Allergy Asthma Respir Dis.
2026 Apr;14(2):97-100. 10.4168/aard.2026.14.2.97.
Successful desensitization to contrast media in a patient with recurrent hypersensitivity to multiple iodinated contrast agents: A case report
- Affiliations
-
- 1Department of Internal Medicine, Division of Allergy and Clinical Immunology, Seoul National University College of Medicine, Seoul
- 2Drug Safety Monitoring Center, Seoul National University Hospital, Seoul
- 3Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam
- 4Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
- KMID: 2580549
- DOI: http://doi.org/10.4168/aard.2026.14.2.97
Abstract
- Hypersensitivity reactions (HSRs) to iodinated contrast media (ICM) can range from mild cutaneous symptoms to life-threatening anaphylaxis. In patients with a history of ICM hypersensitivity, avoidance of the culprit agent is generally recommended. This case report describes a successful desensitization in a 56-year-old man with recurrent HSRs to multiple agents including ioversol, iohexol, iobitridol, and iopamidol. Intradermal testing was performed to identify potentially safe alternatives; however, all tested agents, including iohexol, ioversol, iobitridol, iopamidol, iodixanol, iomeprol, and iopromide, yielded positive results. Given the clinical necessity of transcatheter arterial chemoembolization, a 13-step rapid desensitization protocol with iodixanol was implemented. The procedure was completed without any breakthrough reactions. This case highlights desensitization as a feasible and effective strategy for patients with hypersensitivity to multiple ICM agents.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Recent Updates on Diagnosis and Prevention of Hypersensitivity Reactions to Iodinated Contrast Media
- Change of culprit agent prevents recurrent hypersensitivity reactions to iodinated contrast media
- Endoscopic Retrograde Cholangiopancreatography Using Barium Sulfate As a Contrast Material
- Management of hypersensitivity reactions to contrast media
- A Case Report on a Severe Anaphylaxis Reaction to Gadolinium-Based MR Contrast Media
