Anat Biol Anthropol.  2025 Sep;38(3):159-164. 10.11637/aba.2025.38.3.159.

Inspecting Post-stroke Mechanisms and Treatment for Stroke Recovery

• Kim Y
• Chung YY
• Hwang HI
• Shin HK
• Jun YH

• KMID: 2574925
• DOI: http://doi.org/10.11637/aba.2025.38.3.159

Abstract

Followed by not only neurological detriment including motor disorders, but also decline in the quality of life, stroke is a well-known major factor of death, worldwide. Plenty of methods to enhance patient recovery and several post-stroke remedies are being explored until now. In this review, post-stroke inflammatory processes, including BBB breakdown and its effect, will be handled along with the work of microglia activation. Necroptosis, a type of cell death as a result of proinflammatory reaction, will also be addressed to specify its mechanism throughout the post-stroke procedure. This review displays those factors in the spotlight these days to deduce progressive poststroke therapeutic approaches, as well as the other participants of the post-stroke inflammatory process such as the work of T cells. Meanwhile, there are some other approaches under investigation related to making out post-stroke recovery advancement. This review handles the utilization of iPSCs (induced pluripotent stem cells) as a promising access toward innovative post-stroke treatment. Furthermore, this review concludes by pointing out some targets that are under research to develop efficacious post-stroke treatment and highlights the directions where the future investigation for effective post-stroke therapeutic approaches have to head for.

Keyword

Stroke; BBB; Microglia; Inflammation; Necroptosis