Korean J Ophthalmol.  2009 Jun;23(2):124-126. 10.3341/kjo.2009.23.2.124.

Serous Retinal Detachment Following Combined Photodynamic Therapy and Intravitreal Bevacizumab Injection

• Kim EY
• Kim JW
• Kim JB
• Lew HM

• KMID: 754732
• DOI: http://doi.org/10.3341/kjo.2009.23.2.124

Abstract

We report a case of serous retinal detachment following combined photodynamic therapy (PDT) and intravitreal bevacizumab injection in subfoveal choroidal neovascularization (CNV).

Keyword

Intravitreal bevacizumab injection; Photodynamic therapy; Serous retinal detachment

MeSH Terms

Administration, Oral
Angiogenesis Inhibitors/administration & dosage/*adverse effects
Antibodies, Monoclonal/administration & dosage/*adverse effects
Choroidal Neovascularization/*drug therapy/pathology
Diagnosis, Differential
Female
Fluorescein Angiography
Fundus Oculi
Glucocorticoids/administration & dosage
Humans
Injections
Middle Aged
Photochemotherapy/*adverse effects
Retinal Detachment/*chemically induced/diagnosis/drug therapy
Tomography, Optical Coherence
Triamcinolone/administration & dosage
Vascular Endothelial Growth Factor A
Vitreous Body

Figure

• 

  Fig. 1 (A) Fundoscopic photography and fluorescein angiography showing leakage of fluorescein dye consistent with subfoveal choroidal neovascularization (CNV) before combined photodynamic therapy (PDT) and intravtreal bevacizumab injection. (B) Leakage of fluorescein dye decreased two weeks after the combined PDT and intravtreal bevacizumab injection.

• 

  Fig. 2 Optical coherence tomography (OCT) before and after the combined photodynamic therapy (PDT) and intravtreal bevacizumab injection. (A) Before combined PDT and intravtreal bevacizumab injection, OCT image demonstrates a minimally hyporeflective area in the subneuroretinal space. (B) One day after the combined treatment, OCT image reveals significant enlargement of the hyporeflective area, representing the amount of fluid accumulation. (C) One week after taking the oral steroid, the subretinal fluid has absorbed nearly completely, similar to pretreatment OCT findings.

Reference

1. Yoo MH, Boo HD, Kim HK. Result of photodynamic therapy for idiopathic subfoveal choroidal neovascuarization. Korean J Ophthalmol. 2005. 19:264–268.

2. Avery RL, Pieramici DJ, Pieramici DJ, et al. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology. 2006. 113:363–372.

3. Dhalla MS, Shah GK, Blinder KJ, et al. Combined photodynamic therapy with verteporfin and intravitreal bevacizumab for choroidal neovascularization in are-related macular degeneration. Retina. 2006. 26:988–993.

4. Fung AE, Rosenfeld PJ, Reichel E. The international intravitreal Bevacizumab safty survey: using the internet to assess drug safety worldwide. Br J Ophthalmol. 2006. 90:1344–1349.

5. Rich RM, Rosenfeld PJ, Puliafito CA, et al. Short-term safety and efficacy of intravitreal Bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina. 2006. 26:495–511.

6. Schmidt-Erfurth U, Miller JW, Sickenberg M, et al. Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of retreatments in a phase 1 and 2 study. Arch Ophthalmol. 1999. 117:1177–1187.

7. Mennel S, Meyer CH, Eggarter F, Peter S. Transient serous retinal detachment in classic and occult choroidal neovascularization after photodynamic therapy. Am J Ophthalmol. 2005. 140:758–760.

8. Gelisken F, Inhoffen W, Partsch M, et al. Retinal pigment epithelial tear after photodynamic therapy for choroidal neovascularization. Am J Ophthalmol. 2001. 131:518–520.

9. Kim C, Chung H, Heo JW. Serous retinal detachment in patients with choroidal neovascularization following photodynamic therapy. J Korean Ophthalmol Soc. 2007. 48:1354–1361.

10. Shah CP, Hsu J, Garg SJ, et al. Retinal pigment epithelial tear after intravitreal bevacizumab injection. Am J Ophthalmol. 2006. 142:1070–1072.

11. Jalil A, Fenerty C, Charles S. Intravitreal bevacizumab (Avastin) causing acute glaucoma: an unreported complication. Eye. 2007. 21:1541.

12. Chung EJ, Koh HJ. Retinal detachment with macular hole following combined photodynamic therapy and intravitreal bevacizumab injection. Korean J Ophthalmol. 2007. 21:185–187.

13. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials--TAP report. Arch Ophthalmol. 1999. 117:1329–1345.

14. Costa RA, Farah ME, Cardillo JA, et al. Immediate indocyanine green angiography and optical coherence tomography evaluation after photodynamic therapy for subfoveal choroidal neovascularization. Retina. 2003. 23:159–165.