Infect Chemother.
2025 Sep;57(3):418-423. 10.3947/ic.2025.0032.
Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant Pseudomonas aeruginosa Isolates from a Multicenter Study in Korea
- Affiliations
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- 1Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- 2Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 3Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan College of Medicine, Seoul, Korea
- 4Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea
- 5Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
- 6Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
- 7Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea
- 8Department of Laboratory Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
- 9Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- KMID: 2572609
- DOI: http://doi.org/10.3947/ic.2025.0032
Abstract
- Owing to concern that carbapenemase-producing strains among carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates is on the rise, we investigated the genetic epidemiology and antimicrobial susceptibilities of clinical CRPA isolates collected in four academic hospitals in Korea. Carbapenemase genes were detected in 46 of 63 CRPA isolates (73.0%) collected between 2021 and 2024, and blaNDM< ST773 was the most common genotype (27 isolates, 42.9%), followed by blasub>NDM ST644 (9 isolates, 14.3%) and blaIMP ST235 (7 isolates, 11.1%). Overall susceptibility to ceftazidime/avibactam was only 17.5%, and none of the carbapenemase-producing isolates were susceptible to it. All ST644 strains were also resistant to aztreonam.
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