Korean J Vet Res.  2025 Jun;65(2):e11. 10.14405/kjvr.20240067.

Multiple autoimmune syndrome in a dog presented with hematologic disease: a rare case report

• Park J
• Shin C
• Kang M
• Cha S
• Lee SL
• Jung DI
• Yu D
• Bae H

• KMID: 2572891
• DOI: http://doi.org/10.14405/kjvr.20240067

Abstract

Multiple autoimmune syndrome (MAS) refers to the occurrence of three or more autoimmune diseases in a patient. This case describes a 12-year-old neutered male Shih Tzu with fever and neutropenia, previously diagnosed with immune-mediated thrombocytopenia, immune-mediated hemolytic anemia, and inflammatory bowel disease. Blood tests revealed leukopenia and neutropenia, and immune-mediated neutropenia was suspected after ruling out other causes of neutropenia. The dog showed no response to antibiotics, but treatment with prednisolone (2 mg/kg q24h) led to improvement. This case highlights the potential for MASs to occur in dogs and underscores the importance of their recognition in the diagnosis and management of immune-mediated diseases.

Keyword

Polyendocrinopathies, Autoimmune; dogs; hematologic disease; case reports