Clin Psychopharmacol Neurosci.  2023 Feb;21(1):126-134. 10.9758/cpn.2023.21.1.126.

Effects of Long-acting Injectable 3-Monthly Paliperidone Palmitate on the Clinical and Social Performance of Patients with Schizophrenia

  • 1Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 2Maumpyeonhan Mental Health Clinic, Bucheon, Korea.
  • 3Department of Psychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • 4Yangsan Hospital, Yangsan, Korea.
  • 5Department of Psychiatry, Ewha Womans University College of Medicine, Seoul, Korea.
  • 6Institute of Spirituality and Mental Health, St. Andrew's Hospital, Icheon, Korea.
  • 7Department of Psychiatry, Maryknoll Medical Center, Busan, Korea.
  • 8Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
  • 9Department of Psychiatry, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul, Korea.
  • 10Medical Affairs, Janssen Korea, Seoul, Korea.


To investigate the effects of long-acting injectable 3-monthly paliperidone palmitate on the clinical and social functioning of patients with schizophrenia.
This study enrolled patients with schizophrenia receiving long-acting injectable 1-monthly paliperidone palmitate for at least 4 months and who subsequently received 3-monthly paliperidone palmitate. Accordingly, 418 patients were followed up for 24 weeks. Their clinical symptoms and social functioning were measured using the Clinical Global Impression-Severity of Illness and Personal and Social Performance scales.
The Personal and Social Performance total score was significantly higher after 3-monthly paliperidone palmitate treatment than at baseline (baseline vs. week 24: 54.3 ± 18.0 vs. 61.0 ± 14.5 [mean ± standard deviation]; p < 0.001; Wilcoxon signed-rank test); the proportion of patients in the mildly ill group (scores 71−100) also increased significantly (baseline vs. week 24: 16.5% vs. 20.6%; p< 0.001; McNemar-Bowker test). The mean Clinical Global Impression-Severity of Illness score decreased significantly (baseline vs. week 24: 3.7 ± 1.0 vs. 3.4 ± 0.9; p< 0.001; Wilcoxon signed-rank test), as did the proportion of patients in the severely ill group (baseline vs. week 24: 4.1% vs. 2.1%; p < 0.001; McNemar-Bowker test).
Continuous 3-monthly paliperidone palmitate treatment significantly enhances the personal and social performance of patients with schizophrenia and reduces the proportion of those with severe illness. These findings suggest that long-acting injectable antipsychotic administration at intervals longer than 1 month might improve the social functioning of and promote return to activities of daily living in patients with schizophrenia.


Schizophrenia; Antipsychotics; Paliperidone palmitate; Clinical global impression; Personal and social performance.
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