Ann Dermatol.
2024 Jun;36(3):135-144. 10.5021/ad.23.156.
Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging
- Affiliations
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- 1Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA
- 2Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea
- KMID: 2568504
- DOI: http://doi.org/10.5021/ad.23.156
Abstract
- Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key downstream effectors of the Hippo signaling pathway, which plays a central role in tissue homeostasis, organ development, and regeneration. While the dysregulation of YAP/TAZ has been linked to various human diseases, their involvement in the aging of human skin has only recently begun to manifest. In the skin, the YAP/TAZ effectors emerge as central regulators in maintaining homeostasis of epidermal stem cells and dermal extracellular matrix, and thus intimately linked to skin aging processes. This review underscores recent molecular breakthroughs highlighting how age-related decline of YAP/TAZ activity impacts human epidermal and dermal aging. Gaining insight into the evolving roles of YAP/TAZ in human skin aging presents a promising avenue for the development of innovative therapeutic approaches aimed at enhancing skin health and addressing age-related skin conditions.
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