Korean J Gastroenterol.  2009 Oct;54(4):252-256. 10.4166/kjg.2009.54.4.252.

A Case of Atypical Solid-pseudopapillary Tumor of the Pancreas

Affiliations
  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. solee@chonbuk.ac.kr

Abstract

Solid-psudopapillary tumor is an uncommon pancreatic neoplasm of low malignant potential that most frequently affect young woman. Solid-psudopapillary tumor are histologically, clinically, and prognostically quite distinct from the more common ductal adenocarcinoma. Recently, we experienced a 36-year-old male who was suspected to have extrapancreatic tumor based on atypical radiologic imaging study, young age, and male sex, and finally diagnosed as solid-psudopapillary tumor on immunohistochemical stain examination. We report this case with review of the relevant literatures.

Keyword

Solid-pseudopapillary tumor; Male; Pancreatic tumor

MeSH Terms

Adult
Antigens, CD56/metabolism
Carcinoma, Papillary/*diagnosis/pathology/surgery
Cholangiopancreatography, Magnetic Resonance
Diagnosis, Differential
Humans
Male
Neprilysin/metabolism
Pancreatic Neoplasms/*diagnosis/pathology/surgery
Tomography, X-Ray Computed
Vimentin/metabolism

Figure

  • Fig. 1. Axial post-contrast CT finding showed a small (about 1.2 cm size) low attenuated mass (arrow) in arterial phase at the pancreatic neck.

  • Fig. 2. MRCP & ERCP images obtained at the time initial presentation. (A) MRCP image showed an about 1.3 cm sized hypovascular small nodular pancreatic mass (arrow) without ductal dilatation or vascular invasion at proximal body posterior pancreas. T1-weight MR image showed a low intensity, and T2-weight MR images showed a slight high signal intensity. (B) ERCP image showed a normal pancreatic duct without communication with mass.

  • Fig. 3. Gross pathology and microscopic finding. (A) Gross pathology showed a yellowish round shape and 1.7×1.5 cm sized mass without capsule. (B) Microscopic finding showed a solid areas composed of monomorphic epithelioid cells and papillary patterns (H&E stain, ×100).

  • Fig. 4. Immunohistochemical stain. (A) Chromogranin staining showed a focal positivity (Immunostain stain, ×400). (B) Antichymotrypsin staining showed a diffuse 3+ positivity (Immunostain stain, ×100). (C) β-catenin was stained of nucleus (Immunostain stain, ×100). (D) CD10 staining was positive (Immunostain stain, ×100). (E) CD56 staining was positive (Immunostain stain, ×100). (F) Vimentin staining showed positivity (Immunostain stain, ×100).


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