Korean J Gastroenterol.  2007 Dec;50(6):402-406.

A Case of Sclerosing Cholangitis Showing Response to Prednisolone

Affiliations
  • 1Department of Internal Medicine, Keimyung University College of Medicine, Daegu, Korea. seenae99@dsmc.or.kr
  • 2Department of Diagnostic Radiology,Keimyung University College of Medicine, Daegu, Korea.
  • 3Department of Pathology, Keimyung University College of Medicine, Daegu, Korea.

Abstract

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive fibrosis and destruction of intra- and extrahepatic bile ducts resulting in hepatic failure and death. Only the liver transplantation is the possible treatment for patients to survive. There has been a few reports that steroid is an effective treatment in autoimmune variant sclerosing cholangitis, which is thought to be a familial diseases with different etiology, and steroid responsive biliary strictures be named as immunoglobulin G4 (IgG4)-associated cholangitis (IAC). There is no reliable data regarding effective steroid treatment in autoimmue variant sclerosing cholangitis in Korea. We report a case of 32-year-old male with sclerosing cholangitis, who was diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) and liver biopsy, showing favorable response to prednisolone therapy.

Keyword

Sclerosing cholangitis; Immunoglobulin G4 associated cholangitis; Prednisolone

MeSH Terms

Adult
Anti-Inflammatory Agents/*therapeutic use
Cholangiopancreatography, Endoscopic Retrograde/methods
Cholangitis, Sclerosing/*diagnosis/pathology
Humans
Male
Prednisolone/*therapeutic use
Treatment Outcome
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