Diabetes Metab J.
2023 May;47(3):315-324. 10.4093/dmj.2022.0333.
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
- Affiliations
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- 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
- 2Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA
- KMID: 2542508
- DOI: http://doi.org/10.4093/dmj.2022.0333
Abstract
- Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.
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