J Bone Metab.  2026 Feb;33(1):84-93. 10.11005/jbm.26.1014.

Cross-Calibration of Bone Mineral Density and Body Composition between GE Lunar Prodigy and Hologic Horizon W Dual Energy X-Ray Absorptiometry Systems

• Kim S
• Lee GY
• Yoo JI
• Lee SW
• Ha YC

• KMID: 2578644
• DOI: http://doi.org/10.11005/jbm.26.1014

Abstract

Background
Dual energy X-ray absorptiometry (DXA) measurements vary among instruments from different manufacturers. This study aimed to assess the correlation between bone mineral density (BMD) and body composition measured by the GE Lunar Prodigy and Hologic Horizon W DXA systems and to develop conversion equations.
Methods
A total of 120 healthy volunteers (59 males, 61 females) aged 20 to 70 years were scanned on both DXA systems on the same day. BMD was measured at the lumbar spine (L1-L4) and bilateral femurs. Body composition parameters were measured for the whole body and regional sites. Bland-Altman analysis, Pearson correlation, and concordance correlation coefficient (CCC) were used to assess agreement. Linear regression was performed to derive conversion equations.
Results
The Hologic system measured BMD values 14% to 20% lower at the lumbar spine and 8% to 17% lower at femoral sites compared to the GE Lunar system (all P<0.0001). Lean mass values were 4% to 10% lower on the Hologic system. Very strong correlations were observed for both BMD (r=0.944-0.980) and lean mass (r=0.963-0.984). Cross-calibration equations were developed for all measurement sites.
Conclusions
Despite significant systematic differences, there was very high correlation between the two DXA systems. The conversion equations can facilitate comparison of measurements between these systems in clinical practice and research.

Keyword

Absorptiometry; photon · Body composition · Bone density · Calibration