Kidney Res Clin Pract.  2025 Jul;44(4):553-565. 10.23876/j.krcp.25.130.

Steroid-sensitive nephrotic syndrome in children: Korean Society of Pediatric Nephrology clinical practice recommendations

• Lee HK
• Cho MH
• Cho MH
• Lee YH
• Kim JY
• Lee JH
• Kang HG
• Park E
• Suh JS
• Park DA
• Cho H
• on behalf of the Childhood Nephrotic Syndrome Guideline Development Group

• KMID: 2572851
• DOI: http://doi.org/10.23876/j.krcp.25.130

Abstract

Pediatric nephrotic syndrome is a clinical condition characterized by severe proteinuria, hypoalbuminemia, hyperlipidemia, and generalized edema, most commonly affecting children aged 2 and 6 years. Although standard oral steroid therapy is effective in managing most cases, relapses are common during childhood. Nephrotic syndrome presents significant challenges due to frequent relapses and the potential side effects of long-term drug therapy. In Korea, the absence of a unified national clinical guideline has led physicians to manage pediatric nephrotic syndrome based on diverse clinical guidelines and individual clinical judgment. To address this, the Korean Society of Pediatric Nephrology has developed an evidence-based guideline specifically tailored to the Korean healthcare system. This guideline provides recommendations for the diagnosis and management of steroid-sensitive nephrotic syndrome in children under the age of 18 years.

Keyword

Child; Evidence-based practice; GRADE approach; Practice guideline; Nephrotic syndrome