013 Jun;7(3):160-165.
3T3-L1 preadipocyte were differentiated to adipocytes, and then treated with 0, 10, 20, and 40 microg/mL of peanut sprout ethanol extract (PSEE). The main component of PSEE is resveratrol which... -
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- B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages
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Kim MY, Kim DH, Do MS
- KMID: 2154223
- Exp Mol Med.
- 2013 Jan;45(1):e4.
3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-alpha and rosiglitazone. Here we... -
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- Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)
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Park M, Lee C, Lee HJ
- KMID: 2466679
- J Nutr Health.
- 2019 Feb;52(1):17-25.
- doi: 10.4163/jnh.2019.52.1.17
PURPOSE: Obesity is a major health problem of global significance because it is clearly associated with an increased risk of health problems, such as nonalcoholic fatty liver disease (NAFLD), diabetes,... -
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- Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats
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Song WY, Choi JH
- KMID: 2434082
- Nutr Res Pract.
- 2016 Oct;10(5):487-493.
- doi: 10.4162/nrp.2016.10.5.487
BACKGROUND/OBJECTIVES: Turmeric (Curcuma longa L.) has been reported to have many biological functions including anti-obesity. Leptin, peptide hormone produced by adipocytes and its concentration is increased in proportion to the... -
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