Parasit Host Dis.
2025 Nov;63(4):360-363. 10.3347/PHD.25053.
Glucose-6-phosphate dehydrogenase variants in Kachin, Myanmar
- Affiliations
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- 1Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea
- 2Vector Borne Diseases Control Unit, Kachin State Public Health Department, Myitkyina 10111, Myanmar
- 3Institute for Veterinary Biomedical Science, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
- KMID: 2574496
- DOI: http://doi.org/10.3347/PHD.25053
Abstract
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive genetic disorder that can cause severe anemia in affected individuals exposed to oxidative stress. This risk is particularly relevant in patients treated with the antimalarial drug primaquine. In Myanmar, primaquine has been widely administered as a Plasmodium vivax malaria treatment; however, prevalence of G6PD deficiency among the population remains insufficiently characterized. This study investigated the prevalence of G6PD variants among various minority ethnic subgroups residing in Kachin State, Myanmar. Blood samples from 440 participants were analyzed; however, the Mahidol variant (G487A) was identified in 21 individuals (4.8%). A major limitation of this study was the absence of G6PD enzyme activity data to confirm whether the Mahidol variant induces G6PD deficiency.
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