Yonsei Med J.  1999 Oct;40(5):413-419. 10.3349/ymj.1999.40.5.413.

Comparison of Gadomer-17 and Gd-DTPA in image quality of contrast-enhanced MR angiographies using flow phantom model

Affiliations
  • 1Department of Diagnostic Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. tschung@yumc.yonsei.ac.kr
  • 2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
  • 4Schering AG, Berlin, 5Siemens AG, Erlangen, Germany.

Abstract

The purpose of this study was to compare the image quality of 3D-TOF MR angiography (MRA) using Gadomer-17 with that using Gd-DTPA in a flow phantom model, and to present preliminary data about the proper dose concentration of Gadomer-17. In the visual analysis of vessel conspicuity, we compared the quality of pre- and post-contrast MIP images. For quantitative analysis, the signal intensities were measured in the axial base 3D-TOF images, and then the relative contrast enhancement was calculated. The results of our studies were that: 1. Maximal signal intensities were obtained at 1 mmol/L of Gadomer-17 and 4 mmol/L of Gd-DTPA. 2. Flow-related signal loss was decreased by Gd-DTPA proportional to the concentration, but Gadomer-17 did not show such a dose accumulative effect. In conclusion, after comparing the results of Gd-DTPA, it was clear that improved MRA images and higher signal intensities of vessels were obtained when lower concentrations of Gadomer-17 were used.

Keyword

Magnetic resonance imaging; carotid flow phantom; magnetic resonance angiography; Gadolinium
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