Korean J Ophthalmol.  2006 Sep;20(3):177-181. 10.3341/kjo.2006.20.3.177.

Thicknesses of the Fovea and Retinal Nerve Fiber Layer in Amblyopic and Normal Eyes in Children

• Kee SY
• Lee SY
• Lee YC

• KMID: 754576
• DOI: http://doi.org/10.3341/kjo.2006.20.3.177

Abstract

PURPOSE: This study was designed to assess and compare the thicknesses of the fovea and the retinal nerve fiber layer in normal children and children with amblyopia. METHODS: Optical Coherence Tomography (OCT) was performed on 26 children (52 eyes total) with unilateral amblyopia that was due to anisometropia or strabismus. OCT was also performed on 42 normal children (84 eyes), for a total of 136 eyes. Retinal thickness measurements were taken from the fovea, and the retinal nerve fiber layer thickness measurements were taken from the superior, inferior, nasal and temporal quadrants in the peripapillary region. RESULTS: The average age of the normal children was 8.5 years, and the average age of the children with amblyopia was 8.0 years. The average thickness of the fovea was 157.4 micrometer in normal eyes and was 158.8 micrometer in amblyopic eyes. The difference between the two groups was not statistically significant (p=0.551). The thicknesses of the superior, inferior, nasal and temporal quadrants of the retinal nerve fiber layer between the normal children and the children with amblyopia were also not statistically significant (p=0.751, 0.228, 0.696 and 0.228, respectively). However, for the children with anisometropic amblyopia and the children with strabismic amblyopia, the average thicknesses of the fovea were 146.5 micrometer and 173.1 micrometer, respectively, and the retinal nerve fiber layer thicknesses were measured to be 112.9 micrometer and 92.8 micrometer, respectively, and these were statistically significant differences (p=0.046, 0.034, respectively). CONCLUSIONS: Normal thicknesses of the fovea and the retinal nerve fiber layers were established, and there were no differences in the fovea and the retinal nerve fiber layer thickness found between normal children and children with amblyopia.

Keyword

Amblyopia; Foveal thickness; Optical coherence tomography; Retinal nerve fiber layer thickness

MeSH Terms

Tomography, Optical Coherence
Severity of Illness Index
Retrospective Studies
Retinal Ganglion Cells/*pathology
Nerve Fibers/*pathology
Male
Humans
Fovea Centralis/*pathology
Female
Child, Preschool
Child
Amblyopia/*pathology
Adolescent

Reference

1. Day S. Taylor D, editor. Normal and abnormal visual development. Pediatric Ophthalmology. 1990. v. 1:1st ed. London: Blackwell Scientific Publications;chap. 2.

2. Jin YH. Strabismus. 2001. 2nd ed. Ulsan: UUP;205–225.

3. Baddini-Caramelli C, Hatanaka M, Polati M, et al. Thickness of the retinal nerve fiber layer in amblyopic and normal eyes: a scannig laser polarimetry study. J AAPOS. 2001. 5:82–84.

4. Wiesel TN, Hubel DH. Effects of visual deprivation on morphology and physiology of cells in cat's lateral geniculate body. J Neurophysiol. 1963. 26:978–993.

5. Kang JH, Kim SA, Song WG, Yoon HS. Macular thickness change measured by OCT in increasing age of normal Korean. J Korean Ophthalmol Soc. 2004. 45:592–598.

6. Hee MR, Puliafito CA, Ducker JS, et al. Topography of diabetic macular with optical coherence tomography. Ophthalmology. 1998. 105:360–370.

7. Brancato R. Optical coherence tomography (OCT) in macular edema. Doc Ophthalmol. 1999. 97:337–339.

8. Hee MR, Izatt JA, Swanson EA, et al. Optical coherence tomography of human retina. Arch Ophthalmol. 1995. 113:325–332.

9. von Noorden GK, Dowling JE, Ferguson DC. Experimental amblyopia in monkeys. I. Behavioral studies of stimulus deprivation amblyopia. Arch Ophthalmol. 1970. 84:206–214.

10. The Korean strabismus and pediatric ophthalmological society. Current Concepts in Strabismus. 2004. 1st ed. Seoul: Naewae Haksool;117–129.

11. von Noorden GK, Grawford MLJ, Levacy RA. The lateral geniculate nucleus in human anisometric amblyopia. Invest Ophthalmol Vis Sci. 1983. 24:788–790.

12. Rasch E, Swift H, Reisen AH, Chow KL. Altered structure and composition of retinal cells in dark-reared mammals. Exp Cell Res. 1961. 25:348–363.

13. Chow KL, Reisen AH, Newell FN. Degeneration of retinal ganglion cells in infant chimpanzees reared in darkness. J Comp Neurol. 1957. 107:27–42.

14. Chow KL. Failure to demonstrate change in the visual system of monkey kept in darkness or colored light. J Comp Neurol. 1955. 102:597–606.

15. von Noorden GK, Crawford MLJ, Middleditch PR. Effect of lid suture on retinal ganglion cells in Macaca mulatta. Brain Res. 1977. 122:437–444.

16. Hogan MJ, Alvarado JA, Weddell JE. Histology of the Human Eye. 1971. Philadelphia: WB Saunders Company;492.

17. Kanai K, Abe T, Murayama K, Yoneya S. Retinal thickness and changes with age. Nippon Ganka Gakkai Zasshi. 2002. 106:162–165.

18. Ling Y, Liu X, Zehng X. Quantitative measurement of macular thickness in normal subjects by optical coherence tomography. Yan Ke Xue Bao. 2000. 16:87–90.

19. Gobel W, Kretzchmar-Gross T. Retinal thickness in diabetic retinopathy: a study using optical coherence tomography. Retina. 2002. 22:759–767.

20. Varma R, Bazzaz S, Lai M. Optical Tomography-measured retinal nerve fiber layer thickness in normal Latinos. Invest Ophthalmol Vis Sc. 2003. 44:3369–3373.

21. Schuman JS, Hee MR, Puliafito CA, et al. Quantification of nerve fiber layer thickness in normal thickness in normal and glacomatous eyes using optical coherence tomography. Arch Ophthalmol. 1995. 113:586–596.

22. Bowd C, Weinreb RN, Williams JM, Zangwill LM. The retinal nerver fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography. Arch Ophthalmol. 2000. 118:22–26.

23. Liu X, Ling Y, Luo R, et al. Optical coherence tomography measuring retinal nerve fiber layer thickness in normal subjects and patients with open-angle glaucoma. Chin Med J. 2001. 114:524–529.

24. Colen TP, de Faber JT, Lemij HG. Retinal nerve fiber layer thickness in human strabismic amblyopia. Binocul Vis Strabismus Q. 2005. 15:141–146.

25. Yen MY, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci. 2004. 45:2224–2230.