Acute Crit Care.  2025 May;40(2):153-159. 10.4266/acc.000900.

Clinical applications of blood gas analysis: a comparative review of arterial and venous blood gas monitoring in critical care

• Lee GR

• KMID: 2569425
• DOI: http://doi.org/10.4266/acc.000900

Abstract

Blood gas analysis is an essential diagnostic tool used for assessing acid-base balance, ventilation, and oxygenation in critically ill patients. Arterial blood gas analysis (ABGA) remains the gold standard, primarily due to its accuracy in measuring oxygenation. Venous blood gas analysis (VBGA), in contrast, serves as a less invasive alternative and is particularly useful for evaluating acid-base status and metabolic function. Important parameters such as oxygen saturation of central venous blood (ScvO₂) and venous-to-arterial carbon dioxide pressure difference (∆pv-aCO₂) provide critical insights into hemodynamic status, cardiac output, and tissue perfusion. Although VBGA cannot replace ABGA for the precise assessment of oxygenation, it remains a valuable tool in clinical scenarios involving hemodynamic monitoring, shock management, and critical care decision-making.

Keyword

arterial blood gas analysis; blood gas analysis; central venous oxygen saturation; venous blood gas analysis; venous-to-arterial carbon dioxide pressure difference