Korean J Ophthalmol.  2005 Sep;19(3):235-238. 10.3341/kjo.2005.19.3.235.

Subretinal Inflammatory Myofibroblastic Tumor: Clinicopathological Findings

• Oh JY
• Yu HG

• KMID: 754431
• DOI: http://doi.org/10.3341/kjo.2005.19.3.235

Abstract

PURPOSE
To present a case of inflammatory myofibroblastic tumor which was manifested as an idiopathic subretinal mass without underlying pathology. METHODS: The subretinal mass was surgically excised and evaluated histopathologically. Fluorescein angiography and optical coherence tomography were performed pre- and post-operatively. RESULTS: The mass was histologically composed of lymphoplasma cell infiltration and fibrous proliferation without microorganisms or malignant cells. Immunohistochemistry for smooth muscle actin revealed myofibroblasts as a major cellular component. Preoperative optical coherent tomography showed that the lesion was contiguous to the retina while inducing foveal detachment. Postoperatively, the fovea was attached with visual recovery, and the subretinal lesion did not recur during the follow up. CONCLUSIONS: Inflammatory myofibroblastic tumors may be included in the differential diagnoses of subretinal masses.

Keyword

Inflammatory myofibroblastic tumor; Optical coherence tomography; Subretinal mass

MeSH Terms

Tomography, Optical Coherence
Retina/pathology
Neoplasms, Muscle Tissue/diagnosis/*pathology
Male
Inflammation/pathology
Humans
Fundus Oculi
Fluorescence
Eye Neoplasms/*pathology
Choroid/pathology
Atrophy
Angiography
Adult

Figure

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  Fig. 1 Clinical findings pre- (A, C, E) and post-operatively (B, D, F). (A) Color fundus photograph shows a well-defined, white subretinal mass. (B) Chorioretinal atrophy developed in the excision site. (C) Fluorescence angiography shows tumor staining with a distinct border in the late frames. (D) Late phase of fluorescence angiogram shows choroidal atrophy at the excision site. (E) Optical coherence tomography shows that the lesion is contiguous to the retina (above), while inducing macular detachment (below). (F) Neurosensory retinal detachment disappeared in both the excision site (above) and macula (below).

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  Fig. 2 (A) Gross photograph of the subretinal lesion shows a 1×1 mm -sized, firm, round, and yellowish tumor. (B) Pathology shows both lymphoplasma cell infiltration and fibrous proliferation (hematoxylin and eosin, ×100). (C) Lymphoplasma cells were infiltrated, presenting chronic nongranulomatous inflammation (hematoxylin-eosin, ×400). (D) Immunohistochemistry for α-smooth muscle actin, a marker for smooth muscle differentiation (×200). The majority of cells in the fibrous proliferation are myofibroblasts, which are α-smooth muscle actin-positive (brown).

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