Yonsei Med J.  1978 Dec;19(2):35-47. 10.3349/ymj.1978.19.2.35.

A Study of Gastric Carcinoma among Koreans with Special Reference to the Pathogenetic relation of Intestinal Metaplasia

Affiliations
  • 1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

A total of 556 cases of stomachs resected for gastric carcinoma were classified according to Laur n's method (1965), and were studied for epidemiological evaluation, relation to chronic gastritis, especially that with intestinal metaplasia, and prognostic difference, with the following results: 1) When classified by Laur n's method, 52.2% (290/556) of gastric carcinomas among Koreans belonged to intestinal type, 40.6% (226/556) to diffuse and 7.2% (40/556) to the other type of carcinoma. 2) In males the incidence of diffuse carcinoma was less frequent than that of intestinal type carcinoma, but in the female it was as frequent as the latter. 3) The higher incidence of stomach carcinoma in the male among Koreans may be attributed to the frequent occurrence of not only intestinal type but also diffuse carcinoma. 4) The mean age of patients with intestinal type carcinoma was older than that of diffuse by approximately 7 years. 5) The lower mean age of gastric carcinoma among Koreans is attributable to the lower age distribution of intestinal type as well as of diffuse carcinoma. 6) The occurrence of large tumor size, short symptom duration, ulcero-infiltrative gowth, regional node metastasis and regional nodes showing lymphocyte depletion and unstimulated were more frequent in diffuse carcinoma, indirectly supporting the view that patients with intestinal type carcinoma are more likely to survive for longer periods than patients with diffuse carcinoma. 7) Intestinal metaplasia of the nearby stomach mucosa showed a significantly higher percentage in intestinal type than diffuse carcinoma, further supporting the suggestion that intestinal type carcinoma is pathogenetically related to intestinal metaplasia of stomach mucosa.


MeSH Terms

Adolescent
Adult
Aged
Carcinoma/epidemiology*
Carcinoma/pathology
Child
Female
Gastric Mucosa/pathology*
Human
Korea
Male
Metaplasia
Middle Age
Stomach Neoplasms/epidemiology*
Stomach Neoplasms/pathology
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