Korean J Lab Med.  2008 Jun;28(3):174-178. 10.3343/kjlm.2008.28.3.174.

Two Cases of Trisomy 19 as a Sole Chromosomal Abnormality in Myeloid Disorders

Affiliations
  • 1Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea. chscp@med.yu.ac.kr
  • 2Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea.
  • 3Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Abstract

Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary abnormality: however, trisomy 19 rarely occurs as a sole chromosomal abnormality and, to date, it has only been reported in 48 hematopoietic malignancies, 1 case of adenocarcinoma and 1 case of astrocytic tumor. Here, we report two additional cases of trisomy 19 as a sole karyotypic aberration in myeloid malignancies. One of these cases involved a 6-month-old male who was diagnosed with acute myeloid leukemia minimally differentiated. His karyotype was 47,XY,+19[20]. He expired 5 days after diagnosis. Another case occurred in an 80-yr-old female who had refractory anemia with excess blasts. Her karyotype was 47,XX,+19[16]/46,XX[4]. Four months later, her peripheral blood smears suggested that the disease had progressed, but she refused further evaluation. Based on a review of the existing literature and the results of this report, trisomy 19 not only as a secondary abnormality but also as a sole karyotypic aberration is strongly associated with myeloid disorder; however, it is not preferentially found in specific FAB subgroups of myelodysplasic syndrome or acute myeloid leukemia.

Keyword

Trisomy 19; Sole chromosomal abnormality; Myeloid malignancies

MeSH Terms

Acute Disease
Aged, 80 and over
Anemia, Refractory/*diagnosis/*genetics
*Chromosomes, Human, Pair 19
Female
Humans
Infant
Karyotyping
Leukemia, Myeloid/*diagnosis/*genetics
Male
*Trisomy

Figure

  • Fig. 1. The bone marrow aspirate of case 1 showed increase of blasts up to 96% (wright stain, × 1,000).

  • Fig. 2. The representative karyotype of case 1 shows 47,XY,+19.

  • Fig. 3. The bone marrow aspirate of case 2 was normocellular and contained 5.5% blasts (wright stain, ×1,000).


Reference

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